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Murcko scaffold

Ring system with 3 rings and 20 atoms

5 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
5
With full pages
2
Scaffold SMILES

O=S(=O)(Nc1ccccc1Nc1ccccc1)C1CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(Nc1ccccc1Nc1ccccc1)C1CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

N-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide chemical structure, C19H20F3IN2O5S, CAS 923032-36-4
N-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
CAS 923032-36-4C19H20F3IN2O5S
Refametinib chemical structure, C19H20F3IN2O5S, CAS 923032-37-5
Refametinib
CAS 923032-37-5C19H20F3IN2O5S
Refametinib (R enantiomer) chemical structure, C19H20F3IN2O5S, CAS 923032-38-6
Refametinib (R enantiomer)
CAS 923032-38-6C19H20F3IN2O5S
1-(2-Hydroxyethyl)-N-[3,4,6-trifluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]cyclopropanesulfonamide chemical structure, C17H15F4IN2O3S, CAS 923032-39-7
1-(2-Hydroxyethyl)-N-[3,4,6-trifluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]cyclopropanesulfonamide
CAS 923032-39-7C17H15F4IN2O3S
1-Allyl-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)cyclopropane-1-sulfonamide chemical structure, C18H16F3IN2O2S, CAS 923032-61-5
1-Allyl-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)cyclopropane-1-sulfonamide
CAS 923032-61-5C18H16F3IN2O2S