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Murcko scaffold

Ring system with 2 rings and 9 atoms

11 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 9
Chemicals: 11
With full pages: 7

Scaffold SMILES

O=C1CC2OC(=O)C2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1CC2OC(=O)C2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione chemical structure, C10H15NO4

1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

C₁₀H₁₅NO₄

(4s,5r)-1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione chemical structure, C10H15NO4, CAS 155975-72-7

(4s,5r)-1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

CAS 155975-72-7C₁₀H₁₅NO₄

clasto-Lactacystin beta-lactone chemical structure, C10H15NO4, CAS 154226-60-5

clasto-Lactacystin beta-lactone

CAS 154226-60-5C₁₀H₁₅NO₄

PS-519 chemical structure, C12H19NO4, CAS 211866-70-5

CAS 211866-70-5C₁₂H₁₉NO₄

alpha-Methylomuralide chemical structure, C11H17NO4, CAS 215232-00-1

alpha-Methylomuralide

CAS 215232-00-1C₁₁H₁₇NO₄

Antiprotealide chemical structure, C12H18ClNO4, CAS 857681-74-4

CAS 857681-74-4C₁₂H₁₈ClNO₄

Calisto-lactone chemical structure, C10H15NO4, CAS 186833-31-8

Calisto-lactone

CAS 186833-31-8C₁₀H₁₅NO₄

(1S,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione chemical structure, C10H15NO4

(1S,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

C₁₀H₁₅NO₄

beta-Clastolactacystin chemical structure, C10H15NO4

beta-Clastolactacystin

C₁₀H₁₅NO₄

(1R,4S,5S)-1-Isobutyl-4,5-dimethyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione chemical structure, C11H17NO3, CAS 1045008-85-2

(1R,4S,5S)-1-Isobutyl-4,5-dimethyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

CAS 1045008-85-2C₁₁H₁₇NO₃

(1S,4S,5R)-1-Isobutyl-4,5-dimethyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione chemical structure, C11H17NO3, CAS 1045008-86-3

(1S,4S,5R)-1-Isobutyl-4,5-dimethyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

CAS 1045008-86-3C₁₁H₁₇NO₃