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Murcko scaffold

Ring system with 3 rings and 26 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
14
With full pages
3
Scaffold SMILES

O=C(Nc1ccccc1)Nc1cccc(NC(=O)Nc2ccccc2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1cccc(NC(=O)Nc2ccccc2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

1-(4-Fluorophenyl)-3-[3-[(4-fluorophenyl)carbamoylamino]phenyl]urea chemical structure, C20H16F2N4O2, CAS 383389-79-5
1-(4-Fluorophenyl)-3-[3-[(4-fluorophenyl)carbamoylamino]phenyl]urea
CAS 383389-79-5C20H16F2N4O2
1,1'-(1,3-Phenylene)bis(3-(3-(trifluoromethyl)phenyl)urea) chemical structure, C22H16F6N4O2, CAS 304509-90-8
1,1'-(1,3-Phenylene)bis(3-(3-(trifluoromethyl)phenyl)urea)
CAS 304509-90-8C22H16F6N4O2
N,N''-(4-Methyl-1,3-phenylene)bis[N'-(4-methylphenyl)urea] chemical structure, C23H24N4O2, CAS 54390-87-3
N,N''-(4-Methyl-1,3-phenylene)bis[N'-(4-methylphenyl)urea]
CAS 54390-87-3C23H24N4O2
1-(3-Fluorophenyl)-3-[3-[(3-fluorophenyl)carbamoylamino]phenyl]urea chemical structure, C20H16F2N4O2, CAS 405151-28-2
1-(3-Fluorophenyl)-3-[3-[(3-fluorophenyl)carbamoylamino]phenyl]urea
CAS 405151-28-2C20H16F2N4O2
1,1'-(5-(Trifluoromethyl)-1,3-phenylene)bis(3-phenylurea) chemical structure, C21H17F3N4O2, CAS 329765-22-2
1,1'-(5-(Trifluoromethyl)-1,3-phenylene)bis(3-phenylurea)
CAS 329765-22-2C21H17F3N4O2
1-(5-((((4-Chlorophenyl)amino)carbonyl)amino)-o-tolyl)-3-(p-tolyl)urea chemical structure, C22H21ClN4O2, CAS 94158-50-6
1-(5-((((4-Chlorophenyl)amino)carbonyl)amino)-o-tolyl)-3-(p-tolyl)urea
CAS 94158-50-6C22H21ClN4O2
1,1'-(1,3-Phenylene)bis(3-(3-chlorophenyl)urea) chemical structure, C20H16Cl2N4O2, CAS 392708-66-6
1,1'-(1,3-Phenylene)bis(3-(3-chlorophenyl)urea)
CAS 392708-66-6C20H16Cl2N4O2
N,N''-(2-Methyl-1,3-phenylene)bis[N'-phenylurea] chemical structure, C21H20N4O2, CAS 149358-54-3
N,N''-(2-Methyl-1,3-phenylene)bis[N'-phenylurea]
CAS 149358-54-3C21H20N4O2
1-(4-Fluorophenyl)-3-[3-[(4-fluorophenyl)carbamoylamino]-4-nitrophenyl]urea chemical structure, C20H15F2N5O4, CAS 6525-70-8
1-(4-Fluorophenyl)-3-[3-[(4-fluorophenyl)carbamoylamino]-4-nitrophenyl]urea
CAS 6525-70-8C20H15F2N5O4
1-[2-Methyl-5-(phenylcarbamoylamino)phenyl]-3-phenylurea chemical structure, C21H20N4O2, CAS 60903-54-0
1-[2-Methyl-5-(phenylcarbamoylamino)phenyl]-3-phenylurea
CAS 60903-54-0C21H20N4O2
1,1'-(2-Methylbenzene-1,3-diyl)bis[3-(4-methylphenyl)urea] chemical structure, C23H24N4O2, CAS 1187573-14-3
1,1'-(2-Methylbenzene-1,3-diyl)bis[3-(4-methylphenyl)urea]
CAS 1187573-14-3C23H24N4O2
Urea,1'-m-phenylenebis[3-[p-(N,N'-dimethylamidino)phenyl]-, dihydrochloride chemical structure, C26H31ClN8O2, CAS 5262-16-8
Urea,1'-m-phenylenebis[3-[p-(N,N'-dimethylamidino)phenyl]-, dihydrochloride
CAS 5262-16-8C26H31ClN8O2
4,4'-[(4-Methyl-1,3-phenylene)bis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1) chemical structure, C27H33ClN8O2, CAS 25775-76-2
4,4'-[(4-Methyl-1,3-phenylene)bis(carbamoylazanediyl)]bis(N,N'-dimethylbenzene-1-carboximidamide)--hydrogen chloride (1/1)
CAS 25775-76-2C27H33ClN8O2
3,5-Bis-[3-(3-bromo-phenyl)-ureido]-benzoic acid chemical structure, C21H16Br2N4O4, CAS 674300-88-0
3,5-Bis-[3-(3-bromo-phenyl)-ureido]-benzoic acid
CAS 674300-88-0C21H16Br2N4O4