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Murcko scaffold

Ring system with 4 rings and 19 atoms

85 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
19
Chemicals
85
With full pages
8
Scaffold SMILES

c1ccc(-c2cc(C3CC3)nc3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cc(C3CC3)nc3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 85 chemicals

7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid chemical structure, C25H24FNO4, CAS 121659-03-8
7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
CAS 121659-03-8C25H24FNO4
Pitavastatin calcium chemical structure, C50H46CaF2N2O8, CAS 147526-32-7
Pitavastatin calcium
CAS 147526-32-7C50H46CaF2N2O8
Pitavastatin chemical structure, C25H24FNO4, CAS 147511-69-1
Pitavastatin
CAS 147511-69-1C25H24FNO4
(3S,5S,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid chemical structure, C25H24FNO4
(3S,5S,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
C25H24FNO4
3,5-Dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-6-heptenoic acid chemical structure, C25H24FNO4, CAS 688735-41-3
3,5-Dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-6-heptenoic acid
CAS 688735-41-3C25H24FNO4
(E,3S,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid chemical structure, C25H24FNO4
(E,3S,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
C25H24FNO4
(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde chemical structure, C21H16FNO, CAS 148901-68-2
(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde
CAS 148901-68-2C21H16FNO
(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol chemical structure, C19H16FNO, CAS 121660-11-5
(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol
CAS 121660-11-5C19H16FNO
Pitavastatin ethyl ester chemical structure, C27H28FNO4, CAS 167073-19-0
Pitavastatin ethyl ester
CAS 167073-19-0C27H28FNO4
(E,3R,5R)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid chemical structure, C25H24FNO4, CAS 769908-13-6
(E,3R,5R)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
CAS 769908-13-6C25H24FNO4
(3R,5S,E)-Methyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate chemical structure, C26H26FNO4, CAS 849811-78-5
(3R,5S,E)-Methyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
CAS 849811-78-5C26H26FNO4
Methyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate chemical structure, C20H16FNO2, CAS 121659-86-7
Methyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate
CAS 121659-86-7C20H16FNO2
2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinecarboxaldehyde chemical structure, C19H14FNO, CAS 121660-37-5
2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinecarboxaldehyde
CAS 121660-37-5C19H14FNO
(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylonitrile chemical structure, C21H15FN2, CAS 256431-72-8
(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylonitrile
CAS 256431-72-8C21H15FN2
Ethyl (E)-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate chemical structure, C27H28FNO4, CAS 172336-32-2
Ethyl (E)-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate
CAS 172336-32-2C27H28FNO4
(5S)-3-Oxo-5-hydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-6-heptenoic acid ethyl ester chemical structure, C27H26FNO4, CAS 254452-91-0
(5S)-3-Oxo-5-hydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-6-heptenoic acid ethyl ester
CAS 254452-91-0C27H26FNO4
(3R,5S,E)-Propyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate chemical structure, C28H30FNO4, CAS 917752-49-9
(3R,5S,E)-Propyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
CAS 917752-49-9C28H30FNO4
(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt chemical structure, C50H46CaF2N2O8, CAS 254452-96-5
(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt
CAS 254452-96-5C50H46CaF2N2O8
tert-Butyl pitavastatin chemical structure, C29H32FNO4, CAS 586966-54-3
tert-Butyl pitavastatin
CAS 586966-54-3C29H32FNO4
Ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate chemical structure, C21H18FNO2, CAS 148516-11-4
Ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate
CAS 148516-11-4C21H18FNO2
Defluoro pitavastatin chemical structure, C25H25NO4, CAS 847849-67-6
Defluoro pitavastatin
CAS 847849-67-6C25H25NO4
(E)-Ethyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-5-hydroxy-3-oxohept-6-enoate chemical structure, C27H26FNO4, CAS 148901-69-3
(E)-Ethyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-5-hydroxy-3-oxohept-6-enoate
CAS 148901-69-3C27H26FNO4
(3S,5R,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid chemical structure, C25H24FNO4, CAS 254452-86-3
(3S,5R,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
CAS 254452-86-3C25H24FNO4
(R)-1-Phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate chemical structure, C33H35FN2O4, CAS 147511-70-4
(R)-1-Phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
CAS 147511-70-4C33H35FN2O4