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Murcko scaffold

Ring system with 4 rings and 23 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 18
With full pages: 1

Scaffold SMILES

O=C1NC2=C(C(=O)N(Cc3ccco3)C2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC2=C(C(=O)N(Cc3ccco3)C2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

6-(Furan-2-ylmethyl)-1-methyl-4-phenyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O3, CAS 695224-05-6

6-(Furan-2-ylmethyl)-1-methyl-4-phenyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 695224-05-6C₁₈H₁₇N₃O₃

6-(Furan-2-ylmethyl)-4-(4-hydroxyphenyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O4, CAS 696640-14-9

6-(Furan-2-ylmethyl)-4-(4-hydroxyphenyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 696640-14-9C₁₈H₁₇N₃O₄

6-(Furan-2-ylmethyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H16N4O5, CAS 895845-38-2

6-(Furan-2-ylmethyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 895845-38-2C₁₈H₁₆N₄O₅

6-[(Furan-2-yl)methyl]-4-(4-methylphenyl)-1H,2H,3H,4H,5H,6H,7H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O3, CAS 874594-22-6

6-[(Furan-2-yl)methyl]-4-(4-methylphenyl)-1H,2H,3H,4H,5H,6H,7H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 874594-22-6C₁₈H₁₇N₃O₃

6-(Furan-2-ylmethyl)-4-(4-methoxyphenyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H19N3O4, CAS 853617-46-6

6-(Furan-2-ylmethyl)-4-(4-methoxyphenyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 853617-46-6C₁₉H₁₉N₃O₄

4-(3-Fluorophenyl)-6-[(furan-2-yl)methyl]-1H,2H,3H,4H,5H,6H,7H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C17H14FN3O3, CAS 946270-44-6

4-(3-Fluorophenyl)-6-[(furan-2-yl)methyl]-1H,2H,3H,4H,5H,6H,7H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946270-44-6C₁₇H₁₄FN₃O₃

6-(Furan-2-ylmethyl)-4-(3,4,5-trimethoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C20H21N3O6, CAS 899736-47-1

6-(Furan-2-ylmethyl)-4-(3,4,5-trimethoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 899736-47-1C₂₀H₂₁N₃O₆

4-(4-Fluorophenyl)-6-(furan-2-ylmethyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H16FN3O3, CAS 1043615-56-0

4-(4-Fluorophenyl)-6-(furan-2-ylmethyl)-1-methyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 1043615-56-0C₁₈H₁₆FN₃O₃

4-(4-Chlorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C17H14ClN3O3, CAS 946218-56-0

4-(4-Chlorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946218-56-0C₁₇H₁₄ClN₃O₃

6-(Furan-2-ylmethyl)-4-(m-tolyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O3, CAS 946373-05-3

6-(Furan-2-ylmethyl)-4-(m-tolyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946373-05-3C₁₈H₁₇N₃O₃

6-(Furan-2-ylmethyl)-4-(4-methoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O4, CAS 946373-09-7

6-(Furan-2-ylmethyl)-4-(4-methoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946373-09-7C₁₈H₁₇N₃O₄

4-(4-Ethoxyphenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H19N3O4, CAS 946270-68-4

4-(4-Ethoxyphenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946270-68-4C₁₉H₁₉N₃O₄

4-(2-Fluorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C17H14FN3O3, CAS 1021122-32-6

4-(2-Fluorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 1021122-32-6C₁₇H₁₄FN₃O₃

Methyl 4-(6-(furan-2-ylmethyl)-2,5-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-d]pyrimidin-4-yl)benzoate chemical structure, C19H17N3O5, CAS 946270-84-4

Methyl 4-(6-(furan-2-ylmethyl)-2,5-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-d]pyrimidin-4-yl)benzoate

CAS 946270-84-4C₁₉H₁₇N₃O₅

4-(3,4-Dichlorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C17H13Cl2N3O3, CAS 946325-57-1

4-(3,4-Dichlorophenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946325-57-1C₁₇H₁₃Cl₂N₃O₃

6-(Furan-2-ylmethyl)-4-(4-propoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C20H21N3O4, CAS 946270-92-4

6-(Furan-2-ylmethyl)-4-(4-propoxyphenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946270-92-4C₂₀H₂₁N₃O₄

6-(Furan-2-ylmethyl)-4-(4-(methylthio)phenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C18H17N3O3S, CAS 946219-13-2

6-(Furan-2-ylmethyl)-4-(4-(methylthio)phenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 946219-13-2C₁₈H₁₇N₃O₃S

4-(4-(Dimethylamino)phenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H20N4O3, CAS 1173042-85-7

4-(4-(Dimethylamino)phenyl)-6-(furan-2-ylmethyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione

CAS 1173042-85-7C₁₉H₂₀N₄O₃