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Murcko scaffold

Ring system with 3 rings and 22 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
8
With full pages
3
Scaffold SMILES

O=C(Nc1nccs1)C1CCCN1S(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nccs1)C1CCCN1S(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

(2S)-1-(4-Chlorophenyl)sulfonyl-N-(1,3-thiazol-2-yl)pyrrolidine-2-carboxamide chemical structure, C14H14ClN3O3S2, CAS 374571-69-4
(2S)-1-(4-Chlorophenyl)sulfonyl-N-(1,3-thiazol-2-yl)pyrrolidine-2-carboxamide
CAS 374571-69-4C14H14ClN3O3S2
1-[(4-Fluorophenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide chemical structure, C14H14FN3O3S2, CAS 1008865-64-2
1-[(4-Fluorophenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide
CAS 1008865-64-2C14H14FN3O3S2
1-[(4-Methoxyphenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide chemical structure, C15H17N3O4S2, CAS 1009544-80-2
1-[(4-Methoxyphenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide
CAS 1009544-80-2C15H17N3O4S2
N-(Thiazol-2-yl)-1-tosylpyrrolidine-2-carboxamide chemical structure, C15H17N3O3S2, CAS 1095530-73-6
N-(Thiazol-2-yl)-1-tosylpyrrolidine-2-carboxamide
CAS 1095530-73-6C15H17N3O3S2
1-[(4-Ethoxyphenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide chemical structure, C16H19N3O4S2, CAS 1009764-37-7
1-[(4-Ethoxyphenyl)sulfonyl]-N-1,3-thiazol-2-ylprolinamide
CAS 1009764-37-7C16H19N3O4S2
N-(4,5-Dimethylthiazol-2-yl)-1-tosylpyrrolidine-2-carboxamide chemical structure, C17H21N3O3S2, CAS 1047976-47-5
N-(4,5-Dimethylthiazol-2-yl)-1-tosylpyrrolidine-2-carboxamide
CAS 1047976-47-5C17H21N3O3S2
Ethyl (2Z)-2-{[(Z)-1-(4-fluorobenzene-1-sulfonyl)prolyl]imino}-3,4-dimethyl-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C19H22FN3O5S2, CAS 1048652-59-0
Ethyl (2Z)-2-{[(Z)-1-(4-fluorobenzene-1-sulfonyl)prolyl]imino}-3,4-dimethyl-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 1048652-59-0C19H22FN3O5S2
Ethyl (2Z)-2-{[(Z)-1-(4-chlorobenzene-1-sulfonyl)prolyl]imino}-3,4-dimethyl-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C19H22ClN3O5S2, CAS 1048658-27-0
Ethyl (2Z)-2-{[(Z)-1-(4-chlorobenzene-1-sulfonyl)prolyl]imino}-3,4-dimethyl-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 1048658-27-0C19H22ClN3O5S2