Murcko scaffold
Ring system with 3 rings and 26 atoms
92 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 26
- Chemicals
- 92
- With full pages
- 2
Scaffold SMILES
O=C(CN(C1CCCCC1)S(=O)(=O)c1ccccc1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 92 chemicals
![N-(4-Bromophenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C21H25BrN2O3S, CAS 431054-36-3](/s/GGQJBMNLTDCQEA-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 431054-36-3C21H25BrN2O3S
![2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,4-dichlorophenyl)acetamide chemical structure, C20H21Cl2FN2O3S, CAS 496940-08-0](/s/LIKYVYSSFBQYHJ-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,4-dichlorophenyl)acetamide
CAS 496940-08-0C20H21Cl2FN2O3S
![2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,3-dichlorophenyl)acetamide chemical structure, C20H21Cl2FN2O3S, CAS 496940-09-1](/s/ADRFUYSBZPKOOL-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,3-dichlorophenyl)acetamide
CAS 496940-09-1C20H21Cl2FN2O3S
![2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(4-fluorophenyl)acetamide chemical structure, C20H22F2N2O3S, CAS 433251-45-7](/s/OQJWYQZCIUTRAV-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(4-fluorophenyl)acetamide
CAS 433251-45-7C20H22F2N2O3S
![2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2,6-dimethylphenyl)acetamide chemical structure, C22H27BrN2O3S, CAS 433252-17-6](/s/DTJAITBPJWGIKJ-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2,6-dimethylphenyl)acetamide
CAS 433252-17-6C22H27BrN2O3S
![2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2-ethoxyphenyl)acetamide chemical structure, C22H27BrN2O4S, CAS 433241-18-0](/s/XULVTZLXVWBPFN-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2-ethoxyphenyl)acetamide
CAS 433241-18-0C22H27BrN2O4S
![2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(4-chlorophenyl)acetamide chemical structure, C20H22BrClN2O3S, CAS 428852-14-6](/s/LHLTWWWKZSKKDB-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(4-chlorophenyl)acetamide
CAS 428852-14-6C20H22BrClN2O3S
![N-(4-Chlorophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide chemical structure, C20H22Cl2N2O3S, CAS 431884-50-3](/s/HCDVTKVLCWGYAF-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide
CAS 431884-50-3C20H22Cl2N2O3S
![2-[(4-Chlorophenyl)sulfonyl-cyclohexylamino]-N-(2-methylphenyl)acetamide chemical structure, C21H25ClN2O3S, CAS 431070-26-7](/s/BFEVCCARUNEUSU-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)sulfonyl-cyclohexylamino]-N-(2-methylphenyl)acetamide
CAS 431070-26-7C21H25ClN2O3S
![2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(4-propan-2-ylphenyl)acetamide chemical structure, C24H32N2O3S, CAS 431890-43-6](/s/LFZZHIHHGUDIFC-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(4-propan-2-ylphenyl)acetamide
CAS 431890-43-6C24H32N2O3S
![N-(4-Chloro-2-methylphenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide chemical structure, C21H24Cl2N2O3S, CAS 431055-64-0](/s/VVOYWUCSWDPAIT-UHFFFAOYSA-N.svg)
N-(4-Chloro-2-methylphenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide
CAS 431055-64-0C21H24Cl2N2O3S
![N-(2-Bromophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide chemical structure, C20H22BrClN2O3S, CAS 431071-97-5](/s/VJHLGMDSHQXAMK-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide
CAS 431071-97-5C20H22BrClN2O3S
![N-(5-Chloro-2-methylphenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C22H27ClN2O3S, CAS 431924-97-9](/s/NJSQFVMMWLKJSO-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methylphenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 431924-97-9C22H27ClN2O3S
![N-(3-Bromophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide chemical structure, C20H22BrClN2O3S, CAS 431056-71-2](/s/UOLRZDWCTXFBJR-UHFFFAOYSA-N.svg)
N-(3-Bromophenyl)-2-[(4-chlorophenyl)sulfonyl-cyclohexylamino]acetamide
CAS 431056-71-2C20H22BrClN2O3S
![2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(2-ethylphenyl)acetamide chemical structure, C23H30N2O3S, CAS 431883-90-8](/s/FFBWMZKLQPCHRH-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(2-ethylphenyl)acetamide
CAS 431883-90-8C23H30N2O3S
![N-(4-Chlorophenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C21H25ClN2O3S, CAS 431924-43-5](/s/NSGSHFJDZOLTCP-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 431924-43-5C21H25ClN2O3S
![N-(2-Bromophenyl)-2-{cyclohexyl[(4-methylphenyl)sulfonyl]amino}acetamide chemical structure, C21H25BrN2O3S, CAS 431070-69-8](/s/GBLADDYAYCCOGK-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-2-{cyclohexyl[(4-methylphenyl)sulfonyl]amino}acetamide
CAS 431070-69-8C21H25BrN2O3S
![2-[Benzenesulfonyl(cyclohexyl)amino]-N-(2,5-dimethylphenyl)acetamide chemical structure, C22H28N2O3S, CAS 428502-84-5](/s/KQRZFAYXTXJGSQ-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(cyclohexyl)amino]-N-(2,5-dimethylphenyl)acetamide
CAS 428502-84-5C22H28N2O3S
![2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(3-methylphenyl)acetamide chemical structure, C21H25BrN2O3S, CAS 428830-85-7](/s/JQKRXBYEDFPFMD-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(3-methylphenyl)acetamide
CAS 428830-85-7C21H25BrN2O3S
![2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(3-fluorophenyl)acetamide chemical structure, C21H25FN2O3S, CAS 428851-96-1](/s/XOJFYNDOOPETTR-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(3-fluorophenyl)acetamide
CAS 428851-96-1C21H25FN2O3S
![2-[Benzenesulfonyl(cyclohexyl)amino]-N-(3,5-dichlorophenyl)acetamide chemical structure, C20H22Cl2N2O3S, CAS 428837-42-7](/s/QNMMBUGEYGKUPS-UHFFFAOYSA-N.svg)
2-[Benzenesulfonyl(cyclohexyl)amino]-N-(3,5-dichlorophenyl)acetamide
CAS 428837-42-7C20H22Cl2N2O3S
![2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,3-dimethylphenyl)acetamide chemical structure, C22H27FN2O3S, CAS 356094-34-3](/s/XNGARBUFXNHAKE-UHFFFAOYSA-N.svg)
2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2,3-dimethylphenyl)acetamide
CAS 356094-34-3C22H27FN2O3S
![2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2,6-difluorophenyl)acetamide chemical structure, C20H21BrF2N2O3S, CAS 593263-30-0](/s/IHUNAQOMBRTULX-UHFFFAOYSA-N.svg)
2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2,6-difluorophenyl)acetamide
CAS 593263-30-0C20H21BrF2N2O3S
![N-(4-Chloro-3-nitro-phenyl)-2-[cyclohexyl-(toluene-4-sulfonyl)-amino]-acetamide chemical structure, C21H24ClN3O5S, CAS 332156-20-4](/s/VXTNTWYJIYNNFX-UHFFFAOYSA-N.svg)
N-(4-Chloro-3-nitro-phenyl)-2-[cyclohexyl-(toluene-4-sulfonyl)-amino]-acetamide
CAS 332156-20-4C21H24ClN3O5S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(2,4-dimethoxyphenyl)acetamide428842-78-8C22H28N2O5S
- 2-[(4-Bromophenyl)sulfonyl-cyclohexylamino]-N-(2-ethylphenyl)acetamide428838-32-8C22H27BrN2O3S
- 2-[Cyclohexyl-(3,4-dimethoxyphenyl)sulfonylamino]-N-(4-fluorophenyl)acetamide505052-04-0C22H27FN2O5S
- 2-{Cyclohexyl[(4-methylphenyl)sulfonyl]amino}-N-(2,5-dimethoxyphenyl)acetamide431067-62-8C23H30N2O5S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(2,4-dimethylphenyl)acetamide428823-91-0C22H28N2O3S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(3-bromophenyl)acetamide428824-68-4C20H23BrN2O3S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(2-chlorophenyl)acetamide428825-00-7C20H23ClN2O3S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(4-methylphenyl)acetamide428843-10-1C21H26N2O3S
- 2-[Benzenesulfonyl(cyclohexyl)amino]-N-(3-fluorophenyl)acetamide428505-14-0C20H23FN2O3S
- 2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2-ethylphenyl)acetamide433244-78-1C22H27FN2O3S
- N-(2-Chlorophenyl)-2-[cyclohexyl-(3,4-dimethoxyphenyl)sulfonylamino]acetamide434296-84-1C22H27ClN2O5S
- 4-[[2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]acetyl]amino]benzamide500134-13-4C22H27N3O4S
- 2-[Cyclohexyl-(4-fluorophenyl)sulfonylamino]-N-(2-methylsulfanylphenyl)acetamide706769-39-3C21H25FN2O3S2
- N-(5-Chloro-2-methoxyphenyl)-2-(N-cyclohexyl-4-methylphenylsulfonamido)acetamide332163-17-4C22H27ClN2O4S
- 2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(2-ethyl-6-methylphenyl)acetamide675860-96-5C24H32N2O3S
- 2-[(4-Chlorophenyl)sulfonyl-cyclohexylamino]-N-(3,4-dimethylphenyl)acetamide431056-21-2C22H27ClN2O3S
- N-(3-Acetylphenyl)-2-[(4-bromophenyl)sulfonyl-cyclohexylamino]acetamide593243-98-2C22H25BrN2O4S
- Methyl 4-({N-cyclohexyl-N-[(4-methylphenyl)sulfonyl]glycyl}amino)benzoate432536-71-5C23H28N2O5S
- 2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-[2-(trifluoromethyl)phenyl]acetamide431066-08-9C22H25F3N2O3S
- N-(3-Acetylphenyl)-2-[cyclohexyl-(4-fluorophenyl)sulfonylamino]acetamide431076-01-6C22H25FN2O4S
- N-(3-Chlorophenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide757948-71-3C21H25ClN2O3S
- 2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(2-methoxyphenyl)acetamide757948-63-3C22H28N2O4S
- 2-[Cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(2-methylphenyl)acetamide757948-67-7C22H28N2O3S
- N-(3-Chloro-4-methoxyphenyl)-2-[cyclohexyl-(4-methylphenyl)sulfonylamino]acetamide757948-69-9C22H27ClN2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)Nc1ccccc133 chemicals
O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)Nc1cccnc19 chemicals
O=C(COc1ccccc1)N(Cc1ccccc1)c1ccccn15 chemicals
O=C(CN(c1ccccn1)S(=O)(=O)c1ccccc1)Nc1ccccc15 chemicals
O=S(=O)(c1ccccc1)N(CCCN1CCCCC1)c1ccccc13 chemicals
O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)NC1CCCCC13 chemicals
O=C(CN(C(=O)c1ccccc1)C1CCCCC1)Nc1ccccc13 chemicals
O=C(C=Cc1ccccc1)N(Cc1ccccc1)c1ccccn13 chemicals
O=C(NCc1ccccc1)N(Cc1ccccc1)C1CCNCC12 chemicals
O=C(C(=NNS(=O)(=O)c1ccccc1)c1ccccc1)c1ccccc12 chemicals
O=S(=O)(NCC(Nc1ccccc1)c1ccccc1)c1ccccc12 chemicals
O=C(CCC(C(=O)c1ccccc1)c1ccccc1)c1ccccc11 chemical