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Murcko scaffold

N-(4-Phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide scaffold

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
13
With full pages
2
Scaffold SMILES

O=C(Nc1nc(-c2ccccc2)cs1)C1COc2ccccc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(4-Phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide page
Murcko scaffold O=C(Nc1nc(-c2ccccc2)cs1)C1COc2ccccc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

N-(4-Phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H14N2O3S, CAS 307536-59-0
N-(4-Phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 307536-59-0C18H14N2O3S
N-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C19H16N2O3S, CAS 381196-90-3
N-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 381196-90-3C19H16N2O3S
N-(4-(4-Iodophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H13IN2O3S, CAS 850903-26-3
N-(4-(4-Iodophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 850903-26-3C18H13IN2O3S
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C18H13FN2O3S, CAS 515841-79-9
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 515841-79-9C18H13FN2O3S
N-(4-(4-Methoxyphenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H16N2O4S, CAS 381181-82-4
N-(4-(4-Methoxyphenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 381181-82-4C19H16N2O4S
N-(4-(4-Cyanophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H13N3O3S, CAS 681168-42-3
N-(4-(4-Cyanophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 681168-42-3C19H13N3O3S
N-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C20H18N2O5S, CAS 515841-82-4
N-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 515841-82-4C20H18N2O5S
N-(4-(2,5-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H12Cl2N2O3S, CAS 681168-09-2
N-(4-(2,5-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 681168-09-2C18H12Cl2N2O3S
N-(4-(2,4-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H12Cl2N2O3S, CAS 515841-86-8
N-(4-(2,4-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 515841-86-8C18H12Cl2N2O3S
N-(4-(4-Chlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H13ClN2O3S, CAS 515841-78-8
N-(4-(4-Chlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 515841-78-8C18H13ClN2O3S
Ethyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)-4-phenylthiazole-5-carboxylate chemical structure, C21H18N2O5S, CAS 681168-69-4
Ethyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamido)-4-phenylthiazole-5-carboxylate
CAS 681168-69-4C21H18N2O5S
N-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H12Cl2N2O3S, CAS 681168-66-1
N-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 681168-66-1C18H12Cl2N2O3S
N-(5-Methyl-4-phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H16N2O3S, CAS 515841-87-9
N-(5-Methyl-4-phenylthiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 515841-87-9C19H16N2O3S