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Murcko scaffold

1-Phenethylpiperazine scaffold

457 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
457
With full pages
17
Scaffold SMILES

c1ccc(CCN2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenethylpiperazine page
Murcko scaffold c1ccc(CCN2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 457 chemicals

1-Phenethylpiperazine chemical structure, C12H18N2, CAS 5321-49-3
1-Phenethylpiperazine
CAS 5321-49-3C12H18N2
1-(2-Methoxy-2-phenylethyl)piperazine chemical structure, C13H20N2O, CAS 6722-54-9
1-(2-Methoxy-2-phenylethyl)piperazine
CAS 6722-54-9C13H20N2O
1-Piperazineacetic acid, alpha-benzyl-4-methyl-, methyl ester chemical structure, C15H22N2O2, CAS 7012-68-2
1-Piperazineacetic acid, alpha-benzyl-4-methyl-, methyl ester
CAS 7012-68-2C15H22N2O2
1-Piperazineethanol, beta-benzyl-4-methyl- chemical structure, C14H22N2O, CAS 7032-45-3
1-Piperazineethanol, beta-benzyl-4-methyl-
CAS 7032-45-3C14H22N2O
1-Butyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2) chemical structure, C17H30Cl2N2, CAS 16018-25-0
1-Butyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2)
CAS 16018-25-0C17H30Cl2N2
1-Piperazineethanol, 4-(alpha-methylphenethyl)-, dihydrochloride chemical structure, C15H26Cl2N2O, CAS 16018-26-1
1-Piperazineethanol, 4-(alpha-methylphenethyl)-, dihydrochloride
CAS 16018-26-1C15H26Cl2N2O
1-Octyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2) chemical structure, C21H38Cl2N2, CAS 16018-29-4
1-Octyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2)
CAS 16018-29-4C21H38Cl2N2
Piperazine, 1-phenethyl-4-propionyl-, hydrochloride chemical structure, C15H23ClN2O, CAS 18907-67-0
Piperazine, 1-phenethyl-4-propionyl-, hydrochloride
CAS 18907-67-0C15H23ClN2O
Piperazine, 1-(beta-(sec-butyl)-5-chloro-2-ethoxyphenethyl)-4-methyl- chemical structure, C19H31ClN2O, CAS 29122-64-3
Piperazine, 1-(beta-(sec-butyl)-5-chloro-2-ethoxyphenethyl)-4-methyl-
CAS 29122-64-3C19H31ClN2O
Piperazine, 1-butyryl-4-(o-chlorophenethyl)-, hydrochloride chemical structure, C16H24Cl2N2O, CAS 22929-31-3
Piperazine, 1-butyryl-4-(o-chlorophenethyl)-, hydrochloride
CAS 22929-31-3C16H24Cl2N2O
2-(4-Methyl-piperazin-1-yl)-1-phenyl-ethanol chemical structure, C13H20N2O, CAS 5408-15-1
2-(4-Methyl-piperazin-1-yl)-1-phenyl-ethanol
CAS 5408-15-1C13H20N2O
2-(3-Methyl-4-phenethylpiperazin-1-yl)ethanol chemical structure, C15H24N2O, CAS 5464-96-0
2-(3-Methyl-4-phenethylpiperazin-1-yl)ethanol
CAS 5464-96-0C15H24N2O
4-[3-Methyl-4-(2-phenylethyl)piperazin-1-yl]butan-1-ol chemical structure, C17H28N2O, CAS 5464-97-1
4-[3-Methyl-4-(2-phenylethyl)piperazin-1-yl]butan-1-ol
CAS 5464-97-1C17H28N2O
3-[3-Methyl-4-(2-phenylethyl)piperazin-1-yl]propan-1-ol chemical structure, C16H26N2O, CAS 5472-76-4
3-[3-Methyl-4-(2-phenylethyl)piperazin-1-yl]propan-1-ol
CAS 5472-76-4C16H26N2O
1-(2-(3,4-Dichlorophenyl)ethyl)-4-methylpiperazine chemical structure, C13H18Cl2N2, CAS 150208-28-9
1-(2-(3,4-Dichlorophenyl)ethyl)-4-methylpiperazine
CAS 150208-28-9C13H18Cl2N2
1-[2-(3,4-Dichlorophenyl)ethyl]-4-propylpiperazine chemical structure, C15H22Cl2N2, CAS 150208-29-0
1-[2-(3,4-Dichlorophenyl)ethyl]-4-propylpiperazine
CAS 150208-29-0C15H22Cl2N2
1-[4-(2-Phenylethyl)piperazin-1-yl]ethanone chemical structure, C14H20N2O, CAS 415923-82-9
1-[4-(2-Phenylethyl)piperazin-1-yl]ethanone
CAS 415923-82-9C14H20N2O
Ethyl 4-(2-phenylethyl)-1-piperazinecarboxylate chemical structure, C15H22N2O2, CAS 33169-60-7
Ethyl 4-(2-phenylethyl)-1-piperazinecarboxylate
CAS 33169-60-7C15H22N2O2
2-[4-(2-Phenylethyl)piperazin-1-yl]ethan-1-ol chemical structure, C14H22N2O, CAS 58103-25-6
2-[4-(2-Phenylethyl)piperazin-1-yl]ethan-1-ol
CAS 58103-25-6C14H22N2O
3-Oxo-3-[4-(2-phenylethyl)piperazin-1-yl]propanenitrile chemical structure, C15H19N3O, CAS 717858-21-4
3-Oxo-3-[4-(2-phenylethyl)piperazin-1-yl]propanenitrile
CAS 717858-21-4C15H19N3O
Methyl 4-(2-phenylethyl)piperazine-1-carboxylate chemical structure, C14H20N2O2, CAS 717867-45-3
Methyl 4-(2-phenylethyl)piperazine-1-carboxylate
CAS 717867-45-3C14H20N2O2
N,N-Dimethyl-4-[2-(trifluoromethyl)phenethyl]tetrahydro-1(2H)-pyrazinesulfonamide chemical structure, C15H22F3N3O2S, CAS 400086-13-7
N,N-Dimethyl-4-[2-(trifluoromethyl)phenethyl]tetrahydro-1(2H)-pyrazinesulfonamide
CAS 400086-13-7C15H22F3N3O2S
4-(2-Phenylethyl)-N-propylpiperazine-1-carbothioamide chemical structure, C16H25N3S, CAS 774550-03-7
4-(2-Phenylethyl)-N-propylpiperazine-1-carbothioamide
CAS 774550-03-7C16H25N3S
tert-Butyl 4-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperazine-1-carboxylate chemical structure, C18H28N2O4, CAS 904815-65-2
tert-Butyl 4-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperazine-1-carboxylate
CAS 904815-65-2C18H28N2O4