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Murcko scaffold

Ring system with 3 rings and 19 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
13
With full pages
5
Scaffold SMILES

O=C(Nc1nccs1)c1ccc2c(c1)C(=O)NC2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nccs1)c1ccc2c(c1)C(=O)NC2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-tert-Butyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide chemical structure, C16H15N3O3S, CAS 294891-84-2
2-tert-Butyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide
CAS 294891-84-2C16H15N3O3S
2-(2-Methylpropyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C16H15N3O3S, CAS 5963-29-1
2-(2-Methylpropyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 5963-29-1C16H15N3O3S
2-Methyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide chemical structure, C13H9N3O3S, CAS 305360-46-7
2-Methyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide
CAS 305360-46-7C13H9N3O3S
2-(2-Methoxyethyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C15H13N3O4S, CAS 831211-56-4
2-(2-Methoxyethyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 831211-56-4C15H13N3O4S
2-Ethyl-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C15H13N3O3S, CAS 832118-80-6
2-Ethyl-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxoisoindole-5-carboxamide
CAS 832118-80-6C15H13N3O3S
2-Butyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide chemical structure, C16H15N3O3S, CAS 434290-65-0
2-Butyl-1,3-dioxo-N-(1,3-thiazol-2-yl)isoindole-5-carboxamide
CAS 434290-65-0C16H15N3O3S
2-(3-Methylbutyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C17H17N3O3S, CAS 849530-40-1
2-(3-Methylbutyl)-1,3-dioxo-N-(1,3-thiazol-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 849530-40-1C17H17N3O3S
2-(2-Methoxyethyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C16H15N3O4S, CAS 890977-87-4
2-(2-Methoxyethyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 890977-87-4C16H15N3O4S
2-(2-Methylpropyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C17H17N3O3S, CAS 895926-19-9
2-(2-Methylpropyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 895926-19-9C17H17N3O3S
2-(3-Methylbutyl)-N-[(2E)-4-methyl-1,3-thiazol-2(3H)-ylidene]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C18H19N3O3S, CAS 899301-03-2
2-(3-Methylbutyl)-N-[(2E)-4-methyl-1,3-thiazol-2(3H)-ylidene]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 899301-03-2C18H19N3O3S
N-[(2E)-4,5-Dimethyl-1,3-thiazol-2(3H)-ylidene]-2-(2-methylpropyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C18H19N3O3S, CAS 1144464-78-7
N-[(2E)-4,5-Dimethyl-1,3-thiazol-2(3H)-ylidene]-2-(2-methylpropyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1144464-78-7C18H19N3O3S
2-(3-Methoxypropyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C17H17N3O4S, CAS 1144482-12-1
2-(3-Methoxypropyl)-N-(5-methyl-1,3-thiazol-2-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1144482-12-1C17H17N3O4S
Ethyl 2-({[2-(3-methylbutyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-1,3-thiazole-4-carboxylate chemical structure, C20H21N3O5S, CAS 1282097-03-3
Ethyl 2-({[2-(3-methylbutyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-1,3-thiazole-4-carboxylate
CAS 1282097-03-3C20H21N3O5S