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Murcko scaffold

Ring system with 4 rings and 27 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
20
With full pages
5
Scaffold SMILES

O=C(C1=CC(=O)N(CCCn2ccnc2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCCn2ccnc2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-methoxyphenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C22H21N3O4S, CAS 378760-63-5
1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-methoxyphenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378760-63-5C22H21N3O4S
1-(3-(1H-Imidazol-1-yl)propyl)-5-(4-fluorophenyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H18FN3O3S, CAS 380584-37-2
1-(3-(1H-Imidazol-1-yl)propyl)-5-(4-fluorophenyl)-3-hydroxy-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380584-37-2C21H18FN3O3S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-phenyl-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H19N3O3S, CAS 378210-45-8
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-phenyl-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378210-45-8C21H19N3O3S
2-(3-Bromophenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C21H18BrN3O3S, CAS 378772-33-9
2-(3-Bromophenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 378772-33-9C21H18BrN3O3S
2-(2,4-Dimethoxyphenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C23H23N3O5S, CAS 378208-14-1
2-(2,4-Dimethoxyphenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 378208-14-1C23H23N3O5S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H21N3O3S, CAS 380571-34-6
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380571-34-6C22H21N3O3S
2-(4-Chlorophenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C21H18ClN3O3S, CAS 380555-61-3
2-(4-Chlorophenyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 380555-61-3C21H18ClN3O3S
1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H18N4O5S, CAS 380887-92-3
1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(3-nitrophenyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380887-92-3C21H18N4O5S
5-(2,3-Dimethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C23H23N3O5S, CAS 371131-82-7
5-(2,3-Dimethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 371131-82-7C23H23N3O5S
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H25N3O6S, CAS 385419-76-1
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
CAS 385419-76-1C24H25N3O6S
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]pyrrolidine-2,3-dione chemical structure, C23H23N3O4S, CAS 370870-47-6
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]pyrrolidine-2,3-dione
CAS 370870-47-6C23H23N3O4S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yl)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H25N3O3S, CAS 384349-21-7
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yl)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 384349-21-7C24H25N3O3S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[3-(prop-2-en-1-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H23N3O4S, CAS 620152-07-0
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[3-(prop-2-en-1-yloxy)phenyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 620152-07-0C24H23N3O4S
3-Hydroxy-1-(3-imidazolylpropyl)-5-(3-methoxy-4-propoxyphenyl)-4-(2-thienylcar bonyl)-3-pyrrolin-2-one chemical structure, C25H27N3O5S, CAS 636991-42-9
3-Hydroxy-1-(3-imidazolylpropyl)-5-(3-methoxy-4-propoxyphenyl)-4-(2-thienylcar bonyl)-3-pyrrolin-2-one
CAS 636991-42-9C25H27N3O5S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-propoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H25N3O4S, CAS 615270-65-0
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-propoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 615270-65-0C24H25N3O4S
5-(3-Ethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H23N3O4S, CAS 619271-53-3
5-(3-Ethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 619271-53-3C23H23N3O4S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H25N3O4S, CAS 847159-34-6
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-4-(thiophene-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 847159-34-6C24H25N3O4S
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-propoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H25N3O4S, CAS 620151-36-2
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-propoxyphenyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 620151-36-2C24H25N3O4S
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C23H23N3O5S, CAS 503432-95-9
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 503432-95-9C23H23N3O5S
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one chemical structure, C25H27N3O5S, CAS 579441-97-7
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(3-imidazolylpropyl)-4-(2-thienylcarbonyl)-3-pyrrolin-2-one
CAS 579441-97-7C25H27N3O5S