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Murcko scaffold

1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline scaffold

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
72
With full pages
3
Scaffold SMILES

c1ccc(CCC2NCCc3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold c1ccc(CCC2NCCc3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 72 of 72 chemicals

1-(6,7-Dimethoxy-1-phenethyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone chemical structure, C21H25NO3, CAS 796867-90-8
1-(6,7-Dimethoxy-1-phenethyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone
CAS 796867-90-8C21H25NO3
1-(2-(4-HO-3,5-Dimethoxy-PH)-ET)-6-meo-2-ME-4H-isoquinolin-7-ol, hydrochloride chemical structure, C21H28ClNO5, CAS 14897-73-5
1-(2-(4-HO-3,5-Dimethoxy-PH)-ET)-6-meo-2-ME-4H-isoquinolin-7-ol, hydrochloride
CAS 14897-73-5C21H28ClNO5
(S)-1-[2-(3-Fluoro-4-methyl-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline chemical structure, C20H24FNO2, CAS 769172-84-1
(S)-1-[2-(3-Fluoro-4-methyl-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
CAS 769172-84-1C20H24FNO2
(S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride chemical structure, C20H23ClF3NO2, CAS 1296659-30-7
(S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS 1296659-30-7C20H23ClF3NO2
1-(2-p-Fluorophenylethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H20FNO, CAS 796869-30-2
1-(2-p-Fluorophenylethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS 796869-30-2C18H20FNO
1,2,3,4-Tetrahydro-6-methoxy-2-(trifluoroacetyl)-1-[2-(3,4,5-trimethoxyphenyl)ethyl]-7-isoquinolinol chemical structure, C23H26F3NO6, CAS 56771-99-4
1,2,3,4-Tetrahydro-6-methoxy-2-(trifluoroacetyl)-1-[2-(3,4,5-trimethoxyphenyl)ethyl]-7-isoquinolinol
CAS 56771-99-4C23H26F3NO6
6,7-Dimethoxy-1-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C20H22F3NO3, CAS 769173-17-3
6,7-Dimethoxy-1-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-17-3C20H22F3NO3
6,7-Dimethoxy-1-[2-(3-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C20H22F3NO2, CAS 769173-23-1
6,7-Dimethoxy-1-[2-(3-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-23-1C20H22F3NO2
6,7-Dimethoxy-1-[2-(2-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C20H22F3NO3, CAS 769173-27-5
6,7-Dimethoxy-1-[2-(2-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-27-5C20H22F3NO3
6,7-Dimethoxy-1-[2-(3-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C20H22F3NO3, CAS 769173-21-9
6,7-Dimethoxy-1-[2-(3-trifluoromethoxy-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-21-9C20H22F3NO3
6,7-Dimethoxy-1-[2-(2,4,5-trifluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H20F3NO2, CAS 769173-29-7
6,7-Dimethoxy-1-[2-(2,4,5-trifluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline
CAS 769173-29-7C19H20F3NO2
1-[2-(2,6-Difluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline chemical structure, C19H21F2NO2, CAS 769173-26-4
1-[2-(2,6-Difluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-26-4C19H21F2NO2
1-[2-(3-Chloro-2-fluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline chemical structure, C19H21ClFNO2, CAS 939791-06-7
1-[2-(3-Chloro-2-fluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
CAS 939791-06-7C19H21ClFNO2
1-[2-(4-Bromo-2-fluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline chemical structure, C19H21BrFNO2, CAS 769173-25-3
1-[2-(4-Bromo-2-fluoro-phenyl)-ethyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-25-3C19H21BrFNO2
6,7-Dimethoxy-1-[2-(3,4,5-trifluoro-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C19H20F3NO2, CAS 769173-22-0
6,7-Dimethoxy-1-[2-(3,4,5-trifluoro-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-22-0C19H20F3NO2
6,7-Dimethoxy-1-[2-(2,3,4-trifluoro-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline chemical structure, C19H20F3NO2, CAS 769173-24-2
6,7-Dimethoxy-1-[2-(2,3,4-trifluoro-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline
CAS 769173-24-2C19H20F3NO2
(S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride chemical structure, C20H23ClF3NO2
(S)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
C20H23ClF3NO2
1-(4-Hydroxyphenethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol chemical structure, C17H19NO3, CAS 131946-48-0
1-(4-Hydroxyphenethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
CAS 131946-48-0C17H19NO3
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2-phenylethyl)- chemical structure, C20H25NO2, CAS 2859-20-3
Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2-phenylethyl)-
CAS 2859-20-3C20H25NO2
Methopholine, (+)- chemical structure, C20H24ClNO2, CAS 14415-95-3
Methopholine, (+)-
CAS 14415-95-3C20H24ClNO2
1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C17H18ClN, CAS 1540199-44-7
1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline
CAS 1540199-44-7C17H18ClN
1-[2-(4-Methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H21N, CAS 1512385-17-9
1-[2-(4-Methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline
CAS 1512385-17-9C18H21N
Methopholine hydrochloride chemical structure, C20H25Cl2NO2, CAS 7558-47-6
Methopholine hydrochloride
CAS 7558-47-6C20H25Cl2NO2
Methopholine hydrobromide chemical structure, C20H25BrClNO2, CAS 100029-55-8
Methopholine hydrobromide
CAS 100029-55-8C20H25BrClNO2