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Murcko scaffold

2-Pyridin-3-yl-3H-pyrimidin-4-one scaffold

29 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
29
With full pages
7
Scaffold SMILES

O=c1ccnc(-c2cccnc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Pyridin-3-yl-3H-pyrimidin-4-one page
Murcko scaffold O=c1ccnc(-c2cccnc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

Ethyl 4-hydroxy-2-(pyridin-3-yl)pyrimidine-5-carboxylate chemical structure, C12H11N3O3, CAS 34750-63-5
Ethyl 4-hydroxy-2-(pyridin-3-yl)pyrimidine-5-carboxylate
CAS 34750-63-5C12H11N3O3
2-Pyridin-3-yl-3H-pyrimidin-4-one chemical structure, C9H7N3O, CAS 97604-06-3
2-Pyridin-3-yl-3H-pyrimidin-4-one
CAS 97604-06-3C9H7N3O
6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C10H7N3O3, CAS 56406-46-3
6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-5-carboxylic acid
CAS 56406-46-3C10H7N3O3
2-(6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid chemical structure, C11H9N3O3, CAS 1210360-87-4
2-(6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidin-5-yl)acetic acid
CAS 1210360-87-4C11H9N3O3
Methyl 6-oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-5-carboxylate chemical structure, C11H9N3O3, CAS 1239756-97-8
Methyl 6-oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-5-carboxylate
CAS 1239756-97-8C11H9N3O3
N-(5-(4-Hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)pyridin-2-yl)pivalamide chemical structure, C14H16N4O3, CAS 1045861-08-2
N-(5-(4-Hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)pyridin-2-yl)pivalamide
CAS 1045861-08-2C14H16N4O3
2-(Pyridin-3-yl)pyrimidine-4,6-diol chemical structure, C9H7N3O2, CAS 204394-77-4
2-(Pyridin-3-yl)pyrimidine-4,6-diol
CAS 204394-77-4C9H7N3O2
5-Hydroxy-2-pyridin-3-yl-1H-pyrimidin-6-one chemical structure, C9H7N3O2, CAS 1333239-63-6
5-Hydroxy-2-pyridin-3-yl-1H-pyrimidin-6-one
CAS 1333239-63-6C9H7N3O2
2-(Pyridin-3-yl)-6-(trifluoromethyl)pyrimidin-4-ol chemical structure, C10H6F3N3O, CAS 204394-59-2
2-(Pyridin-3-yl)-6-(trifluoromethyl)pyrimidin-4-ol
CAS 204394-59-2C10H6F3N3O
6-Methyl-2-(3-pyridinyl)-4-pyrimidinol chemical structure, C10H9N3O, CAS 16879-57-5
6-Methyl-2-(3-pyridinyl)-4-pyrimidinol
CAS 16879-57-5C10H9N3O
6-((Methylsulfanyl)methyl)-2-(3-pyridinyl)-4-pyrimidinol chemical structure, C11H11N3OS, CAS 478031-30-0
6-((Methylsulfanyl)methyl)-2-(3-pyridinyl)-4-pyrimidinol
CAS 478031-30-0C11H11N3OS
6-(Methoxymethyl)-2-(pyridin-3-yl)pyrimidin-4-ol chemical structure, C11H11N3O2, CAS 339278-99-8
6-(Methoxymethyl)-2-(pyridin-3-yl)pyrimidin-4-ol
CAS 339278-99-8C11H11N3O2
6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-4-carboxylic acid chemical structure, C10H7N3O3, CAS 84660-10-6
6-Oxo-2-(pyridin-3-yl)-1,6-dihydropyrimidine-4-carboxylic acid
CAS 84660-10-6C10H7N3O3
6-Ethyl-2-pyridin-3-ylpyrimidin-4(3H)-one chemical structure, C11H11N3O, CAS 1049874-27-2
6-Ethyl-2-pyridin-3-ylpyrimidin-4(3H)-one
CAS 1049874-27-2C11H11N3O
1,6-Dihydro-4-methyl-6-oxo-2-(3-pyridinyl)-5-pyrimidineacetic acid chemical structure, C12H11N3O3, CAS 1118787-12-4
1,6-Dihydro-4-methyl-6-oxo-2-(3-pyridinyl)-5-pyrimidineacetic acid
CAS 1118787-12-4C12H11N3O3
1,6-Dihydro-4-methyl-6-oxo-2-(3-pyridinyl)-5-pyrimidinepropanoic acid chemical structure, C13H13N3O3, CAS 1221722-39-9
1,6-Dihydro-4-methyl-6-oxo-2-(3-pyridinyl)-5-pyrimidinepropanoic acid
CAS 1221722-39-9C13H13N3O3
2-(6-Chloropyridin-3-yl)-6-methyl-3,4-dihydropyrimidin-4-one chemical structure, C10H8ClN3O, CAS 1258650-38-2
2-(6-Chloropyridin-3-yl)-6-methyl-3,4-dihydropyrimidin-4-one
CAS 1258650-38-2C10H8ClN3O
2-(6-Chloropyridin-3-yl)-6-ethyl-3,4-dihydropyrimidin-4-one chemical structure, C11H10ClN3O, CAS 1258640-17-3
2-(6-Chloropyridin-3-yl)-6-ethyl-3,4-dihydropyrimidin-4-one
CAS 1258640-17-3C11H10ClN3O
2-(6-Chloropyridin-3-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one chemical structure, C11H10ClN3O, CAS 1258650-89-3
2-(6-Chloropyridin-3-yl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one
CAS 1258650-89-3C11H10ClN3O
4-Propan-2-yl-2-pyridin-3-yl-1H-pyrimidin-6-one chemical structure, C12H13N3O, CAS 874783-57-0
4-Propan-2-yl-2-pyridin-3-yl-1H-pyrimidin-6-one
CAS 874783-57-0C12H13N3O
N-(Cyanomethyl)-2-[6-methyl-4-oxo-2-(pyridin-3-yl)-1,4-dihydropyrimidin-5-yl]acetamide chemical structure, C14H13N5O2, CAS 1240933-80-5
N-(Cyanomethyl)-2-[6-methyl-4-oxo-2-(pyridin-3-yl)-1,4-dihydropyrimidin-5-yl]acetamide
CAS 1240933-80-5C14H13N5O2
6-(2-Aminoethyl)-2-(pyridin-3-yl)-3,4-dihydropyrimidin-4-one chemical structure, C11H12N4O, CAS 1266965-73-4
6-(2-Aminoethyl)-2-(pyridin-3-yl)-3,4-dihydropyrimidin-4-one
CAS 1266965-73-4C11H12N4O
Methyl 6-oxo-2-pyridin-3-yl-1H-pyrimidine-4-carboxylate chemical structure, C11H9N3O3, CAS 1244018-35-6
Methyl 6-oxo-2-pyridin-3-yl-1H-pyrimidine-4-carboxylate
CAS 1244018-35-6C11H9N3O3
Ethyl 3-(5-chloro-6-oxo-2-pyridin-3-yl-1H-pyrimidin-4-yl)propanoate chemical structure, C14H14ClN3O3, CAS 1416374-45-2
Ethyl 3-(5-chloro-6-oxo-2-pyridin-3-yl-1H-pyrimidin-4-yl)propanoate
CAS 1416374-45-2C14H14ClN3O3