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Murcko scaffold

Ring system with 4 rings and 27 atoms

19 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
19
With full pages
12
Scaffold SMILES

O=C(C1=CC(=O)N(CCCn2ccnc2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(CCCn2ccnc2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C25H27N3O5, CAS 845808-35-7
1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 845808-35-7C25H27N3O5
4-(2-Furoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H18N4O6, CAS 378212-42-1
4-(2-Furoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-nitrophenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 378212-42-1C21H18N4O6
5-(4-Chlorophenyl)-4-(2-furoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H18ClN3O4, CAS 378764-13-7
5-(4-Chlorophenyl)-4-(2-furoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 378764-13-7C21H18ClN3O4
5-(2,4-Dimethoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-1,5-dihydro-pyrrol-2-one chemical structure, C23H23N3O6, CAS 380902-28-3
5-(2,4-Dimethoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-1,5-dihydro-pyrrol-2-one
CAS 380902-28-3C23H23N3O6
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-imidazolylpropyl)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one chemical structure, C24H25N3O7, CAS 371116-95-9
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-imidazolylpropyl)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one
CAS 371116-95-9C24H25N3O7
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]pyrrolidine-2,3-dione chemical structure, C23H23N3O5, CAS 371922-19-9
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-[3-(1H-imidazol-1-yl)propyl]pyrrolidine-2,3-dione
CAS 371922-19-9C23H23N3O5
1-(3-(1H-Imidazol-1-yl)propyl)-5-(2,3-dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C23H23N3O6, CAS 384797-86-8
1-(3-(1H-Imidazol-1-yl)propyl)-5-(2,3-dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 384797-86-8C23H23N3O6
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H27N3O7, CAS 385392-19-8
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 385392-19-8C25H27N3O7
5-(2,5-Dimethoxyphenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(3-imidazolylpropyl)-3-pyrrolin-2-one chemical structure, C23H23N3O6, CAS 538339-72-9
5-(2,5-Dimethoxyphenyl)-4-(2-furylcarbonyl)-3-hydroxy-1-(3-imidazolylpropyl)-3-pyrrolin-2-one
CAS 538339-72-9C23H23N3O6
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25N3O5, CAS 620117-16-0
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 620117-16-0C25H25N3O5
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methyl-2-furoyl)-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H27N3O5, CAS 638134-11-9
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methyl-2-furoyl)-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 638134-11-9C25H27N3O5
5-(3-Ethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H23N3O5, CAS 619274-57-6
5-(3-Ethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 619274-57-6C23H23N3O5
5-(3-Ethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H25N3O5, CAS 620117-87-5
5-(3-Ethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 620117-87-5C24H25N3O5
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H25N3O5, CAS 619272-49-0
4-(Furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 619272-49-0C24H25N3O5
1-(3-(1H-Imidazol-1-yl)propyl)-5-(3-(allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C24H23N3O5, CAS 619273-24-4
1-(3-(1H-Imidazol-1-yl)propyl)-5-(3-(allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 619273-24-4C24H23N3O5
5-(4-Ethoxy-3-methoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H25N3O6, CAS 847044-66-0
5-(4-Ethoxy-3-methoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 847044-66-0C24H25N3O6
4-(Furan-2-ylcarbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H21N3O5, CAS 439947-25-8
4-(Furan-2-ylcarbonyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 439947-25-8C22H21N3O5
3-(Furan-2-carbonyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-2-(4-methylphenyl)-2H-pyrrol-5-one chemical structure, C22H21N3O4, CAS 439947-24-7
3-(Furan-2-carbonyl)-4-hydroxy-1-(3-imidazol-1-ylpropyl)-2-(4-methylphenyl)-2H-pyrrol-5-one
CAS 439947-24-7C22H21N3O4
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-methoxyphenyl)-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H23N3O5, CAS 879910-44-8
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-methoxyphenyl)-4-(5-methylfuran-2-carbonyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 879910-44-8C23H23N3O5