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Murcko scaffold

N-Phenyltetrahydroisoquinoline scaffold

98 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
98
With full pages
6
Scaffold SMILES

c1ccc(N2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyltetrahydroisoquinoline page
Murcko scaffold c1ccc(N2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 98 chemicals

6,7-Dimethoxy-1-methyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H21NO2, CAS 65492-84-4
6,7-Dimethoxy-1-methyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 65492-84-4C18H21NO2
Benzenamide, 4-(3,4-dihydro-6,7-dimethoxy-1-methyl-2(1H)-isoquinolinyl)-, (S)- chemical structure, C18H22N2O2, CAS 65492-86-6
Benzenamide, 4-(3,4-dihydro-6,7-dimethoxy-1-methyl-2(1H)-isoquinolinyl)-, (S)-
CAS 65492-86-6C18H22N2O2
6,7-Dimethoxy-1-methyl-2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H20N2O4, CAS 65492-87-7
6,7-Dimethoxy-1-methyl-2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline
CAS 65492-87-7C18H20N2O4
1,2,3,4-Tetrahydro-2-[2-nitro-4-(trifluoromethyl)phenyl]isoquinoline chemical structure, C16H13F3N2O2, CAS 165615-46-3
1,2,3,4-Tetrahydro-2-[2-nitro-4-(trifluoromethyl)phenyl]isoquinoline
CAS 165615-46-3C16H13F3N2O2
1-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-nitrophenyl]ethanone chemical structure, C17H16N2O3, CAS 882267-18-7
1-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-nitrophenyl]ethanone
CAS 882267-18-7C17H16N2O3
N-(tert-Butyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide chemical structure, C21H21F3N4O5, CAS 318256-35-8
N-(tert-Butyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
CAS 318256-35-8C21H21F3N4O5
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-5-nitrobenzonitrile chemical structure, C16H13N3O2, CAS 876547-50-1
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-5-nitrobenzonitrile
CAS 876547-50-1C16H13N3O2
4-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-nitrobenzaldehyde chemical structure, C16H14N2O3, CAS 695191-67-4
4-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-nitrobenzaldehyde
CAS 695191-67-4C16H14N2O3
2-(4-Fluoro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline chemical structure, C17H17FN2O4, CAS 879445-23-5
2-(4-Fluoro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline
CAS 879445-23-5C17H17FN2O4
4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-nitrobenzamide chemical structure, C18H19N3O5, CAS 749877-82-5
4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-nitrobenzamide
CAS 749877-82-5C18H19N3O5
Thiourea, [4-(3,4-dihydro-2(1H)-isoquinolinyl)-3-fluorophenyl]- chemical structure, C16H16FN3S, CAS 832098-93-8
Thiourea, [4-(3,4-dihydro-2(1H)-isoquinolinyl)-3-fluorophenyl]-
CAS 832098-93-8C16H16FN3S
1,2,3,4-Tetrahydro-6-nitro-2-phenylisoquinoline chemical structure, C15H14N2O2, CAS 207804-96-4
1,2,3,4-Tetrahydro-6-nitro-2-phenylisoquinoline
CAS 207804-96-4C15H14N2O2
1-Cyano-N-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C16H14N2, CAS 55662-89-0
1-Cyano-N-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 55662-89-0C16H14N2
N-Phenyltetrahydroisoquinoline chemical structure, C15H15N, CAS 3340-78-1
N-Phenyltetrahydroisoquinoline
CAS 3340-78-1C15H15N
Isoquinoline,1,2,3,4-tetrahydro-2-(2-methoxyphenyl)- chemical structure, C16H17NO, CAS 3340-37-2
Isoquinoline,1,2,3,4-tetrahydro-2-(2-methoxyphenyl)-
CAS 3340-37-2C16H17NO
Isoquinoline, 1,2,3,4-tetrahydro-1-(1-octynyl)-2-phenyl- chemical structure, C23H27N, CAS 823814-02-4
Isoquinoline, 1,2,3,4-tetrahydro-1-(1-octynyl)-2-phenyl-
CAS 823814-02-4C23H27N
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-phenyl-, 1,1-dimethylethyl ester chemical structure, C20H23NO2, CAS 401504-07-2
1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-phenyl-, 1,1-dimethylethyl ester
CAS 401504-07-2C20H23NO2
5-Amino-2-(3,4-dihydro-2(1H)-isoquinolinyl)benzoic acid chemical structure, C16H16N2O2, CAS 78243-76-2
5-Amino-2-(3,4-dihydro-2(1H)-isoquinolinyl)benzoic acid
CAS 78243-76-2C16H16N2O2
[2-(4-Nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phosphonic acid chemical structure, C15H15N2O5P, CAS 87993-04-2
[2-(4-Nitrophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]phosphonic acid
CAS 87993-04-2C15H15N2O5P
2-Methyl-2-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium iodide chemical structure, C16H18IN, CAS 78317-77-8
2-Methyl-2-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium iodide
CAS 78317-77-8C16H18IN
1-(tert-Butylperoxy)-2-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H23NO2, CAS 114021-48-6
1-(tert-Butylperoxy)-2-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 114021-48-6C19H23NO2
2-(4-Methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C16H17NO, CAS 78317-83-6
2-(4-Methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline
CAS 78317-83-6C16H17NO
2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)aniline chemical structure, C15H16N2, CAS 246247-91-6
2-(1,2,3,4-Tetrahydroisoquinolin-2-yl)aniline
CAS 246247-91-6C15H16N2
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-5-(trifluoromethyl)aniline chemical structure, C16H15F3N2, CAS 175134-94-8
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-5-(trifluoromethyl)aniline
CAS 175134-94-8C16H15F3N2