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Murcko scaffold

Ring system with 4 rings and 36 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
36
Chemicals
20
With full pages
2
Scaffold SMILES

O=C(CNC(=O)C(Cc1ccccc1)NC(=O)CCc1cnc[nH]1)NCCc1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)C(Cc1ccccc1)NC(=O)CCc1cnc[nH]1)NCCc1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

Corticotropin (4-10) chemical structure, C44H59N13O10S, CAS 4037-01-8
Corticotropin (4-10)
CAS 4037-01-8C44H59N13O10S
Acth (4-9) chemical structure, C42H56N12O9S, CAS 56236-83-0
Acth (4-9)
CAS 56236-83-0C42H56N12O9S
Methionyl-arginyl-histidyl-phenylalanyl-tryptophyl-glycine chemical structure, C45H64N16O8S, CAS 43210-80-6
Methionyl-arginyl-histidyl-phenylalanyl-tryptophyl-glycine
CAS 43210-80-6C45H64N16O8S
Glycinamide, L-glutaminyl-L-histidyl-D-phenylalanyl-L-arginyl-D-tryptophyl- chemical structure, C39H52N14O7, CAS 205499-42-9
Glycinamide, L-glutaminyl-L-histidyl-D-phenylalanyl-L-arginyl-D-tryptophyl-
CAS 205499-42-9C39H52N14O7
D-Tryptophan, L-histidyl-D-phenylalanyl-L-arginyl- chemical structure, C32H40N10O5, CAS 170103-04-5
D-Tryptophan, L-histidyl-D-phenylalanyl-L-arginyl-
CAS 170103-04-5C32H40N10O5
3VG23J6Twx chemical structure, C47H65N15O9, CAS 172617-89-9
3VG23J6Twx
CAS 172617-89-9C47H65N15O9
H-His-D-Phe-Arg-Trp-OH chemical structure, C32H40N10O5, CAS 31008-44-3
H-His-D-Phe-Arg-Trp-OH
CAS 31008-44-3C32H40N10O5
L-Tryptophanamide, N-acetyl-L-histidyl-L-phenylalanyl-L-cysteinyl- chemical structure, C31H36N8O5S, CAS 327603-57-6
L-Tryptophanamide, N-acetyl-L-histidyl-L-phenylalanyl-L-cysteinyl-
CAS 327603-57-6C31H36N8O5S
Acetyl hexapeptide-1 chemical structure, C43H59N13O7, CAS 448744-47-6
Acetyl hexapeptide-1
CAS 448744-47-6C43H59N13O7
Ac-[Nle4,D-Phe7]-|A-MSH (4-10)-NH2 chemical structure, C47H64N14O10, CAS 82188-67-8
Ac-[Nle4,D-Phe7]-|A-MSH (4-10)-NH2
CAS 82188-67-8C47H64N14O10
AC-D-Arg-cys-glu-his-D-phe-arg-trp-cys-NH2 chemical structure, C51H72N18O11S2, CAS 819048-44-7
AC-D-Arg-cys-glu-his-D-phe-arg-trp-cys-NH2
CAS 819048-44-7C51H72N18O11S2
L-Histidyl-D-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithyl-L-tryptophanamide chemical structure, C32H41N11O4, CAS 308340-70-7
L-Histidyl-D-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithyl-L-tryptophanamide
CAS 308340-70-7C32H41N11O4
Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2 chemical structure, C49H70N18O9S2, CAS 1304512-91-1
Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2
CAS 1304512-91-1C49H70N18O9S2
(p-Iodo-Phe7)-ACTH (4-10) chemical structure, C44H58IN13O10S, CAS 159600-82-5
(p-Iodo-Phe7)-ACTH (4-10)
CAS 159600-82-5C44H58IN13O10S
HP-228 dihydrochloride chemical structure, C47H67Cl2N15O9, CAS 232601-62-6
HP-228 dihydrochloride
CAS 232601-62-6C47H67Cl2N15O9
N-Acetyl-L-norleucyl-L-glutaminyl-L-histidyl-D-phenylalanyl-L-arginyl-D-tryptophylglycinamide chemical structure, C49H66F3N15O11, CAS 1426174-71-1
N-Acetyl-L-norleucyl-L-glutaminyl-L-histidyl-D-phenylalanyl-L-arginyl-D-tryptophylglycinamide
CAS 1426174-71-1C49H66F3N15O11
Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2.TFA chemical structure, C53H73F3N18O13S2
Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2.TFA
C53H73F3N18O13S2
RO27-3225 Tfa chemical structure, C41H53F3N12O8, CAS 1373926-49-8
RO27-3225 Tfa
CAS 1373926-49-8C41H53F3N12O8
Butanoyl-His-D-Phe-Arg-Trp-Sar-NH2 chemical structure, C39H52N12O6, CAS 274682-89-2
Butanoyl-His-D-Phe-Arg-Trp-Sar-NH2
CAS 274682-89-2C39H52N12O6
Melitane (Acetyl Hexapeptide-1) acetate chemical structure, C45H63N13O9, CAS 2828433-36-7
Melitane (Acetyl Hexapeptide-1) acetate
CAS 2828433-36-7C45H63N13O9