Murcko scaffold
Ring system with 4 rings and 28 atoms
24 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 24
- With full pages
- 1
Scaffold SMILES
O=C(CSc1cn(CC(=O)N2CCCC2)c2ccccc12)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 24 of 24 chemicals
N-(2,3-Dimethylphenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-69-0C24H27N3O2S
N-(2,5-Dimethylphenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-70-3C24H27N3O2S
N-(4-Ethylphenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-74-7C24H27N3O2S
N-(3-Chloro-4-methylphenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-82-7C23H24ClN3O2S
![N-(5-Chloro-2-methoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C23H24ClN3O3S, CAS 877658-83-8](/s/XAOMVGLTNHTXRW-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-83-8C23H24ClN3O3S
![N-(2-Methoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C23H25N3O3S, CAS 877658-84-9](/s/WGHAQDFJBYYZFG-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-84-9C23H25N3O3S
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-97-4C23H21ClF3N3O2S
![Ethyl 4-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate chemical structure, C25H27N3O4S, CAS 877659-00-2](/s/FSRRAFCZIOWRPN-UHFFFAOYSA-N.svg)
Ethyl 4-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate
CAS 877659-00-2C25H27N3O4S
![N-(3-Acetamidophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H26N4O3S, CAS 877659-03-5](/s/AFUQJSIGVQUKBM-UHFFFAOYSA-N.svg)
N-(3-Acetamidophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877659-03-5C24H26N4O3S
2-((1-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(m-tolyl)acetamide
CAS 877658-67-8C23H25N3O2S
2-((1-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(p-tolyl)acetamide
CAS 877658-68-9C23H25N3O2S
![N-(2,4-Dimethylphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O2S, CAS 877658-71-4](/s/ZLAKJMNYHHKHGY-UHFFFAOYSA-N.svg)
N-(2,4-Dimethylphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-71-4C24H27N3O2S
![N-(3,5-Dimethylphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O2S, CAS 877658-72-5](/s/KHIURPJWQOEYHV-UHFFFAOYSA-N.svg)
N-(3,5-Dimethylphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-72-5C24H27N3O2S
N-(2-Fluorophenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-76-9C22H22FN3O2S
![N-(3-Fluorophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C22H22FN3O2S, CAS 877658-77-0](/s/CUWMAGRFSWOVMM-UHFFFAOYSA-N.svg)
N-(3-Fluorophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-77-0C22H22FN3O2S
![N-(4-Fluorophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C22H22FN3O2S, CAS 877658-78-1](/s/BBLMWMUJJMJFOC-UHFFFAOYSA-N.svg)
N-(4-Fluorophenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-78-1C22H22FN3O2S
![N-(2-Ethoxyphenyl)-2-{[1-(2-oxo-2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide chemical structure, C24H27N3O3S, CAS 877658-87-2](/s/OKTVSMBITVUBEN-UHFFFAOYSA-N.svg)
N-(2-Ethoxyphenyl)-2-{[1-(2-oxo-2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]thio}acetamide
CAS 877658-87-2C24H27N3O3S
N-(2,4-Dimethoxyphenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877658-89-4C24H27N3O4S
![N-(2,5-Dimethoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide chemical structure, C24H27N3O4S, CAS 877658-90-7](/s/ZGGMGLXUIQNVJW-UHFFFAOYSA-N.svg)
N-(2,5-Dimethoxyphenyl)-2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamide
CAS 877658-90-7C24H27N3O4S
2-((1-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide
CAS 877658-96-3C23H22F3N3O2S
![Ethyl 2-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate chemical structure, C25H27N3O4S, CAS 877658-99-6](/s/OODPDXDOFLIKCO-UHFFFAOYSA-N.svg)
Ethyl 2-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate
CAS 877658-99-6C25H27N3O4S
![Methyl 4-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate chemical structure, C24H25N3O4S, CAS 877659-01-3](/s/PJYOKLBDRTVFIM-UHFFFAOYSA-N.svg)
Methyl 4-[2-({1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1H-indol-3-yl}sulfanyl)acetamido]benzoate
CAS 877659-01-3C24H25N3O4S
N-(4-Acetamidophenyl)-2-((1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)acetamide
CAS 877659-04-6C24H26N4O3S
2-((1-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide
CAS 877658-98-5C23H22F3N3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
