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Murcko scaffold

Quinone methide scaffold

40 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
40
With full pages
3
Scaffold SMILES

C=C1C=CC(=O)C=C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Quinone methide page
Murcko scaffold C=C1C=CC(=O)C=C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

2,5-Cyclohexadien-1-one, 2,6-bis(1,1-dimethylethyl)-4-ethylidene- chemical structure, C16H24O, CAS 6738-27-8
2,5-Cyclohexadien-1-one, 2,6-bis(1,1-dimethylethyl)-4-ethylidene-
CAS 6738-27-8C16H24O
2,6-Di-tert-butyl-4-methylene-2,5-cyclohexadienone chemical structure, C15H22O, CAS 2607-52-5
2,6-Di-tert-butyl-4-methylene-2,5-cyclohexadienone
CAS 2607-52-5C15H22O
6-tert-Butyl-2-(hydroxy-tert-butyl)-4-methylene-2,5-cyclohexadienone chemical structure, C15H22O2, CAS 124755-19-7
6-tert-Butyl-2-(hydroxy-tert-butyl)-4-methylene-2,5-cyclohexadienone
CAS 124755-19-7C15H22O2
Quinone methide chemical structure, C7H6O, CAS 138230-21-4
Quinone methide
CAS 138230-21-4C7H6O
4-[[Hydroxy(methyl)amino]methylidene]cyclohexa-2,5-dien-1-one chemical structure, C8H9NO2, CAS 16089-67-1
4-[[Hydroxy(methyl)amino]methylidene]cyclohexa-2,5-dien-1-one
CAS 16089-67-1C8H9NO2
2,6-Ditert-butyl-4-(1-methylethylidene)-2,5-cyclohexadien-1-one chemical structure, C17H26O, CAS 5427-02-1
2,6-Ditert-butyl-4-(1-methylethylidene)-2,5-cyclohexadien-1-one
CAS 5427-02-1C17H26O
2,6-Ditert-butyl-4-(dichloromethylidene)cyclohexa-2,5-dien-1-one chemical structure, C15H20Cl2O, CAS 34959-61-0
2,6-Ditert-butyl-4-(dichloromethylidene)cyclohexa-2,5-dien-1-one
CAS 34959-61-0C15H20Cl2O
2,6-Ditert-butyl-4-[[tert-butyl(hydroxy)amino]methylidene]cyclohexa-2,5-dien-1-one chemical structure, C19H31NO2, CAS 29211-05-0
2,6-Ditert-butyl-4-[[tert-butyl(hydroxy)amino]methylidene]cyclohexa-2,5-dien-1-one
CAS 29211-05-0C19H31NO2
2,6-Di-tert-butyl-4-(1-methoxyethylidene)cyclohexa-2,5-dien-1-one chemical structure, C17H26O2, CAS 7470-85-1
2,6-Di-tert-butyl-4-(1-methoxyethylidene)cyclohexa-2,5-dien-1-one
CAS 7470-85-1C17H26O2
4-[Bis(diethoxyphosphoryl)methylidene]-2,6-ditert-butylcyclohexa-2,5-dien-1-one chemical structure, C23H40O7P2, CAS 125931-54-6
4-[Bis(diethoxyphosphoryl)methylidene]-2,6-ditert-butylcyclohexa-2,5-dien-1-one
CAS 125931-54-6C23H40O7P2
N-Acetyldopamine quinone methide chemical structure, C10H11NO3, CAS 117333-16-1
N-Acetyldopamine quinone methide
CAS 117333-16-1C10H11NO3
(3-Hydroxy-4-oxo-2,5-cyclohexadiene-1-ylidene)acetonitrile chemical structure, C8H5NO2, CAS 643726-99-2
(3-Hydroxy-4-oxo-2,5-cyclohexadiene-1-ylidene)acetonitrile
CAS 643726-99-2C8H5NO2
2,6-Bis(1,1-dimethylethyl)-4-(methoxymethylene)-2,5-cyclohexadien-1-one chemical structure, C16H24O2, CAS 20357-48-6
2,6-Bis(1,1-dimethylethyl)-4-(methoxymethylene)-2,5-cyclohexadien-1-one
CAS 20357-48-6C16H24O2
2,5-Cyclohexadien-1-one, 4-(1-methylethylidene)- chemical structure, C9H10O, CAS 55182-48-4
2,5-Cyclohexadien-1-one, 4-(1-methylethylidene)-
CAS 55182-48-4C9H10O
2,5-Cyclohexadien-1-one, 2-methoxy-4-methylene- chemical structure, C8H8O2, CAS 55182-58-6
2,5-Cyclohexadien-1-one, 2-methoxy-4-methylene-
CAS 55182-58-6C8H8O2
2,5-Cyclohexadien-1-one, 2-bromo-6-methoxy-4-methylene- chemical structure, C8H7BrO2, CAS 55182-55-3
2,5-Cyclohexadien-1-one, 2-bromo-6-methoxy-4-methylene-
CAS 55182-55-3C8H7BrO2
2,5-Cyclohexadien-1-one, 2-methoxy-4-(1-methylethylidene)- chemical structure, C10H12O2, CAS 55182-60-0
2,5-Cyclohexadien-1-one, 2-methoxy-4-(1-methylethylidene)-
CAS 55182-60-0C10H12O2
2,5-Cyclohexadien-1-one, 2,6-dimethoxy-4-(1-methylethylidene)- chemical structure, C11H14O3, CAS 55182-52-0
2,5-Cyclohexadien-1-one, 2,6-dimethoxy-4-(1-methylethylidene)-
CAS 55182-52-0C11H14O3
2,5-Cyclohexadien-1-one, 2-bromo-6-methoxy-4-(1-methylethylidene)- chemical structure, C10H11BrO2, CAS 55182-57-5
2,5-Cyclohexadien-1-one, 2-bromo-6-methoxy-4-(1-methylethylidene)-
CAS 55182-57-5C10H11BrO2
2,5-Cyclohexadien-1-one, 2,3,5,6-tetramethyl-4-methylene- chemical structure, C11H14O, CAS 92916-95-5
2,5-Cyclohexadien-1-one, 2,3,5,6-tetramethyl-4-methylene-
CAS 92916-95-5C11H14O
2,6-Dimethoxy-4-methylidenecyclohexa-2,5-dien-1-one chemical structure, C9H10O3, CAS 55182-50-8
2,6-Dimethoxy-4-methylidenecyclohexa-2,5-dien-1-one
CAS 55182-50-8C9H10O3
2,6-Dimethoxy-4-(prop-2-en-1-ylidene)cyclohexa-2,5-dien-1-one chemical structure, C11H12O3, CAS 58623-87-3
2,6-Dimethoxy-4-(prop-2-en-1-ylidene)cyclohexa-2,5-dien-1-one
CAS 58623-87-3C11H12O3
4-Ethylidenecyclohexa-2,5-dien-1-one chemical structure, C8H8O, CAS 55182-47-3
4-Ethylidenecyclohexa-2,5-dien-1-one
CAS 55182-47-3C8H8O
3-[3,5-Bis(1,1-dimethylethyl)-4-oxo-2,5-cyclohexadien-1-ylidene]-2,4-pentanedione chemical structure, C19H26O3, CAS 139978-29-3
3-[3,5-Bis(1,1-dimethylethyl)-4-oxo-2,5-cyclohexadien-1-ylidene]-2,4-pentanedione
CAS 139978-29-3C19H26O3