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Murcko scaffold

Ring system with 3 rings and 19 atoms

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
17
With full pages
10
Scaffold SMILES

O=C(Nc1nccs1)c1cc2ccccc2[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nccs1)c1cc2ccccc2[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

4-Hydroxy-1-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide chemical structure, C15H13N3O3S, CAS 280112-18-7
4-Hydroxy-1-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide
CAS 280112-18-7C15H13N3O3S
4-Hydroxy-1-(3-methylbutyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H21N3O3S, CAS 280112-26-7
4-Hydroxy-1-(3-methylbutyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 280112-26-7C19H21N3O3S
4-Hydroxy-1-(3-methylbutyl)-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H21N3O3S, CAS 280112-15-4
4-Hydroxy-1-(3-methylbutyl)-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 280112-15-4C19H21N3O3S
1-Butyl-4-hydroxy-N-{5-nitro-1,3-thiazol-2-yl}-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C17H16N4O5S, CAS 330817-48-6
1-Butyl-4-hydroxy-N-{5-nitro-1,3-thiazol-2-yl}-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 330817-48-6C17H16N4O5S
1-Hexyl-4-hydroxy-N-(5-nitrothiazol-2-yl)-2-oxo-quinoline-3-carboxamide chemical structure, C19H20N4O5S, CAS 330817-49-7
1-Hexyl-4-hydroxy-N-(5-nitrothiazol-2-yl)-2-oxo-quinoline-3-carboxamide
CAS 330817-49-7C19H20N4O5S
2,4-Dihydroxy-N-(1,3-thiazol-2-yl)quinoline-3-carboxamide chemical structure, C13H9N3O3S, CAS 167565-14-2
2,4-Dihydroxy-N-(1,3-thiazol-2-yl)quinoline-3-carboxamide
CAS 167565-14-2C13H9N3O3S
4-Hydroxy-1-methyl-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C15H13N3O3S, CAS 84088-59-5
4-Hydroxy-1-methyl-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 84088-59-5C15H13N3O3S
4-Hydroxy-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1-(prop-2-en-1-yl)-1,2-dihydroquinoline-3-carboxamide chemical structure, C17H15N3O3S, CAS 280112-10-9
4-Hydroxy-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1-(prop-2-en-1-yl)-1,2-dihydroquinoline-3-carboxamide
CAS 280112-10-9C17H15N3O3S
4-Hydroxy-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1-pentyl-1,2-dihydroquinoline-3-carboxamide chemical structure, C19H21N3O3S, CAS 280112-14-3
4-Hydroxy-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1-pentyl-1,2-dihydroquinoline-3-carboxamide
CAS 280112-14-3C19H21N3O3S
Ethyl (2-{[(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}-1,3-thiazol-4-yl)acetate chemical structure, C18H17N3O5S, CAS 334498-20-3
Ethyl (2-{[(4-hydroxy-1-methyl-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}-1,3-thiazol-4-yl)acetate
CAS 334498-20-3C18H17N3O5S
4-Hydroxy-1-isobutyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide chemical structure, C18H19N3O3S, CAS 280112-24-5
4-Hydroxy-1-isobutyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide
CAS 280112-24-5C18H19N3O3S
4-Hydroxy-2-oxo-1-pentyl-N-thiazol-2-yl-quinoline-3-carboxamide chemical structure, C18H19N3O3S, CAS 167565-17-5
4-Hydroxy-2-oxo-1-pentyl-N-thiazol-2-yl-quinoline-3-carboxamide
CAS 167565-17-5C18H19N3O3S
1,2-Dihydro-4-hydroxy-1-methyl-2-oxo-N-2-thiazolyl-3-quinolinecarboxamide chemical structure, C14H11N3O3S, CAS 84088-57-3
1,2-Dihydro-4-hydroxy-1-methyl-2-oxo-N-2-thiazolyl-3-quinolinecarboxamide
CAS 84088-57-3C14H11N3O3S
1-Ethyl-4-hydroxy-2-oxo-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide chemical structure, C15H13N3O3S, CAS 167565-15-3
1-Ethyl-4-hydroxy-2-oxo-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide
CAS 167565-15-3C15H13N3O3S
4-Hydroxy-2-oxo-1-(prop-2-en-1-yl)-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide chemical structure, C16H13N3O3S, CAS 313986-01-5
4-Hydroxy-2-oxo-1-(prop-2-en-1-yl)-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide
CAS 313986-01-5C16H13N3O3S
4-Hydroxy-1-(2-methylpropyl)-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H19N3O3S, CAS 280112-13-2
4-Hydroxy-1-(2-methylpropyl)-N-(4-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 280112-13-2C18H19N3O3S
1-Butyl-4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide chemical structure, C18H19N3O3S, CAS 280112-23-4
1-Butyl-4-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS 280112-23-4C18H19N3O3S