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Murcko scaffold

1,2,4-Cyclopentanetrione scaffold

17 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
17
With full pages
3
Scaffold SMILES

O=C1CC(=O)C(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,4-Cyclopentanetrione page
Murcko scaffold O=C1CC(=O)C(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

3-Methyl-1,2,4-cyclopentanetrione chemical structure, C6H6O3, CAS 4505-54-8
3-Methyl-1,2,4-cyclopentanetrione
CAS 4505-54-8C6H6O3
1,2,4-Cyclopentanetrione chemical structure, C5H4O3, CAS 15849-14-6
1,2,4-Cyclopentanetrione
CAS 15849-14-6C5H4O3
3-Butyl-1,2,4-cyclopentanetrione chemical structure, C9H12O3, CAS 46005-09-8
3-Butyl-1,2,4-cyclopentanetrione
CAS 46005-09-8C9H12O3
Ethyl (3-methyl-2,4,5-trioxocyclopentyl)(oxo)acetate chemical structure, C10H10O6, CAS 781-38-4
Ethyl (3-methyl-2,4,5-trioxocyclopentyl)(oxo)acetate
CAS 781-38-4C10H10O6
1,2,4-Cyclopentanetrione, 3-isopentyl-5-isovaleryl-3-(3-methyl-2-butenyl)- chemical structure, C20H30O4, CAS 1891-39-0
1,2,4-Cyclopentanetrione, 3-isopentyl-5-isovaleryl-3-(3-methyl-2-butenyl)-
CAS 1891-39-0C20H30O4
Cohulupone chemical structure, C19H26O4, CAS 1891-34-5
Cohulupone
CAS 1891-34-5C19H26O4
3,3-Dimethyl-1,2,4-cyclopentanetrione chemical structure, C7H8O3, CAS 17530-56-2
3,3-Dimethyl-1,2,4-cyclopentanetrione
CAS 17530-56-2C7H8O3
1,2,4-Cyclopentanetrione, 3-(1-methylbutyl)- chemical structure, C10H14O3, CAS 54644-19-8
1,2,4-Cyclopentanetrione, 3-(1-methylbutyl)-
CAS 54644-19-8C10H14O3
3-Methyl-5-propionyl-1,2,4-cyclopentanetrione chemical structure, C9H10O4, CAS 57174-14-8
3-Methyl-5-propionyl-1,2,4-cyclopentanetrione
CAS 57174-14-8C9H10O4
3-((2E)-Pent-2-en-1-yl)cyclopentane-1,2,4-trione chemical structure, C10H12O3, CAS 54644-27-8
3-((2E)-Pent-2-en-1-yl)cyclopentane-1,2,4-trione
CAS 54644-27-8C10H12O3
Ethyl 7-(2,3,5-trioxocyclopentyl)heptanoate chemical structure, C14H20O5, CAS 23535-00-4
Ethyl 7-(2,3,5-trioxocyclopentyl)heptanoate
CAS 23535-00-4C14H20O5
Methyl 7-(2,3,5-trioxocyclopentyl)heptanoate chemical structure, C13H18O5, CAS 41138-63-0
Methyl 7-(2,3,5-trioxocyclopentyl)heptanoate
CAS 41138-63-0C13H18O5
3-Ethylcyclopentane-1,2,4-trione chemical structure, C7H8O3, CAS 4505-53-7
3-Ethylcyclopentane-1,2,4-trione
CAS 4505-53-7C7H8O3
Methyl 7-(2,3,5-trioxocyclopentyl)hept-5-enoate chemical structure, C13H16O5, CAS 42541-92-4
Methyl 7-(2,3,5-trioxocyclopentyl)hept-5-enoate
CAS 42541-92-4C13H16O5
Ethyl 2-(3-methyl-2,4,5-trioxo-cyclopentyl)-2-oxo-acetate chemical structure, C10H12NaO10S+, CAS 15304-11-7
Ethyl 2-(3-methyl-2,4,5-trioxo-cyclopentyl)-2-oxo-acetate
CAS 15304-11-7C10H12NaO10S+
Diethyl 2,4,5-trioxo-1,3-cyclopentanedicarboxylate chemical structure, C11H12O7, CAS 37951-06-7
Diethyl 2,4,5-trioxo-1,3-cyclopentanedicarboxylate
CAS 37951-06-7C11H12O7
7-{3-[Methoxy(oxo)acetyl]-2,4,5-trioxocyclopentyl}heptanoic acid chemical structure, C15H18O8, CAS 22935-41-7
7-{3-[Methoxy(oxo)acetyl]-2,4,5-trioxocyclopentyl}heptanoic acid
CAS 22935-41-7C15H18O8