Murcko scaffold
Ring system with 4 rings and 25 atoms
33 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 33
- With full pages
- 3
Scaffold SMILES
O=C(Nc1cc(-c2ccccc2)cs1)c1cc2ccccc2oc1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 33 of 33 chemicals
![Ethyl 2-{[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate chemical structure, C26H23NO7S, CAS 444908-84-3](/s/IXFYNTYZFAXCHW-UHFFFAOYSA-N.svg)
Ethyl 2-{[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate
CAS 444908-84-3C26H23NO7S
![N-[4-(4-tert-Butylphenyl)-3-carbamoyl-5-methylthiophen-2-yl]-2-oxochromene-3-carboxamide chemical structure, C26H24N2O4S, CAS 444923-70-0](/s/MSZMEVJSBLHSCL-UHFFFAOYSA-N.svg)
N-[4-(4-tert-Butylphenyl)-3-carbamoyl-5-methylthiophen-2-yl]-2-oxochromene-3-carboxamide
CAS 444923-70-0C26H24N2O4S
![Methyl 4-(3-chlorophenyl)-5-methyl-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate chemical structure, C23H16ClNO5S, CAS 514857-08-0](/s/SKQQTFXXDAQZGB-UHFFFAOYSA-N.svg)
Methyl 4-(3-chlorophenyl)-5-methyl-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate
CAS 514857-08-0C23H16ClNO5S
![Methyl 4-(4-ethoxyphenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C24H19NO6S, CAS 444937-24-0](/s/YJHYFONMWMFLEI-UHFFFAOYSA-N.svg)
Methyl 4-(4-ethoxyphenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3-thiophenecarboxylate
CAS 444937-24-0C24H19NO6S
![Methyl 4-(2,4-dimethylphenyl)-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate chemical structure, C24H19NO5S, CAS 445016-12-6](/s/STHDELVEGYEFDB-UHFFFAOYSA-N.svg)
Methyl 4-(2,4-dimethylphenyl)-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate
CAS 445016-12-6C24H19NO5S
![Methyl 5-methyl-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-phenylthiophene-3-carboxylate chemical structure, C23H17NO5S, CAS 445018-23-5](/s/YBGXLSMUBVDVIW-UHFFFAOYSA-N.svg)
Methyl 5-methyl-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-phenylthiophene-3-carboxylate
CAS 445018-23-5C23H17NO5S
Ethyl 2-(2-oxo-2H-chromene-3-carboxamido)-4-phenylthiophene-3-carboxylate
CAS 312916-68-0C23H17NO5S
N-(3-Cyano-5-methyl-4-phenylthiophen-2-yl)-2-oxochromene-3-carboxamide
CAS 496017-48-2C22H14N2O3S
![Ethyl 4-(4-bromophenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C23H16BrNO5S, CAS 380643-78-7](/s/SYHKLGISMHJSCQ-UHFFFAOYSA-N.svg)
Ethyl 4-(4-bromophenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate
CAS 380643-78-7C23H16BrNO5S
![Ethyl 4-(4-chlorophenyl)-2-[(2-oxochromen-3-yl)carbonylamino]thiophene-3-carbo xylate chemical structure, C23H16ClNO5S, CAS 457637-91-1](/s/LQLHAJLOIQSKLX-UHFFFAOYSA-N.svg)
Ethyl 4-(4-chlorophenyl)-2-[(2-oxochromen-3-yl)carbonylamino]thiophene-3-carbo xylate
CAS 457637-91-1C23H16ClNO5S
Ethyl 5-methyl-2-(2-oxo-2H-chromene-3-carboxamido)-4-phenylthiophene-3-carboxylate
CAS 326886-33-3C24H19NO5S
![Ethyl 4-(4-methylphenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C24H19NO5S, CAS 372506-35-9](/s/UFHWVWRZLRXBCC-UHFFFAOYSA-N.svg)
Ethyl 4-(4-methylphenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate
CAS 372506-35-9C24H19NO5S
![Ethyl 2-{[(6-bromo-2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-(4-chlorophenyl)thiophene-3-carboxylate chemical structure, C23H15BrClNO5S, CAS 438218-02-1](/s/QJYLBVQFFYLEDX-UHFFFAOYSA-N.svg)
Ethyl 2-{[(6-bromo-2-oxo-2H-chromen-3-yl)carbonyl]amino}-4-(4-chlorophenyl)thiophene-3-carboxylate
CAS 438218-02-1C23H15BrClNO5S
![Propan-2-yl 5-methyl-4-(4-methylphenyl)-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate chemical structure, C26H23NO5S, CAS 444927-53-1](/s/AHBNSNYBMAXJFY-UHFFFAOYSA-N.svg)
Propan-2-yl 5-methyl-4-(4-methylphenyl)-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate
CAS 444927-53-1C26H23NO5S
![Propan-2-yl 5-methyl-2-[(2-oxochromene-3-carbonyl)amino]-4-phenylthiophene-3-carboxylate chemical structure, C25H21NO5S, CAS 445014-84-6](/s/JMTYXXGQZNLMDY-UHFFFAOYSA-N.svg)
Propan-2-yl 5-methyl-2-[(2-oxochromene-3-carbonyl)amino]-4-phenylthiophene-3-carboxylate
CAS 445014-84-6C25H21NO5S
![Methyl 4-(3,4-dichlorophenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C22H13Cl2NO5S, CAS 445021-54-5](/s/DWOUNAZGGZTZOU-UHFFFAOYSA-N.svg)
Methyl 4-(3,4-dichlorophenyl)-2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}thiophene-3-carboxylate
CAS 445021-54-5C22H13Cl2NO5S
![Methyl 4-(2,4-dichlorophenyl)-5-methyl-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate chemical structure, C23H15Cl2NO5S, CAS 445022-03-7](/s/OXEAPRURVPJMST-UHFFFAOYSA-N.svg)
Methyl 4-(2,4-dichlorophenyl)-5-methyl-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate
CAS 445022-03-7C23H15Cl2NO5S
N-(3-Carbamoyl-5-methyl-4-phenylthiophen-2-yl)-8-methoxy-2-oxochromene-3-carboxamide
CAS 444908-85-4C23H18N2O5S
![Methyl 4-(2,5-dimethylphenyl)-2-{[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}-5-methylthiophene-3-carboxylate chemical structure, C26H23NO6S, CAS 444908-88-7](/s/SHGNCSLAXUNGGD-UHFFFAOYSA-N.svg)
Methyl 4-(2,5-dimethylphenyl)-2-{[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}-5-methylthiophene-3-carboxylate
CAS 444908-88-7C26H23NO6S
![Ethyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(3,4-dimethylphenyl)-5-methylthiophene-3-carboxylate chemical structure, C26H22ClNO5S, CAS 438198-65-3](/s/SJSAXXKAZAYTKB-UHFFFAOYSA-N.svg)
Ethyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(3,4-dimethylphenyl)-5-methylthiophene-3-carboxylate
CAS 438198-65-3C26H22ClNO5S
![Methyl 4-(4-butan-2-ylphenyl)-2-[(8-methoxy-2-oxochromene-3-carbonyl)amino]-5-methylthiophene-3-carboxylate chemical structure, C28H27NO6S, CAS 515872-94-3](/s/LSQKHTCUOBDRRT-UHFFFAOYSA-N.svg)
Methyl 4-(4-butan-2-ylphenyl)-2-[(8-methoxy-2-oxochromene-3-carbonyl)amino]-5-methylthiophene-3-carboxylate
CAS 515872-94-3C28H27NO6S
![N-[4-(4-Butan-2-ylphenyl)-3-cyano-5-methylthiophen-2-yl]-6-chloro-2-oxochromene-3-carboxamide chemical structure, C26H21ClN2O3S, CAS 438199-21-4](/s/MZLHAZKIAHRFAI-UHFFFAOYSA-N.svg)
N-[4-(4-Butan-2-ylphenyl)-3-cyano-5-methylthiophen-2-yl]-6-chloro-2-oxochromene-3-carboxamide
CAS 438199-21-4C26H21ClN2O3S
![Ethyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(4-chlorophenyl)thiophene-3-carboxylate chemical structure, C23H15Cl2NO5S, CAS 438211-30-4](/s/GPKHQPIJZPYJSE-UHFFFAOYSA-N.svg)
Ethyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(4-chlorophenyl)thiophene-3-carboxylate
CAS 438211-30-4C23H15Cl2NO5S
![Propyl 4-(4-butan-2-ylphenyl)-2-[(6-chloro-2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate chemical structure, C28H26ClNO5S, CAS 438198-00-6](/s/SHYISQSWUGHHRG-UHFFFAOYSA-N.svg)
Propyl 4-(4-butan-2-ylphenyl)-2-[(6-chloro-2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate
CAS 438198-00-6C28H26ClNO5S
- Propyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(2,4-dichlorophenyl)thiophene-3-carboxylate438199-04-3C24H16Cl3NO5S
- Methyl 2-[(2-oxochromene-3-carbonyl)amino]-4-(4-propylphenyl)thiophene-3-carboxylate444908-94-5C25H21NO5S
- Propyl 4-(4-tert-butylphenyl)-2-[(8-ethoxy-2-oxochromene-3-carbonyl)amino]-5-methylthiophene-3-carboxylate438212-97-6C31H33NO6S
- 6-Bromo-N-[3-cyano-4-(4-methoxyphenyl)-5-methylthiophen-2-yl]-2-oxochromene-3-carboxamide438219-23-9C23H15BrN2O4S
- Ethyl 2-[(6-bromo-2-oxochromene-3-carbonyl)amino]-4-(2,5-dimethylphenyl)-5-methylthiophene-3-carboxylate438218-21-4C26H22BrNO5S
- Propan-2-yl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate438198-15-3C24H17ClFNO5S
- Methyl 2-[(6-chloro-2-oxochromene-3-carbonyl)amino]-4-(4-methylphenyl)thiophene-3-carboxylate438211-17-7C23H16ClNO5S
- 6-Bromo-N-[3-carbamoyl-4-(2,4-dichlorophenyl)thiophen-2-yl]-2-oxochromene-3-carboxamide438220-48-5C21H11BrCl2N2O4S
- Ethyl 4-(4-methoxyphenyl)-5-methyl-2-[(2-oxochromene-3-carbonyl)amino]thiophene-3-carboxylate445021-63-6C25H21NO6S
Related scaffolds
Same ring framework with different atoms or bond orders
C(=Cc1ccc2ccccc2n1)c1ccn(-c2ccccc2)c13 chemicals![Scaffold O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1cc(=O)c2ccccc2o1](/scaffold/IRTSNVYIERZQFT-UHFFFAOYSA-N/structure.svg)
O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1cc(=O)c2ccccc2o13 chemicals
O=C1C(N=Nc2ccc3ccccc3c2)C=NN1c1ccccc13 chemicals
O=C(NC1CC(=O)N(c2ccccc2)C1)c1ccc2ccccc2c13 chemicals![Scaffold O=C(Nc1nc(-c2ccccc2)cs1)c1cc2ccccc2[nH]c1=O](/scaffold/KEXDYJQPTRODPT-UHFFFAOYSA-N/structure.svg)
O=C(Nc1nc(-c2ccccc2)cs1)c1cc2ccccc2[nH]c1=O2 chemicals
O=C1CC(NS(=O)(=O)c2ccc3ccccc3c2)CN1c1ccccc12 chemicals
O=C(Nc1ccc2c(c1)OCCO2)c1cnn(-c2ccccc2)n12 chemicals
O=C(Nc1nnc(-c2ccccc2)o1)c1ccc2c(c1)OCCO22 chemicals
O=C(Nc1nc(-c2ccccc2)cs1)C1COc2ccccc2O12 chemicals
c1ccc(-c2cc(COc3ccc4ccccc4c3)no2)cc12 chemicals
O=C(Nc1nnc(-c2ccncc2)o1)c1ccc2ccccc2c12 chemicals![Scaffold O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1ccc2ccccc2c1](/scaffold/ARBDYXHDCUUHIZ-UHFFFAOYSA-N/structure.svg)
O=C(Nc1c[nH]n(-c2ccccc2)c1=O)c1ccc2ccccc2c11 chemical