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Murcko scaffold

Ring system with 4 rings and 22 atoms

81 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 81
With full pages: 2

Scaffold SMILES

O=c1ccc2ccc3c(c2o1)CN(Cc1ccccc1)CO3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1ccc2ccc3c(c2o1)CN(Cc1ccccc1)CO3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 81 chemicals

9-(4-Methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C20H19NO4, CAS 887691-83-0

9-(4-Methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 887691-83-0C₂₀H₁₉NO₄

3,4-Dimethyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C21H21NO3, CAS 858758-74-4

3,4-Dimethyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858758-74-4C₂₁H₂₁NO₃

9-(4-Methylbenzyl)-4-propyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C22H23NO3, CAS 858761-98-5

9-(4-Methylbenzyl)-4-propyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858761-98-5C₂₂H₂₃NO₃

4-Methyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C20H19NO3, CAS 858767-52-9

4-Methyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858767-52-9C₂₀H₁₉NO₃

9-(4-Methoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C19H17NO4, CAS 858767-63-2

9-(4-Methoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858767-63-2C₁₉H₁₇NO₄

4-Ethyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C21H21NO3, CAS 859138-86-6

4-Ethyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859138-86-6C₂₁H₂₁NO₃

9-(4-Fluorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C18H14FNO3, CAS 848918-87-6

9-(4-Fluorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 848918-87-6C₁₈H₁₄FNO₃

3-Ethyl-4-methyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C22H23NO3, CAS 844461-93-4

3-Ethyl-4-methyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 844461-93-4C₂₂H₂₃NO₃

4-Ethyl-9-(4-fluorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C20H18FNO3, CAS 845660-59-5

4-Ethyl-9-(4-fluorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 845660-59-5C₂₀H₁₈FNO₃

9-(2-Chlorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C18H14ClNO3, CAS 845983-31-5

9-(2-Chlorobenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 845983-31-5C₁₈H₁₄ClNO₃

9-(4-Fluorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C19H16FNO3, CAS 846580-87-8

9-(4-Fluorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 846580-87-8C₁₉H₁₆FNO₃

9-(2-Chlorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C19H16ClNO3, CAS 846594-08-9

9-(2-Chlorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 846594-08-9C₁₉H₁₆ClNO₃

4-Butyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C23H25NO3, CAS 858760-39-1

4-Butyl-9-(4-methylbenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858760-39-1C₂₃H₂₅NO₃

4-Propyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C24H27NO6, CAS 858764-82-6

4-Propyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858764-82-6C₂₄H₂₇NO₆

3-Ethyl-9-(4-methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C22H23NO4, CAS 858767-51-8

3-Ethyl-9-(4-methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858767-51-8C₂₂H₂₃NO₄

4-Methyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C22H23NO6, CAS 858770-38-4

4-Methyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 858770-38-4C₂₂H₂₃NO₆

4-Butyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C25H29NO6, CAS 859137-63-6

4-Butyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859137-63-6C₂₅H₂₉NO₆

4-Ethyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C23H25NO6, CAS 859139-09-6

4-Ethyl-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859139-09-6C₂₃H₂₅NO₆

4-Ethyl-9-(4-methoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C21H21NO4, CAS 859139-26-7

4-Ethyl-9-(4-methoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859139-26-7C₂₁H₂₁NO₄

4-Butyl-6-chloro-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C25H28ClNO6, CAS 859139-35-8

4-Butyl-6-chloro-9-(3,4,5-trimethoxybenzyl)-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859139-35-8C₂₅H₂₈ClNO₆

9-[(2-Chloro-6-fluorophenyl)methyl]-3,4-dimethyl-8,10-dihydropyrano[2,3-f][1,3]benzoxazin-2-one chemical structure, C20H17ClFNO3, CAS 859860-66-5

9-[(2-Chloro-6-fluorophenyl)methyl]-3,4-dimethyl-8,10-dihydropyrano[2,3-f][1,3]benzoxazin-2-one

CAS 859860-66-5C₂₀H₁₇ClFNO₃

9-(2-Methoxybenzyl)-3,4-dimethyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C21H21NO4, CAS 859107-92-9

9-(2-Methoxybenzyl)-3,4-dimethyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859107-92-9C₂₁H₂₁NO₄

9-(2-Methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C20H19NO4, CAS 859109-55-0

9-(2-Methoxybenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859109-55-0C₂₀H₁₉NO₄

9-(4-Chlorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one chemical structure, C19H16ClNO3, CAS 859129-04-7

9-(4-Chlorobenzyl)-4-methyl-9,10-dihydro-2H,8H-chromeno[8,7-e][1,3]oxazin-2-one

CAS 859129-04-7C₁₉H₁₆ClNO₃