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Murcko scaffold

Ring system with 4 rings and 23 atoms

411 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 411
With full pages: 64

Scaffold SMILES

O=c1c(=Cc2ccccc2)sc2n1C(c1ccccc1)C=CN=2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(=Cc2ccccc2)sc2n1C(c1ccccc1)C=CN=2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 411 chemicals

(R,E)-2-(4-((5-(4-Chlorophenyl)-6-(isopropoxycarbonyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl)phenoxy)aceticacid chemical structure, C26H23ClN2O6S, CAS 1257238-57-5

(R,E)-2-(4-((5-(4-Chlorophenyl)-6-(isopropoxycarbonyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl)phenoxy)aceticacid

CAS 1257238-57-5C₂₆H₂₃ClN₂O₆S

(S)-2-(4-((5-(4-Chlorophenyl)-6-(isopropoxycarbonyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl)phenoxy)aceticacid chemical structure, C26H23ClN2O6S, CAS 1257238-58-6

(S)-2-(4-((5-(4-Chlorophenyl)-6-(isopropoxycarbonyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl)phenoxy)aceticacid

CAS 1257238-58-6C₂₆H₂₃ClN₂O₆S

Ethyl 2-{[2-(acetyloxy)-5-bromophenyl]methylidene}-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H21BrN2O5S, CAS 5522-72-5

Ethyl 2-{[2-(acetyloxy)-5-bromophenyl]methylidene}-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5522-72-5C₂₅H₂₁BrN₂O₅S

Ethyl 2-[(4-acetylphenyl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22N2O4S, CAS 5533-11-9

Ethyl 2-[(4-acetylphenyl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5533-11-9C₂₅H₂₂N₂O₄S

Ethyl 2-[(2-chlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H19ClN2O3S, CAS 292871-30-8

Ethyl 2-[(2-chlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 292871-30-8C₂₃H₁₉ClN₂O₃S

Ethyl 2,3-dihydro-5-(4-methoxyphenyl)-7-methyl-2-[(3-nitrophenyl)methylene]-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H21N3O6S, CAS 300723-23-3

Ethyl 2,3-dihydro-5-(4-methoxyphenyl)-7-methyl-2-[(3-nitrophenyl)methylene]-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 300723-23-3C₂₄H₂₁N₃O₆S

Ethyl 2-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-5-(3,4-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H27N3O9S, CAS 5673-99-4

Ethyl 2-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-5-(3,4-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5673-99-4C₂₇H₂₇N₃O₉S

Ethyl 2-[(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H25BrN2O5S, CAS 5675-16-1

Ethyl 2-[(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5675-16-1C₂₇H₂₅BrN₂O₅S

Ethyl (2E)-2-(3,4-dichlorobenzylidene)-7-methyl-5-(4-methylphenyl)-3-oxo-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate chemical structure, C24H20Cl2N2O3S, CAS 419551-32-9

Ethyl (2E)-2-(3,4-dichlorobenzylidene)-7-methyl-5-(4-methylphenyl)-3-oxo-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate

CAS 419551-32-9C₂₄H₂₀Cl₂N₂O₃S

Ethyl 2-[(3,5-dichloro-2-hydroxyphenyl)methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22Cl2N2O6S, CAS 5816-03-5

Ethyl 2-[(3,5-dichloro-2-hydroxyphenyl)methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5816-03-5C₂₅H₂₂Cl₂N₂O₆S

Ethyl 2-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H23BrN2O6S, CAS 5832-47-3

Ethyl 2-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5832-47-3C₂₅H₂₃BrN₂O₆S

2-[4-[[5-(4-Chlorophenyl)-7-methyl-3-oxo-6-[oxo(propan-2-yloxy)methyl]-5H-thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid chemical structure, C26H23ClN2O6S

2-[4-[[5-(4-Chlorophenyl)-7-methyl-3-oxo-6-[oxo(propan-2-yloxy)methyl]-5H-thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid

C₂₆H₂₃ClN₂O₆S

Ethyl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H28Cl2N2O4S, CAS 618092-77-6

Ethyl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618092-77-6C₂₈H₂₈Cl₂N₂O₄S

2-Methylpropyl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H32Cl2N2O4S, CAS 618092-81-2

2-Methylpropyl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618092-81-2C₃₀H₃₂Cl₂N₂O₄S

2-Propen-1-yl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H28Cl2N2O4S, CAS 618092-85-6

2-Propen-1-yl 2-[(3,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-[4-(pentyloxy)phenyl]-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618092-85-6C₂₉H₂₈Cl₂N₂O₄S

1-Methylethyl 2-[(3,4-dimethoxyphenyl)methylene]-2,3-dihydro-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H28N2O6S, CAS 380155-14-6

1-Methylethyl 2-[(3,4-dimethoxyphenyl)methylene]-2,3-dihydro-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 380155-14-6C₂₇H₂₈N₂O₆S

Ethyl 5-(3-ethoxy-4-methoxyphenyl)-2-[(4-fluorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H25FN2O5S, CAS 371923-99-8

Ethyl 5-(3-ethoxy-4-methoxyphenyl)-2-[(4-fluorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 371923-99-8C₂₆H₂₅FN₂O₅S

2-[4-[[6-Ethoxycarbonyl-7-methyl-5-[4-(methylthio)phenyl]-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid chemical structure, C26H24N2O6S2, CAS 445426-44-8

2-[4-[[6-Ethoxycarbonyl-7-methyl-5-[4-(methylthio)phenyl]-3-oxo-5H-thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid

CAS 445426-44-8C₂₆H₂₄N₂O₆S₂

2-Methylpropyl 2-[(2,4-dichlorophenyl)methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H26Cl2N2O4S, CAS 618090-97-4

2-Methylpropyl 2-[(2,4-dichlorophenyl)methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618090-97-4C₂₇H₂₆Cl₂N₂O₄S

2-Propen-1-yl 2-[(2,4-dichlorophenyl)methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H22Cl2N2O4S, CAS 618091-01-3

2-Propen-1-yl 2-[(2,4-dichlorophenyl)methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618091-01-3C₂₆H₂₂Cl₂N₂O₄S

Ethyl 2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-(4-propoxyphenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H24Cl2N2O4S, CAS 618091-08-0

Ethyl 2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-(4-propoxyphenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618091-08-0C₂₆H₂₄Cl₂N₂O₄S

1-Methylethyl 2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-(4-propoxyphenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H26Cl2N2O4S, CAS 618091-11-5

1-Methylethyl 2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5-(4-propoxyphenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618091-11-5C₂₇H₂₆Cl₂N₂O₄S

1-Methylethyl 5-(4-butoxyphenyl)-2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H28Cl2N2O4S, CAS 618091-24-0

1-Methylethyl 5-(4-butoxyphenyl)-2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618091-24-0C₂₈H₂₈Cl₂N₂O₄S

2-Methoxyethyl 5-(4-butoxyphenyl)-2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H28Cl2N2O5S, CAS 618091-28-4

2-Methoxyethyl 5-(4-butoxyphenyl)-2-[(2,4-dichlorophenyl)methylene]-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 618091-28-4C₂₈H₂₈Cl₂N₂O₅S