Murcko scaffold
Ring system with 4 rings and 24 atoms
15 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 15
- With full pages
- 5
Scaffold SMILES
O=c1c2c(ccn1Cc1cccnc1)OC=CC2c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 15 of 15 chemicals
![Methyl 2-amino-4-(2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C24H23N3O5, CAS 758702-35-1](/s/SAFPDBRESLLUKB-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(2-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 758702-35-1C24H23N3O5
![2-Amino-4-(4-fluorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17FN4O2, CAS 767300-20-9](/s/XKCWDSRFYQPSHB-UHFFFAOYSA-N.svg)
2-Amino-4-(4-fluorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 767300-20-9C22H17FN4O2
![Methyl 2-amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C25H25N3O6, CAS 612049-24-8](/s/VGYGJYAOVJTNRY-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 612049-24-8C25H25N3O6
![2-Amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O4, CAS 612049-25-9](/s/RMGKAWSSXRHBTI-UHFFFAOYSA-N.svg)
2-Amino-4-(2,3-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612049-25-9C24H22N4O4
![Methyl 2-amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C23H20ClN3O4, CAS 836641-01-1](/s/QVCCUJDUEMHWBD-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(3-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 836641-01-1C23H20ClN3O4
![2-Amino-4-(4-ethoxyphenyl)-7-methyl-5-oxo-6-(3-pyridinylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O3, CAS 612049-20-4](/s/LTEQETGBOGQZDX-UHFFFAOYSA-N.svg)
2-Amino-4-(4-ethoxyphenyl)-7-methyl-5-oxo-6-(3-pyridinylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612049-20-4C24H22N4O3
![2-Amino-7-methyl-4-(3-nitrophenyl)-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17N5O4, CAS 712296-14-5](/s/VUXQMGTXYXGBFM-UHFFFAOYSA-N.svg)
2-Amino-7-methyl-4-(3-nitrophenyl)-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 712296-14-5C22H17N5O4
![Methyl 2-amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C23H20ClN3O4, CAS 758703-60-5](/s/RMOWHZRDLOGYOI-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 758703-60-5C23H20ClN3O4
![Methyl 2-amino-4-(4-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate chemical structure, C24H23N3O5, CAS 858747-10-1](/s/LGLFXGWEPQOXGU-UHFFFAOYSA-N.svg)
Methyl 2-amino-4-(4-methoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carboxylate
CAS 858747-10-1C24H23N3O5
![2-Amino-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4-(2,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O5, CAS 612053-04-0](/s/NDYDMJJGFCWERO-UHFFFAOYSA-N.svg)
2-Amino-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4-(2,4,5-trimethoxyphenyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612053-04-0C25H24N4O5
![2-Amino-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4-(2,3,4-trimethoxyphenyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C25H24N4O5, CAS 612049-15-7](/s/DRCPQIDJSQREFG-UHFFFAOYSA-N.svg)
2-Amino-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4-(2,3,4-trimethoxyphenyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612049-15-7C25H24N4O5
![2-Amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17ClN4O2, CAS 612049-23-7](/s/XPRXAEWFKSLGPO-UHFFFAOYSA-N.svg)
2-Amino-4-(4-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612049-23-7C22H17ClN4O2
![2-Amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C24H22N4O4, CAS 443646-46-6](/s/VZOSJGBUFJYWLC-UHFFFAOYSA-N.svg)
2-Amino-4-(3,4-dimethoxyphenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 443646-46-6C24H22N4O4
![2-Amino-4-(2,3-dichlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H16Cl2N4O2, CAS 710317-09-2](/s/JQYIEPPFJGLXEU-UHFFFAOYSA-N.svg)
2-Amino-4-(2,3-dichlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 710317-09-2C22H16Cl2N4O2
![2-Amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile chemical structure, C22H17ClN4O2, CAS 612802-41-2](/s/JXPZUVSBTOZXJT-UHFFFAOYSA-N.svg)
2-Amino-4-(2-chlorophenyl)-7-methyl-5-oxo-6-(pyridin-3-ylmethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
CAS 612802-41-2C22H17ClN4O2
Related scaffolds
Same ring framework with different atoms or bond orders
