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Murcko scaffold

Ring system with 2 rings and 16 atoms

44 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
44
With full pages
14
Scaffold SMILES

O=c1ccnc(N=CNc2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccnc(N=CNc2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

1-(2,4-Dimethylphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine chemical structure, C14H17N5O
1-(2,4-Dimethylphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine
C14H17N5O
Guanidine, 1-(p-chlorophenyl)-3-(4-hydroxy-6-methyl-2-pyrimidinyl)- chemical structure, C12H12ClN5O, CAS 5429-13-0
Guanidine, 1-(p-chlorophenyl)-3-(4-hydroxy-6-methyl-2-pyrimidinyl)-
CAS 5429-13-0C12H12ClN5O
N-(3-Chloro-2-methylphenyl)-N'-(4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)guanidine chemical structure, C14H16ClN5O, CAS 488796-42-5
N-(3-Chloro-2-methylphenyl)-N'-(4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)guanidine
CAS 488796-42-5C14H16ClN5O
2-({[(4-Ethoxyphenyl)amino]iminomethyl}amino)-6-methylpyrimidin-4-ol chemical structure, C14H17N5O2
2-({[(4-Ethoxyphenyl)amino]iminomethyl}amino)-6-methylpyrimidin-4-ol
C14H17N5O2
Ethyl {2-[N'-(3,4-dimethylphenyl)carbamimidamido]-6-hydroxypyrimidin-4-yl}acetate chemical structure, C17H21N5O3, CAS 448915-01-3
Ethyl {2-[N'-(3,4-dimethylphenyl)carbamimidamido]-6-hydroxypyrimidin-4-yl}acetate
CAS 448915-01-3C17H21N5O3
1-(4-Methoxyphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine chemical structure, C13H15N5O2
1-(4-Methoxyphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine
C13H15N5O2
N-(1,6-Dihydro-4-methyl-6-oxo-2-pyrimidinyl)-N'-(4-methylphenyl)guanidine chemical structure, C13H15N5O, CAS 15233-35-9
N-(1,6-Dihydro-4-methyl-6-oxo-2-pyrimidinyl)-N'-(4-methylphenyl)guanidine
CAS 15233-35-9C13H15N5O
N-(1,6-Dihydro-4-methyl-6-oxo-2-pyrimidinyl)-N'-(3-nitrophenyl)guanidine chemical structure, C12H12N6O3, CAS 131699-74-6
N-(1,6-Dihydro-4-methyl-6-oxo-2-pyrimidinyl)-N'-(3-nitrophenyl)guanidine
CAS 131699-74-6C12H12N6O3
N-(3,5-Bis(trifluoromethyl)phenyl)-N'-(4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl)guanidine chemical structure, C14H8F9N5O, CAS 618092-26-5
N-(3,5-Bis(trifluoromethyl)phenyl)-N'-(4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl)guanidine
CAS 618092-26-5C14H8F9N5O
N-(2,3-Dichlorophenyl)-N'-[4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl]guanidine chemical structure, C12H8Cl2F3N5O
N-(2,3-Dichlorophenyl)-N'-[4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl]guanidine
C12H8Cl2F3N5O
N-(2,3-Dimethylphenyl)-N'-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine chemical structure, C14H17N5O, CAS 777867-00-2
N-(2,3-Dimethylphenyl)-N'-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine
CAS 777867-00-2C14H17N5O
1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)guanidine chemical structure, C14H8F9N5O
1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)guanidine
C14H8F9N5O
Methyl 2-[2-[[amino-(4-propan-2-ylanilino)methylidene]amino]-4-oxo-1H-pyrimidin-6-yl]acetate chemical structure, C17H21N5O3
Methyl 2-[2-[[amino-(4-propan-2-ylanilino)methylidene]amino]-4-oxo-1H-pyrimidin-6-yl]acetate
C17H21N5O3
Methyl(2-{[imino(4-isopropylanilino)methyl]amino}-6-oxo-3,6-dihydro-4-pyrimidinyl)acetate chemical structure, C17H21N5O3, CAS 667431-01-8
Methyl(2-{[imino(4-isopropylanilino)methyl]amino}-6-oxo-3,6-dihydro-4-pyrimidinyl)acetate
CAS 667431-01-8C17H21N5O3
1-(3-Chlorophenyl)-3-(4-hydroxy-6-(methoxymethyl)pyrimidin-2-yl)guanidine chemical structure, C13H14ClN5O2, CAS 433973-61-6
1-(3-Chlorophenyl)-3-(4-hydroxy-6-(methoxymethyl)pyrimidin-2-yl)guanidine
CAS 433973-61-6C13H14ClN5O2
N-(2,3-Dichlorophenyl)-N'-(4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl)guanidine chemical structure, C12H8Cl2F3N5O, CAS 618092-24-3
N-(2,3-Dichlorophenyl)-N'-(4-hydroxy-6-(trifluoromethyl)-2-pyrimidinyl)guanidine
CAS 618092-24-3C12H8Cl2F3N5O
Ethyl {2-[N'-(2,4-dimethylphenyl)carbamimidamido]-6-hydroxypyrimidin-4-yl}acetate chemical structure, C17H21N5O3, CAS 433687-69-5
Ethyl {2-[N'-(2,4-dimethylphenyl)carbamimidamido]-6-hydroxypyrimidin-4-yl}acetate
CAS 433687-69-5C17H21N5O3
1-(3-Chloro-2-methylphenyl)-3-(4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)guanidine chemical structure, C14H16ClN5O
1-(3-Chloro-2-methylphenyl)-3-(4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)guanidine
C14H16ClN5O
1-(4-Ethoxyphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine chemical structure, C14H17N5O2
1-(4-Ethoxyphenyl)-3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine
C14H17N5O2
1-[4-Bromo-alpha,alpha,alpha-trifluoro-m-tolyl]-3-[4-hydroxy-6-methyl-2pyrimidinyl]guanidine chemical structure, C13H11BrF3N5O, CAS 51388-14-8
1-[4-Bromo-alpha,alpha,alpha-trifluoro-m-tolyl]-3-[4-hydroxy-6-methyl-2pyrimidinyl]guanidine
CAS 51388-14-8C13H11BrF3N5O
Guanidine, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(1,4-dihydro-6-methyl-4-oxo-2-pyrimidinyl)- chemical structure, C13H11ClF3N5O, CAS 51388-13-7
Guanidine, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(1,4-dihydro-6-methyl-4-oxo-2-pyrimidinyl)-
CAS 51388-13-7C13H11ClF3N5O
N-(2,4-Dimethylphenyl)-N'-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine chemical structure, C14H17N5O, CAS 370871-14-0
N-(2,4-Dimethylphenyl)-N'-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)guanidine
CAS 370871-14-0C14H17N5O
1-(4-Fluorophenyl)-3-(4-hydroxy-6-methylpyrimidin-2-yl)guanidine chemical structure, C12H12FN5O, CAS 330-37-0
1-(4-Fluorophenyl)-3-(4-hydroxy-6-methylpyrimidin-2-yl)guanidine
CAS 330-37-0C12H12FN5O
1-(3-Chlorophenyl)-3-(4-hydroxy-5,6-dimethylpyrimidin-2-yl)guanidine chemical structure, C13H14ClN5O, CAS 488094-27-5
1-(3-Chlorophenyl)-3-(4-hydroxy-5,6-dimethylpyrimidin-2-yl)guanidine
CAS 488094-27-5C13H14ClN5O