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Murcko scaffold

Ring system with 6 rings and 36 atoms

184 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
36
Chemicals
184
With full pages
9
Scaffold SMILES

O=c1[nH]cnc2c1ncn2C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cnc2c1ncn2C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 184 chemicals

N'-[9-[(2R,4S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-1-methyl-6-oxopurin-2-yl]-N,N-dimethylmethanimidamide chemical structure, C44H55N8O7P, CAS 220252-95-9
N'-[9-[(2R,4S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-1-methyl-6-oxopurin-2-yl]-N,N-dimethylmethanimidamide
CAS 220252-95-9C44H55N8O7P
5'-O-DMT-2'-O-TBDMS-rI chemical structure, C37H44N4O7Si, CAS 127212-34-4
5'-O-DMT-2'-O-TBDMS-rI
CAS 127212-34-4C37H44N4O7Si
4-[[2-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[2-[(2-methyl-1-oxopropyl)amino]-6-oxo-3H-purin-9-yl]-3-oxolanyl]oxy]-4-oxobutanoic acid chemical structure, C39H41N5O10
4-[[2-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[2-[(2-methyl-1-oxopropyl)amino]-6-oxo-3H-purin-9-yl]-3-oxolanyl]oxy]-4-oxobutanoic acid
C39H41N5O10
5'-O-(Bis(4-methoxyphenyl)benzyl)-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine chemical structure, C35H37N5O7, CAS 68892-41-1
5'-O-(Bis(4-methoxyphenyl)benzyl)-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine
CAS 68892-41-1C35H37N5O7
Guanosine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite) chemical structure, C44H54N7O8P, CAS 93183-15-4
Guanosine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-N-(2-methyl-1-oxopropyl)-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite)
CAS 93183-15-4C44H54N7O8P
3'-DG CEP chemical structure, C43H53N8O7P
3'-DG CEP
C43H53N8O7P
Guanosine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite) chemical structure, C44H53FN7O8P, CAS 144089-97-4
Guanosine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite)
CAS 144089-97-4C44H53FN7O8P
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyguanosine chemical structure, C31H31N5O6, CAS 81144-43-6
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyguanosine
CAS 81144-43-6C31H31N5O6
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine chemical structure, C41H51N5O8Si, CAS 81279-39-2
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
CAS 81279-39-2C41H51N5O8Si
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide chemical structure, C35H36FN5O7, CAS 144089-96-3
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
CAS 144089-96-3C35H36FN5O7
(2R,3S,5R)-5-(2-Amino-6-oxo-3H-purin-9(6H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite chemical structure, C40H48N7O7P, CAS 140613-56-5
(2R,3S,5R)-5-(2-Amino-6-oxo-3H-purin-9(6H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS 140613-56-5C40H48N7O7P
5'-DMTr-dG(iBu)-Methyl phosphonamidite chemical structure, C42H53N6O7P, CAS 115131-08-3
5'-DMTr-dG(iBu)-Methyl phosphonamidite
CAS 115131-08-3C42H53N6O7P
2'-O-tert-Butyldimethylsilyl-5'-O-DMT-inosine 3'-CE phosphoramidite chemical structure, C46H61N6O8PSi, CAS 261518-12-1
2'-O-tert-Butyldimethylsilyl-5'-O-DMT-inosine 3'-CE phosphoramidite
CAS 261518-12-1C46H61N6O8PSi
2-TFA-AE G(iBu) amidite chemical structure, C48H58F3N8O10P, CAS 853748-79-5
2-TFA-AE G(iBu) amidite
CAS 853748-79-5C48H58F3N8O10P
2'-Deoxy-5'-O-FDMT-N2-isobutyryl-guanosine 3'-CE phosphoramidite chemical structure, C54H57F17N7O8P
2'-Deoxy-5'-O-FDMT-N2-isobutyryl-guanosine 3'-CE phosphoramidite
C54H57F17N7O8P
5'-O-DMT-rI chemical structure, C31H30N4O7, CAS 119898-59-8
5'-O-DMT-rI
CAS 119898-59-8C31H30N4O7
8-Bromo-5'-O-(dimethoxytrityl)-n2-(dimethylaminomethylidene)-2'-deoxyguanosine chemical structure, C34H35BrN6O6, CAS 204582-53-6
8-Bromo-5'-O-(dimethoxytrityl)-n2-(dimethylaminomethylidene)-2'-deoxyguanosine
CAS 204582-53-6C34H35BrN6O6
8-Amino-DG cep chemical structure, C46H59N10O7P
8-Amino-DG cep
C46H59N10O7P
Orb3180100 chemical structure, C47H60N7O9P, CAS 160526-45-4
Orb3180100
CAS 160526-45-4C47H60N7O9P
5'-O-Tritylinosine chemical structure, C29H26N4O5, CAS 4152-77-6
5'-O-Tritylinosine
CAS 4152-77-6C29H26N4O5
N'-[9-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide chemical structure, C35H38N6O7, CAS 1858223-91-2
N'-[9-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide
CAS 1858223-91-2C35H38N6O7
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]guanosine chemical structure, C31H31N5O7, CAS 17331-23-6
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]guanosine
CAS 17331-23-6C31H31N5O7
5''-O-Trityl-2''deoxyinosine chemical structure, C29H26N4O4, CAS 911430-74-5
5''-O-Trityl-2''deoxyinosine
CAS 911430-74-5C29H26N4O4
2'-OMe-G(ibu) Phosphoramidite chemical structure, C45H56N7O9P, CAS 150780-67-9
2'-OMe-G(ibu) Phosphoramidite
CAS 150780-67-9C45H56N7O9P