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Murcko scaffold

Ring system with 6 rings and 19 atoms

71 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
19
Chemicals
71
With full pages
10
Scaffold SMILES

C=C1CN2C3Cc4c([nH]c5ccccc45)C2CC1C3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C=C1CN2C3Cc4c([nH]c5ccccc45)C2CC1C3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 71 chemicals

[(1S,12S,14S)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol chemical structure, C19H22N2O
[(1S,12S,14S)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol
C19H22N2O
Methyl 15-ethylidene-13-(hydroxymethyl)-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraene-13-carboxylate chemical structure, C21H24N2O3
Methyl 15-ethylidene-13-(hydroxymethyl)-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraene-13-carboxylate
C21H24N2O3
16-Epinormacusine B chemical structure, C19H22N2O, CAS 124096-81-7
16-Epinormacusine B
CAS 124096-81-7C19H22N2O
16-Epikoumidine chemical structure, C19H22N2O
16-Epikoumidine
C19H22N2O
[(1S,12S,14R,15E)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol chemical structure, C19H22N2O
[(1S,12S,14R,15E)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol
C19H22N2O
(E)-16-Epinormacusine B chemical structure, C19H22N2O, CAS 126640-98-0
(E)-16-Epinormacusine B
CAS 126640-98-0C19H22N2O
[(15E)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol chemical structure, C19H22N2O
[(15E)-15-Ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-13-yl]methanol
C19H22N2O
Lochnerine chemical structure, C20H24N2O2, CAS 522-47-4
Lochnerine
CAS 522-47-4C20H24N2O2
17-Acetylsarpagine chemical structure, C21H24N2O3, CAS 102358-21-4
17-Acetylsarpagine
CAS 102358-21-4C21H24N2O3
16-Episarpagine chemical structure, C19H22N2O2, CAS 102490-01-7
16-Episarpagine
CAS 102490-01-7C19H22N2O2
11-Methoxymacusine A chemical structure, C23H29N2O4+, CAS 87340-28-1
11-Methoxymacusine A
CAS 87340-28-1C23H29N2O4+
Spegatrine chemical structure, C20H25N2O2+, CAS 47326-53-4
Spegatrine
CAS 47326-53-4C20H25N2O2+
Tombozin chemical structure, C19H22N2O, CAS 604-99-9
Tombozin
CAS 604-99-9C19H22N2O
(16S)-11-Methoxysarpagan-17-ol chemical structure, C20H24N2O2, CAS 23172-92-1
(16S)-11-Methoxysarpagan-17-ol
CAS 23172-92-1C20H24N2O2
Vellosimine chemical structure, C19H20N2O, CAS 6874-98-2
Vellosimine
CAS 6874-98-2C19H20N2O
Sarpagan-17-ol, (16S,19Z)- chemical structure, C19H22N2O, CAS 1358-75-4
Sarpagan-17-ol, (16S,19Z)-
CAS 1358-75-4C19H22N2O
16-Epivellosimine chemical structure, C19H20N2O, CAS 88199-28-4
16-Epivellosimine
CAS 88199-28-4C19H20N2O
Normacusine B chemical structure, C19H22N2O
Normacusine B
C19H22N2O
(1R,12S,13R,14R,15E)-15-Ethylidene-13-(hydroxymethyl)-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraene-1,7-diol chemical structure, C19H22N2O3
(1R,12S,13R,14R,15E)-15-Ethylidene-13-(hydroxymethyl)-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4(9),5,7-tetraene-1,7-diol
C19H22N2O3
Affinisine chemical structure, C20H24N2O, CAS 2912-11-0
Affinisine
CAS 2912-11-0C20H24N2O
Sarpagine chemical structure, C19H22N2O2, CAS 482-68-8
Sarpagine
CAS 482-68-8C19H22N2O2
Voachalotine chemical structure, C22H26N2O3, CAS 664-25-5
Voachalotine
CAS 664-25-5C22H26N2O3
(+)-Normacusine B chemical structure, C19H22N2O
(+)-Normacusine B
C19H22N2O
(19Z)-Normacusine B chemical structure, C19H22N2O
(19Z)-Normacusine B
C19H22N2O