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Murcko scaffold

Ring system with 4 rings and 22 atoms

44 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
44
With full pages
6
Scaffold SMILES

O=c1c(=Cc2ccco2)sc2n1C(c1ccccc1)C=CN=2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(=Cc2ccco2)sc2n1C(c1ccccc1)C=CN=2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

2-Propen-1-yl 2,3-dihydro-7-methyl-2-[(5-methyl-2-furanyl)methylene]-3-oxo-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H20N2O4S, CAS 381680-41-7
2-Propen-1-yl 2,3-dihydro-7-methyl-2-[(5-methyl-2-furanyl)methylene]-3-oxo-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 381680-41-7C23H20N2O4S
Methyl (2Z)-2-(2-furylmethylene)-5-(4-(methoxycarbonyl)phenyl)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate chemical structure, C22H18N2O6S, CAS 609795-00-8
Methyl (2Z)-2-(2-furylmethylene)-5-(4-(methoxycarbonyl)phenyl)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate
CAS 609795-00-8C22H18N2O6S
Prop-2-en-1-yl 2-[(furan-2-yl)methylidene]-7-methyl-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H20N2O4S2, CAS 6997-65-5
Prop-2-en-1-yl 2-[(furan-2-yl)methylidene]-7-methyl-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 6997-65-5C23H20N2O4S2
Ethyl (2Z)-2-(furan-2-ylmethylidene)-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H20N2O4S, CAS 324072-22-2
Ethyl (2Z)-2-(furan-2-ylmethylidene)-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324072-22-2C22H20N2O4S
Methyl (2E)-2-(furan-2-ylmethylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C21H18N2O5S, CAS 5849-69-4
Methyl (2E)-2-(furan-2-ylmethylidene)-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 5849-69-4C21H18N2O5S
Ethyl 5-(2-chlorophenyl)-7-methyl-2-[(5-methyl-2-furyl)methylene]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H19ClN2O4S, CAS 331979-75-0
Ethyl 5-(2-chlorophenyl)-7-methyl-2-[(5-methyl-2-furyl)methylene]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 331979-75-0C22H19ClN2O4S
(Z)-Ethyl 2-((5-bromofuran-2-yl)methylene)-7-methyl-3-oxo-5-(p-tolyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H19BrN2O4S, CAS 351222-85-0
(Z)-Ethyl 2-((5-bromofuran-2-yl)methylene)-7-methyl-3-oxo-5-(p-tolyl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 351222-85-0C22H19BrN2O4S
Ethyl (2E)-2-[(5-iodofuran-2-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H19IN2O5S, CAS 5822-09-3
Ethyl (2E)-2-[(5-iodofuran-2-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 5822-09-3C22H19IN2O5S
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2,4-dimethoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H21BrN2O6S, CAS 292871-77-3
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2,4-dimethoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 292871-77-3C23H21BrN2O6S
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H21BrN2O6S, CAS 292641-92-0
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 292641-92-0C23H21BrN2O6S
Ethyl (2Z)-2-(furan-2-ylmethylidene)-5-(2-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H20N2O5S, CAS 305866-30-2
Ethyl (2Z)-2-(furan-2-ylmethylidene)-5-(2-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 305866-30-2C22H20N2O5S
Ethyl 2-{[5-(dimethylamino)-2-furyl]methylene}-5-(4-ethoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H27N3O5S, CAS 354561-10-7
Ethyl 2-{[5-(dimethylamino)-2-furyl]methylene}-5-(4-ethoxyphenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 354561-10-7C25H27N3O5S
Ethyl (2Z)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H22N2O4S2, CAS 306309-60-4
Ethyl (2Z)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 306309-60-4C23H22N2O4S2
Ethyl 2-{[5-(dimethylamino)-2-furyl]methylene}-5-(4-fluorophenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H22FN3O4S, CAS 340294-36-2
Ethyl 2-{[5-(dimethylamino)-2-furyl]methylene}-5-(4-fluorophenyl)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 340294-36-2C23H22FN3O4S
Propan-2-yl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H21BrN2O5S, CAS 6195-19-3
Propan-2-yl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 6195-19-3C23H21BrN2O5S
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2-chlorophenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C21H16BrClN2O4S, CAS 331979-78-3
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(2-chlorophenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 331979-78-3C21H16BrClN2O4S
(Z)-Ethyl 7-methyl-2-((5-methylfuran-2-yl)methylene)-3-oxo-5-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C22H20N2O4S, CAS 327055-32-3
(Z)-Ethyl 7-methyl-2-((5-methylfuran-2-yl)methylene)-3-oxo-5-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 327055-32-3C22H20N2O4S
Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H24N2O6S, CAS 328264-91-1
Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 328264-91-1C24H24N2O6S
Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H22N2O5S, CAS 878384-65-7
Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-[(5-methylfuran-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 878384-65-7C23H22N2O5S
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(3,4-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C23H21BrN2O6S, CAS 292641-37-3
Ethyl (2Z)-2-[(5-bromofuran-2-yl)methylidene]-5-(3,4-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 292641-37-3C23H21BrN2O6S
Ethyl 2-(2-furylmethylene)-5-{3-nitrophenyl}-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C21H17N3O6S, CAS 324073-94-1
Ethyl 2-(2-furylmethylene)-5-{3-nitrophenyl}-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324073-94-1C21H17N3O6S
Ethyl (2Z)-7-methyl-2-[(5-nitrofuran-2-yl)methylidene]-3-oxo-5-(4-prop-2-enoxyphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H21N3O7S, CAS 428501-94-4
Ethyl (2Z)-7-methyl-2-[(5-nitrofuran-2-yl)methylidene]-3-oxo-5-(4-prop-2-enoxyphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 428501-94-4C24H21N3O7S
Ethyl (2E)-2-[[5-(diethylamino)furan-2-yl]methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H27N3O4S, CAS 428834-12-2
Ethyl (2E)-2-[[5-(diethylamino)furan-2-yl]methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 428834-12-2C25H27N3O4S
Prop-2-en-1-yl (2Z)-5-[4-(acetyloxy)phenyl]-2-(furan-2-ylmethylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H20N2O6S, CAS 383370-14-7
Prop-2-en-1-yl (2Z)-5-[4-(acetyloxy)phenyl]-2-(furan-2-ylmethylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 383370-14-7C24H20N2O6S