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Murcko scaffold

Ring system with 2 rings and 23 atoms

10 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
23
Chemicals
10
With full pages
3
Scaffold SMILES

O=C(CNC(=O)OCc1ccccc1)NCCC1CCNC1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)OCc1ccccc1)NCCC1CCNC1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

GC-373 chemical structure, C21H29N3O5, CAS 1333231-44-9
GC-373
CAS 1333231-44-9C21H29N3O5
Benzyl ((2S)-1-(((2S)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate chemical structure, C21H31N3O5, CAS 1333231-43-8
Benzyl ((2S)-1-(((2S)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
CAS 1333231-43-8C21H31N3O5
GC-376 chemical structure, C21H30N3NaO8S, CAS 1416992-39-6
GC-376
CAS 1416992-39-6C21H30N3NaO8S
GC-376 free acid chemical structure, C21H31N3O8S, CAS 1417031-79-8
GC-376 free acid
CAS 1417031-79-8C21H31N3O8S
Methyl (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-3-(2-oxopyrrolidin-3-yl)propanoate chemical structure, C22H31N3O6, CAS 1350624-48-4
Methyl (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-3-(2-oxopyrrolidin-3-yl)propanoate
CAS 1350624-48-4C22H31N3O6
Benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate chemical structure, C21H29N3O5, CAS 1429218-54-1
Benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
CAS 1429218-54-1C21H29N3O5
Coronastat chemical structure, C22H29F3N3NaO8S, CAS 2922281-15-8
Coronastat
CAS 2922281-15-8C22H29F3N3NaO8S
3-Ethynylbenzyl [(2S)-1-[[(2S)-1-Cyano-1-hydroxy-3-[(S)-2-oxo-3-pyrrolidinyl]-2-propyl]amino]-4-methyl-1-oxo-2-pentyl]carbamate chemical structure, C24H30N4O5, CAS 3031765-46-2
3-Ethynylbenzyl [(2S)-1-[[(2S)-1-Cyano-1-hydroxy-3-[(S)-2-oxo-3-pyrrolidinyl]-2-propyl]amino]-4-methyl-1-oxo-2-pentyl]carbamate
CAS 3031765-46-2C24H30N4O5
Orb2646408 chemical structure, C24H33N3NaO9S, CAS 2816967-14-1
Orb2646408
CAS 2816967-14-1C24H33N3NaO9S
(2S)-1-Hydroxy-2-((S)-4-methyl-2-((((3-(trifluoromethyl)benzyl)oxy)carbonyl)amino)pentanamido)-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonic acid, sodium salt chemical structure, C22H30F3N3NaO8S
(2S)-1-Hydroxy-2-((S)-4-methyl-2-((((3-(trifluoromethyl)benzyl)oxy)carbonyl)amino)pentanamido)-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonic acid, sodium salt
C22H30F3N3NaO8S