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Murcko scaffold

Ring system with 4 rings and 25 atoms

122 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
122
With full pages
3
Scaffold SMILES

O=C(CSC1=Nc2ccccc2C2=NCC(=O)N12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSC1=Nc2ccccc2C2=NCC(=O)N12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 122 chemicals

2-({2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}thio)-N-(2-methoxyphenyl)acetamide chemical structure, C25H27N5O4S, CAS 958964-77-7
2-({2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}thio)-N-(2-methoxyphenyl)acetamide
CAS 958964-77-7C25H27N5O4S
2-({2-[(Butylcarbamoyl)methyl]-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)-N-(3-methylphenyl)acetamide chemical structure, C25H27N5O3S, CAS 958943-16-3
2-({2-[(Butylcarbamoyl)methyl]-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)-N-(3-methylphenyl)acetamide
CAS 958943-16-3C25H27N5O3S
2-({2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}thio)-N-(4-methoxyphenyl)acetamide chemical structure, C25H27N5O4S, CAS 958963-26-3
2-({2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}thio)-N-(4-methoxyphenyl)acetamide
CAS 958963-26-3C25H27N5O4S
N-Butyl-2-(5-((2-((4-isopropylphenyl)amino)-2-oxoethyl)thio)-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-2-yl)acetamide chemical structure, C27H31N5O3S, CAS 1022129-50-5
N-Butyl-2-(5-((2-((4-isopropylphenyl)amino)-2-oxoethyl)thio)-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-2-yl)acetamide
CAS 1022129-50-5C27H31N5O3S
2-[[2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl]-N-(3-methylphenyl)butanamide chemical structure, C27H31N5O3S, CAS 1022234-70-3
2-[[2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl]-N-(3-methylphenyl)butanamide
CAS 1022234-70-3C27H31N5O3S
2-[[2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl]-N-(4-chlorophenyl)butanamide chemical structure, C26H28ClN5O3S, CAS 1022234-95-2
2-[[2-[2-(Butylamino)-2-oxoethyl]-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl]-N-(4-chlorophenyl)butanamide
CAS 1022234-95-2C26H28ClN5O3S
2-[(2-Butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(4-ethylphenyl)acetamide chemical structure, C24H26N4O2S, CAS 1023505-84-1
2-[(2-Butan-2-yl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(4-ethylphenyl)acetamide
CAS 1023505-84-1C24H26N4O2S
N-(2,4-Dimethoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide chemical structure, C23H24N4O4S, CAS 958697-50-2
N-(2,4-Dimethoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide
CAS 958697-50-2C23H24N4O4S
N-(2-Methoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}butanamide chemical structure, C24H26N4O3S, CAS 1023533-20-1
N-(2-Methoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}butanamide
CAS 1023533-20-1C24H26N4O3S
N-(3-Methylphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}butanamide chemical structure, C24H26N4O2S, CAS 1023533-19-8
N-(3-Methylphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}butanamide
CAS 1023533-19-8C24H26N4O2S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide chemical structure, C22H18ClF3N4O2S, CAS 1023533-21-2
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide
CAS 1023533-21-2C22H18ClF3N4O2S
N-(2,4-Dimethoxyphenyl)-2-{[2-(2-methylpropyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide chemical structure, C24H26N4O4S, CAS 1023815-60-2
N-(2,4-Dimethoxyphenyl)-2-{[2-(2-methylpropyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide
CAS 1023815-60-2C24H26N4O4S
N-(4-Ethoxyphenyl)-2-({3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)acetamide chemical structure, C20H18N4O3S, CAS 443673-86-7
N-(4-Ethoxyphenyl)-2-({3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)acetamide
CAS 443673-86-7C20H18N4O3S
N-(4-Ethylphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide chemical structure, C23H24N4O2S, CAS 958142-84-2
N-(4-Ethylphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide
CAS 958142-84-2C23H24N4O2S
N-(3-Methoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide chemical structure, C22H22N4O3S, CAS 957584-75-7
N-(3-Methoxyphenyl)-2-{[3-oxo-2-(propan-2-yl)-2H,3H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl}acetamide
CAS 957584-75-7C22H22N4O3S
2-({2-[(Butylcarbamoyl)methyl]-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)-N-(5-chloro-2-methoxyphenyl)acetamide chemical structure, C25H26ClN5O4S, CAS 958580-92-2
2-({2-[(Butylcarbamoyl)methyl]-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-5-yl}sulfanyl)-N-(5-chloro-2-methoxyphenyl)acetamide
CAS 958580-92-2C25H26ClN5O4S
N-(2,4-Dimethylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide chemical structure, C21H20N4O2S, CAS 1008473-61-7
N-(2,4-Dimethylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide
CAS 1008473-61-7C21H20N4O2S
N-(3,5-Dimethoxyphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide chemical structure, C21H20N4O4S, CAS 1052605-24-9
N-(3,5-Dimethoxyphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide
CAS 1052605-24-9C21H20N4O4S
N-(2,5-Dimethylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide chemical structure, C21H20N4O2S, CAS 1008085-05-9
N-(2,5-Dimethylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide
CAS 1008085-05-9C21H20N4O2S
N-Butyl-3-[5-({[(3-chloro-4-methoxyphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide chemical structure, C26H28ClN5O4S, CAS 1093808-67-3
N-Butyl-3-[5-({[(3-chloro-4-methoxyphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide
CAS 1093808-67-3C26H28ClN5O4S
N-Butyl-3-[5-({[(3-methylphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide chemical structure, C26H29N5O3S, CAS 1093808-97-9
N-Butyl-3-[5-({[(3-methylphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide
CAS 1093808-97-9C26H29N5O3S
N-Butyl-3-[5-({[(3-chlorophenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide chemical structure, C25H26ClN5O3S, CAS 1093808-99-1
N-Butyl-3-[5-({[(3-chlorophenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide
CAS 1093808-99-1C25H26ClN5O3S
N-Butyl-3-[5-({[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide chemical structure, C26H28ClN5O4S, CAS 1093809-24-5
N-Butyl-3-[5-({[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}sulfanyl)-3-oxo-2H,3H-imidazo[1,2-c]quinazolin-2-yl]propanamide
CAS 1093809-24-5C26H28ClN5O4S
N-(3-Fluoro-4-methylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide chemical structure, C20H17FN4O2S, CAS 1053086-81-9
N-(3-Fluoro-4-methylphenyl)-2-((2-methyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetamide
CAS 1053086-81-9C20H17FN4O2S