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Murcko scaffold

N-(1,3,4-Thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide scaffold

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
20
With full pages
13
Scaffold SMILES

O=C(Nc1nncs1)c1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(1,3,4-Thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide page
Murcko scaffold O=C(Nc1nncs1)c1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

N-[5-(Ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide chemical structure, C12H11N3O3S2, CAS 314023-12-6
N-[5-(Ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide
CAS 314023-12-6C12H11N3O3S2
N-[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide chemical structure, C11H6F3N3O3S, CAS 519170-65-1
N-[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide
CAS 519170-65-1C11H6F3N3O3S
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide chemical structure, C12H11N3O4S, CAS 510741-20-5
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide
CAS 510741-20-5C12H11N3O4S
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C11H9N3O3S, CAS 349441-06-1
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 349441-06-1C11H9N3O3S
N-(1,3,4-Thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C10H7N3O3S, CAS 313385-95-4
N-(1,3,4-Thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 313385-95-4C10H7N3O3S
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C12H11N3O3S, CAS 418782-73-7
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 418782-73-7C12H11N3O3S
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide chemical structure, C15H17N3O3S, CAS 510763-21-0
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide
CAS 510763-21-0C15H17N3O3S
N-[5-(2-Methoxyethylthio)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide chemical structure, C13H13N3O4S2, CAS 825598-48-9
N-[5-(2-Methoxyethylthio)-1,3,4-thiadiazol-2-yl]-1,3-benzodioxole-5-carboxamide
CAS 825598-48-9C13H13N3O4S2
N-(5-Pentan-3-yl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C15H17N3O3S, CAS 600147-22-6
N-(5-Pentan-3-yl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 600147-22-6C15H17N3O3S
Ethyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate chemical structure, C16H17N3O5S2, CAS 476465-83-5
Ethyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
CAS 476465-83-5C16H17N3O5S2
2-({5-[(1,3-Benzodioxol-5-ylcarbonyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetic acid chemical structure, C12H9N3O5S2, CAS 294853-40-0
2-({5-[(1,3-Benzodioxol-5-ylcarbonyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetic acid
CAS 294853-40-0C12H9N3O5S2
N-(5-Butan-2-ylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C14H15N3O3S2, CAS 477215-47-7
N-(5-Butan-2-ylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 477215-47-7C14H15N3O3S2
N-(5-(Methylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide chemical structure, C11H9N3O3S2, CAS 476464-04-7
N-(5-(Methylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide
CAS 476464-04-7C11H9N3O3S2
N-(5-Propylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide chemical structure, C13H13N3O3S2, CAS 381702-73-4
N-(5-Propylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-benzodioxole-5-carboxamide
CAS 381702-73-4C13H13N3O3S2
N-(5-(Butylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide chemical structure, C14H15N3O3S2, CAS 477213-97-1
N-(5-(Butylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide
CAS 477213-97-1C14H15N3O3S2
Ethyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate chemical structure, C14H13N3O5S2, CAS 476465-09-5
Ethyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
CAS 476465-09-5C14H13N3O5S2
Methyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate chemical structure, C13H11N3O5S2, CAS 476465-54-0
Methyl 2-[[5-(1,3-benzodioxole-5-carbonylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
CAS 476465-54-0C13H11N3O5S2
N-(5-(Isopropylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide chemical structure, C13H13N3O3S2, CAS 477212-30-9
N-(5-(Isopropylthio)-1,3,4-thiadiazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide
CAS 477212-30-9C13H13N3O3S2
Ethyl 2-((5-(benzo[d][1,3]dioxole-5-carboxamido)-1,3,4-thiadiazol-2-yl)thio)propanoate chemical structure, C15H15N3O5S2, CAS 476465-24-4
Ethyl 2-((5-(benzo[d][1,3]dioxole-5-carboxamido)-1,3,4-thiadiazol-2-yl)thio)propanoate
CAS 476465-24-4C15H15N3O5S2
Ethyl 2-(2-((5-(benzo[d][1,3]dioxole-5-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)acetate chemical structure, C16H16N4O6S2, CAS 1135222-03-5
Ethyl 2-(2-((5-(benzo[d][1,3]dioxole-5-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetamido)acetate
CAS 1135222-03-5C16H16N4O6S2