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Murcko scaffold

Ring system with 4 rings and 23 atoms

765 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
765
With full pages
6
Scaffold SMILES

O=C(NCC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 765 chemicals

3-Cyclobutyl-3-([(9H-fluoren-9-ylmethoxy)carbonyl]amino)propanoic acid chemical structure, C22H23NO4, CAS 954225-67-3
3-Cyclobutyl-3-([(9H-fluoren-9-ylmethoxy)carbonyl]amino)propanoic acid
CAS 954225-67-3C22H23NO4
(9H-Fluoren-9-yl)methyl N-[(3-hydroxycyclobutyl)methyl]carbamate chemical structure, C20H21NO3, CAS 1465645-39-9
(9H-Fluoren-9-yl)methyl N-[(3-hydroxycyclobutyl)methyl]carbamate
CAS 1465645-39-9C20H21NO3
(9H-Fluoren-9-yl)methyl N-methyl-N-{[(1s,3s)-3-hydroxycyclobutyl]methyl}carbamate chemical structure, C21H23NO3, CAS 2154324-93-1
(9H-Fluoren-9-yl)methyl N-methyl-N-{[(1s,3s)-3-hydroxycyclobutyl]methyl}carbamate
CAS 2154324-93-1C21H23NO3
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclobutylacetic acid chemical structure, C21H21NO4, CAS 1391630-31-1
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclobutylacetic acid
CAS 1391630-31-1C21H21NO4
(S)-3-(Fmoc-amino)-3-cyclobutylpropanoic acid chemical structure, C22H23NO4, CAS 1260605-23-9
(S)-3-(Fmoc-amino)-3-cyclobutylpropanoic acid
CAS 1260605-23-9C22H23NO4
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclobutylpropanoic acid chemical structure, C22H23NO4, CAS 1260608-72-7
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclobutylpropanoic acid
CAS 1260608-72-7C22H23NO4
2-Cyclobutyl-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)acetic acid chemical structure, C21H21NO4, CAS 1695292-51-3
2-Cyclobutyl-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)acetic acid
CAS 1695292-51-3C21H21NO4
2-{1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}acetic acid chemical structure, C22H23NO4, CAS 1540544-71-5
2-{1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}acetic acid
CAS 1540544-71-5C22H23NO4
(9H-Fluoren-9-yl)methyl (cyclobutylmethyl)hydroxycarbamate chemical structure, C20H21NO3, CAS 198411-67-5
(9H-Fluoren-9-yl)methyl (cyclobutylmethyl)hydroxycarbamate
CAS 198411-67-5C20H21NO3
1-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclobutane-1-carboxylic acid chemical structure, C21H21NO4, CAS 1550436-68-4
1-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclobutane-1-carboxylic acid
CAS 1550436-68-4C21H21NO4
(9H-Fluoren-9-yl)methyl N-[(1-hydroxycyclobutyl)methyl]carbamate chemical structure, C20H21NO3, CAS 1596824-78-0
(9H-Fluoren-9-yl)methyl N-[(1-hydroxycyclobutyl)methyl]carbamate
CAS 1596824-78-0C20H21NO3
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclobutyl)acetic acid chemical structure, C21H19F2NO4, CAS 2097950-77-9
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclobutyl)acetic acid
CAS 2097950-77-9C21H19F2NO4
1-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-3,3-dimethylcyclobutane-1-carboxylic acid chemical structure, C23H25NO4, CAS 2098128-77-7
1-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-3,3-dimethylcyclobutane-1-carboxylic acid
CAS 2098128-77-7C23H25NO4
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methoxycyclobutyl)acetic acid chemical structure, C22H23NO5, CAS 2094133-60-3
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(1-methoxycyclobutyl)acetic acid
CAS 2094133-60-3C22H23NO5
2-Cyclobutyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H23NO4, CAS 1882724-47-1
2-Cyclobutyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1882724-47-1C22H23NO4
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclobutyl)acetic acid chemical structure, C21H19F2NO4, CAS 2350073-06-0
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3,3-difluorocyclobutyl)acetic acid
CAS 2350073-06-0C21H19F2NO4
(2S)-2-(3,3-Difluorocyclobutyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid chemical structure, C21H19F2NO4, CAS 2349734-08-1
(2S)-2-(3,3-Difluorocyclobutyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)acetic acid
CAS 2349734-08-1C21H19F2NO4
(R)-a-(Fmoc-amino)cyclobutaneacetic acid chemical structure, C21H21NO4, CAS 923012-41-3
(R)-a-(Fmoc-amino)cyclobutaneacetic acid
CAS 923012-41-3C21H21NO4
rac-(1R,3S)-3-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-2,2-dimethylcyclobutane-1-carboxylic acid chemical structure, C24H27NO4, CAS 2137439-72-4
rac-(1R,3S)-3-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-2,2-dimethylcyclobutane-1-carboxylic acid
CAS 2137439-72-4C24H27NO4
2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutane-1-carboxylic acid chemical structure, C21H21NO4, CAS 2253640-53-6
2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutane-1-carboxylic acid
CAS 2253640-53-6C21H21NO4
rac-(1r,3r)-3-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-3-fluorocyclobutane-1-carboxylic acid chemical structure, C21H20FNO4, CAS 2287321-48-4
rac-(1r,3r)-3-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-3-fluorocyclobutane-1-carboxylic acid
CAS 2287321-48-4C21H20FNO4
1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3,3-difluorocyclobutane-1-carboxylic acid chemical structure, C21H19F2NO4, CAS 2219409-05-7
1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3,3-difluorocyclobutane-1-carboxylic acid
CAS 2219409-05-7C21H19F2NO4
3-[(9H-Fluoren-9-ylmethoxycarbonylamino)methyl]-3-methoxycyclobutane-1-carboxylic acid chemical structure, C22H23NO5, CAS 2247087-93-8
3-[(9H-Fluoren-9-ylmethoxycarbonylamino)methyl]-3-methoxycyclobutane-1-carboxylic acid
CAS 2247087-93-8C22H23NO5
3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3-hydroxycyclobutane-1-carboxylic acid chemical structure, C21H21NO5, CAS 2402828-94-6
3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3-hydroxycyclobutane-1-carboxylic acid
CAS 2402828-94-6C21H21NO5