Murcko scaffold
Ring system with 4 rings and 24 atoms
25 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 25
- With full pages
- 4
Scaffold SMILES
O=c1c2c(ccn1Cc1ccccn1)OC=CC2c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 25 of 25 chemicals
![2-Amino-4-(2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C23H20N4O3, CAS 712296-11-2](/s/KPMFOWCPVGLLKH-UHFFFAOYSA-N.svg)
2-Amino-4-(2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712296-11-2C23H20N4O3
![2-Amino-4-(2,5-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O4, CAS 712296-07-6](/s/TZXDZLWLXNWXRN-UHFFFAOYSA-N.svg)
2-Amino-4-(2,5-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712296-07-6C24H22N4O4
![2-Amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O4, CAS 612053-10-8](/s/WZRZOWPKCUJRRO-UHFFFAOYSA-N.svg)
2-Amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612053-10-8C24H22N4O4
![2-Amino-4-(2,3-diethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C26H26N4O4, CAS 712295-94-8](/s/UKXJSNQTUAJTMV-UHFFFAOYSA-N.svg)
2-Amino-4-(2,3-diethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712295-94-8C26H26N4O4
![2-Amino-4-(5-bromo-2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C23H19BrN4O3, CAS 846587-69-7](/s/RKEYAZIQQDKGRO-UHFFFAOYSA-N.svg)
2-Amino-4-(5-bromo-2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 846587-69-7C23H19BrN4O3
![2-Amino-4-(4-ethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O3, CAS 767300-13-0](/s/FPXHIAGGWDDOHN-UHFFFAOYSA-N.svg)
2-Amino-4-(4-ethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 767300-13-0C24H22N4O3
![2-Amino-4-(3-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17BrN4O2, CAS 758700-66-2](/s/IHAJCOGFEBQPOR-UHFFFAOYSA-N.svg)
2-Amino-4-(3-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-66-2C22H17BrN4O2
![2-Amino-4-(4-isopropylphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O2, CAS 758700-68-4](/s/APSCGDGLKQNLQI-UHFFFAOYSA-N.svg)
2-Amino-4-(4-isopropylphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-68-4C25H24N4O2
![2-Amino-4-(4-ethoxy-3-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O4, CAS 758700-84-4](/s/UNSBIIPGXWPCOB-UHFFFAOYSA-N.svg)
2-Amino-4-(4-ethoxy-3-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-84-4C25H24N4O4
![2-Amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O4, CAS 612053-06-2](/s/YUBGFWXCUDRZJD-UHFFFAOYSA-N.svg)
2-Amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612053-06-2C24H22N4O4
![2-Amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17ClN4O2, CAS 712295-81-3](/s/ATEXBBWXLSUEKR-UHFFFAOYSA-N.svg)
2-Amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712295-81-3C22H17ClN4O2
![2-Amino-4-(2-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17BrN4O2, CAS 758700-80-0](/s/UWFAUOLFWILNPE-UHFFFAOYSA-N.svg)
2-Amino-4-(2-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-80-0C22H17BrN4O2
![2-Amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17ClN4O2, CAS 758700-72-0](/s/ILBCKAWDRDESGB-UHFFFAOYSA-N.svg)
2-Amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-72-0C22H17ClN4O2
![Methyl 2-amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C23H20ClN3O4, CAS 758704-49-3](/s/WVFGFXDXFFADQW-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 758704-49-3C23H20ClN3O4
![2-Amino-4-(3-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C23H20N4O3, CAS 712296-12-3](/s/MOFPJOADUOAWIK-UHFFFAOYSA-N.svg)
2-Amino-4-(3-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712296-12-3C23H20N4O3
![2-Amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17ClN4O2, CAS 712296-08-7](/s/YSBDCNWWYWADDF-UHFFFAOYSA-N.svg)
2-Amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712296-08-7C22H17ClN4O2
![2-Amino-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-4-(2,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O5, CAS 612053-03-9](/s/SNTLFPHQUTVRNV-UHFFFAOYSA-N.svg)
2-Amino-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-4-(2,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612053-03-9C25H24N4O5
![2-Amino-4-(3-bromo-4-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C23H19BrN4O3, CAS 758700-74-2](/s/JAOSRMCAMARAPK-UHFFFAOYSA-N.svg)
2-Amino-4-(3-bromo-4-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-74-2C23H19BrN4O3
![2-Amino-7-methyl-5-oxo-6-(2-pyridinylmethyl)-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O5, CAS 612053-09-5](/s/KHAAAEIBJNTDBO-UHFFFAOYSA-N.svg)
2-Amino-7-methyl-5-oxo-6-(2-pyridinylmethyl)-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612053-09-5C25H24N4O5
![2-Amino-4-(4-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17BrN4O2, CAS 758700-82-2](/s/SVOVFJJCHVEMLK-UHFFFAOYSA-N.svg)
2-Amino-4-(4-bromophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 758700-82-2C22H17BrN4O2
![Methyl 2-amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C23H20ClN3O4, CAS 767299-97-8](/s/VRGYURJKGBQKTJ-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 767299-97-8C23H20ClN3O4
![Methyl 2-amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C25H25N3O6, CAS 767300-00-5](/s/NEWIJCKZLWFZFS-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 767300-00-5C25H25N3O6
![Methyl 2-amino-7-methyl-5-oxo-4-phenyl-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C23H21N3O4, CAS 767300-02-7](/s/WXRHVTXMQQAALE-UHFFFAOYSA-N.svg)
Methyl 2-amino-7-methyl-5-oxo-4-phenyl-6-(pyridin-2-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 767300-02-7C23H21N3O4
![Ethyl 2-amino-4-(2-fluorophenyl)-7-methyl-5-oxo-6-[(pyridin-2-yl)methyl]-4H,5H,6H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C24H22FN3O4, CAS 883488-97-9](/s/ZJCJMNSVYCDIBV-UHFFFAOYSA-N.svg)
Ethyl 2-amino-4-(2-fluorophenyl)-7-methyl-5-oxo-6-[(pyridin-2-yl)methyl]-4H,5H,6H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 883488-97-9C24H22FN3O4
Related scaffolds
Same ring framework with different atoms or bond orders
