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Murcko scaffold

1-Phenyltetrahydropyrimidin-2(1H)-one scaffold

39 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
39
With full pages
11
Scaffold SMILES

O=C1NCCCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyltetrahydropyrimidin-2(1H)-one page
Murcko scaffold O=C1NCCCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

1-(4-Chlorophenyl)-5,5-di(prop-2-en-1-yl)-1,4,5,6-tetrahydropyrimidin-2-ol chemical structure, C16H19ClN2O, CAS 35965-91-4
1-(4-Chlorophenyl)-5,5-di(prop-2-en-1-yl)-1,4,5,6-tetrahydropyrimidin-2-ol
CAS 35965-91-4C16H19ClN2O
2(1H)-Pyrimidinone, tetrahydro-1-(4-bromophenyl)-5,5-di-2-propenyl- chemical structure, C16H19BrN2O, CAS 35965-92-5
2(1H)-Pyrimidinone, tetrahydro-1-(4-bromophenyl)-5,5-di-2-propenyl-
CAS 35965-92-5C16H19BrN2O
1-(p-Chlorophenyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidinone chemical structure, C10H11ClN2O, CAS 6584-29-8
1-(p-Chlorophenyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
CAS 6584-29-8C10H11ClN2O
1-Phenyltetrahydropyrimidin-2(1H)-one chemical structure, C10H12N2O, CAS 56535-85-4
1-Phenyltetrahydropyrimidin-2(1H)-one
CAS 56535-85-4C10H12N2O
1-Butyl-3-(2-chlorophenyl)-4-hydroxy-4,6,6-trimethyl-1,3-diazinan-2-one chemical structure, C17H25ClN2O2, CAS 312922-87-5
1-Butyl-3-(2-chlorophenyl)-4-hydroxy-4,6,6-trimethyl-1,3-diazinan-2-one
CAS 312922-87-5C17H25ClN2O2
1-(4-Chlorophenyl)-6-hydroxy-4,4,6-trimethyl-3-(2-methylpropyl)-1,3-diazinan-2-one chemical structure, C17H25ClN2O2, CAS 368839-00-3
1-(4-Chlorophenyl)-6-hydroxy-4,4,6-trimethyl-3-(2-methylpropyl)-1,3-diazinan-2-one
CAS 368839-00-3C17H25ClN2O2
4-(2-Oxo-1,3-diazinan-1-yl)benzonitrile chemical structure, C11H11N3O, CAS 163918-99-8
4-(2-Oxo-1,3-diazinan-1-yl)benzonitrile
CAS 163918-99-8C11H11N3O
1-(4-Bromophenyl)-1,3-diazinan-2-one chemical structure, C10H11BrN2O, CAS 477739-78-9
1-(4-Bromophenyl)-1,3-diazinan-2-one
CAS 477739-78-9C10H11BrN2O
1-(4-Aminophenyl)-1,3-diazinan-2-one chemical structure, C10H13N3O, CAS 927269-10-1
1-(4-Aminophenyl)-1,3-diazinan-2-one
CAS 927269-10-1C10H13N3O
1-(4-Aminophenyl)-3-methyl-1,3-diazinan-2-one chemical structure, C11H15N3O, CAS 890825-35-1
1-(4-Aminophenyl)-3-methyl-1,3-diazinan-2-one
CAS 890825-35-1C11H15N3O
(2-Oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)acetic acid chemical structure, C12H14N2O3, CAS 944463-63-2
(2-Oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)acetic acid
CAS 944463-63-2C12H14N2O3
3-(2-Oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)propanoic acid chemical structure, C13H16N2O3, CAS 944463-71-2
3-(2-Oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)propanoic acid
CAS 944463-71-2C13H16N2O3
4-(2-Oxotetrahydropyrimidin-1(2H)-yl)benzoic acid chemical structure, C11H12N2O3, CAS 766556-61-0
4-(2-Oxotetrahydropyrimidin-1(2H)-yl)benzoic acid
CAS 766556-61-0C11H12N2O3
3-(2-Oxo-1,3-diazinan-1-yl)benzoic acid chemical structure, C11H12N2O3, CAS 1140242-88-1
3-(2-Oxo-1,3-diazinan-1-yl)benzoic acid
CAS 1140242-88-1C11H12N2O3
1-(3-Aminophenyl)-1,3-diazinan-2-one chemical structure, C10H13N3O, CAS 1250772-67-8
1-(3-Aminophenyl)-1,3-diazinan-2-one
CAS 1250772-67-8C10H13N3O
1-(4-Fluorophenyl)-6-methyltetrahydropyrimidin-2(1H)-one chemical structure, C11H13FN2O, CAS 1195782-07-0
1-(4-Fluorophenyl)-6-methyltetrahydropyrimidin-2(1H)-one
CAS 1195782-07-0C11H13FN2O
1-Methyl-3-(4-nitrophenyl)tetrahydropyrimidin-2(1H)-one chemical structure, C11H13N3O3, CAS 890825-42-0
1-Methyl-3-(4-nitrophenyl)tetrahydropyrimidin-2(1H)-one
CAS 890825-42-0C11H13N3O3
3-[4-(Aminomethyl)phenyl]-tetrahydropyrimidin-2(1H)-one chemical structure, C11H15N3O, CAS 1248060-82-3
3-[4-(Aminomethyl)phenyl]-tetrahydropyrimidin-2(1H)-one
CAS 1248060-82-3C11H15N3O
1-(5-Amino-2-fluorophenyl)-1,3-diazinan-2-one chemical structure, C10H12FN3O, CAS 1250903-02-6
1-(5-Amino-2-fluorophenyl)-1,3-diazinan-2-one
CAS 1250903-02-6C10H12FN3O
1-(3-Amino-2-methylphenyl)tetrahydropyrimidin-2(1H)-one chemical structure, C11H15N3O, CAS 1249787-17-4
1-(3-Amino-2-methylphenyl)tetrahydropyrimidin-2(1H)-one
CAS 1249787-17-4C11H15N3O
2-Methyl-4-(2-oxo-1,3-diazinan-1-yl)benzoic acid chemical structure, C12H14N2O3, CAS 1285631-37-9
2-Methyl-4-(2-oxo-1,3-diazinan-1-yl)benzoic acid
CAS 1285631-37-9C12H14N2O3
1-[4-(1-Aminoethyl)phenyl]-1,3-diazinan-2-one chemical structure, C12H17N3O, CAS 1487077-19-9
1-[4-(1-Aminoethyl)phenyl]-1,3-diazinan-2-one
CAS 1487077-19-9C12H17N3O
B-[4-(Tetrahydro-3-methyl-2-oxo-1(2H)-pyrimidinyl)phenyl]boronic acid chemical structure, C11H15BN2O3, CAS 1208313-18-1
B-[4-(Tetrahydro-3-methyl-2-oxo-1(2H)-pyrimidinyl)phenyl]boronic acid
CAS 1208313-18-1C11H15BN2O3
4-(2-Oxo-tetrahydro-pyrimidin-1-yl)-benzoic acid methyl ester chemical structure, C12H14N2O3, CAS 766556-60-9
4-(2-Oxo-tetrahydro-pyrimidin-1-yl)-benzoic acid methyl ester
CAS 766556-60-9C12H14N2O3