Murcko scaffold
Ring system with 4 rings and 18 atoms
18 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 18
- Chemicals
- 18
- With full pages
- 3
Scaffold SMILES
c1ccc(C2c3ccccc3C3=NCCN32)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 18 of 18 chemicals
Mazindol
CAS 22232-71-9C16H13ClN2O
2,5-Dihydro-5-phenyl-3H-imidazo(2,1-a)isoindol-5-ol
CAS 16780-88-4C16H14N2O
5-(3,4-Dichlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol
CAS 23915-26-6C16H12Cl2N2O
5H-Imidazo(2,1-a)isoindol-5-ol, 2,3-dihydro-5-(alpha,alpha,alpha-trifluoro-p-tolyl)-
CAS 24033-18-9C17H13F3N2O
2,3-Dihydro-5-(p-fluorophenyl)-5H-imidazo(2,1-a)isoindol-5-ol
CAS 26859-72-3C16H13FN2O
5-m-Chlorophenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindol-5-ol
CAS 27097-43-4C16H13ClN2O
3H-Imidazo(2,1-a)isoindol-5-ol, 2,5-dihydro-6-chloro-5-phenyl-
CAS 27097-44-5C16H13ClN2O
5H-Imidazo(2,1-a)isoindol-5-ol, 2,3-dihydro-7-fluoro-5-phenyl-
CAS 27097-50-3C16H13FN2O
3H-Imidazo(2,1-a)isoindol-5-ol, 2,5-dihydro-5-(4-methoxyphenyl)-
CAS 33156-84-2C17H16N2O2
Mazindol hydrochloride
CAS 58535-70-9C16H14Cl2N2O
![5-(4-Bromophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H13BrN2O, CAS 50800-56-1](/s/RAZRHYOBZPAGEG-UHFFFAOYSA-N.svg)
5-(4-Bromophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS 50800-56-1C16H13BrN2O
![5-(2,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H12Cl2N2O, CAS 81450-58-0](/s/QGGJQGSZPWIKSW-UHFFFAOYSA-N.svg)
5-(2,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS 81450-58-0C16H12Cl2N2O
![7-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H13ClN2O, CAS 27097-49-0](/s/TXMKWLMXNSUAPQ-UHFFFAOYSA-N.svg)
7-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS 27097-49-0C16H13ClN2O
![5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H13FN2O, CAS 81450-57-9](/s/DDLGWLKMBTVFGU-UHFFFAOYSA-N.svg)
5-(2-Fluorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS 81450-57-9C16H13FN2O
![2,5-Dihydro-5-(4-hydroxyphenyl)-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H14N2O2, CAS 60232-87-3](/s/JSXQGTAFHHXSKU-UHFFFAOYSA-N.svg)
2,5-Dihydro-5-(4-hydroxyphenyl)-3H-imidazo[2,1-a]isoindol-5-ol
CAS 60232-87-3C16H14N2O2
Mazindol, (S)-
CAS 1337994-13-4C16H13ClN2O
![5-(4-Chlorophenyl)(2,2,3,3-~2~H_4_)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol chemical structure, C16H13ClN2O, CAS 1246815-50-8](/s/ZPXSCAKFGYXMGA-YQUBHJMPSA-N.svg)
5-(4-Chlorophenyl)(2,2,3,3-~2~H_4_)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
CAS 1246815-50-8C16H13ClN2O
Mazindol, (R)-
CAS 1337994-14-5C16H13ClN2O
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(-c2c3ccccc3n3[n+]2CCC3)cc1](/scaffold/HWYVFNDFCCAFII-UHFFFAOYSA-N/structure.svg)