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Murcko scaffold

Ring system with 4 rings and 25 atoms

22 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
22
With full pages
8
Scaffold SMILES

O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nn2cncc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nn2cncc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

Vardenafil chemical structure, C23H32N6O4S, CAS 224785-90-4
Vardenafil
CAS 224785-90-4C23H32N6O4S
Vardenafil hydrochloride trihydrate chemical structure, C23H39ClN6O7S, CAS 330808-88-3
Vardenafil hydrochloride trihydrate
CAS 330808-88-3C23H39ClN6O7S
Vardenafil dihydrochloride chemical structure, C23H34Cl2N6O4S, CAS 224789-15-5
Vardenafil dihydrochloride
CAS 224789-15-5C23H34Cl2N6O4S
Vardenafil hydrochloride chemical structure, C23H33ClN6O4S, CAS 224785-91-5
Vardenafil hydrochloride
CAS 224785-91-5C23H33ClN6O4S
Vardenafil N-oxide chemical structure, C23H32N6O5S, CAS 448184-48-3
Vardenafil N-oxide
CAS 448184-48-3C23H32N6O5S
Hydroxyvardenafil chemical structure, C23H32N6O5S, CAS 224785-98-2
Hydroxyvardenafil
CAS 224785-98-2C23H32N6O5S
2-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one chemical structure, C20H26N6O4S, CAS 224785-72-2
2-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
CAS 224785-72-2C20H26N6O4S
N-Desmethylvardenafil chemical structure, C22H30N6O4S, CAS 224785-87-9
N-Desmethylvardenafil
CAS 224785-87-9C22H30N6O4S
2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one chemical structure, C23H32N6O4S, CAS 224786-49-6
2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
CAS 224786-49-6C23H32N6O4S
N-Desethylvardenafil chemical structure, C21H28N6O4S, CAS 448184-46-1
N-Desethylvardenafil
CAS 448184-46-1C21H28N6O4S
2-[2-Ethoxy-5-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one chemical structure, C24H34N6O4S, CAS 224787-06-8
2-[2-Ethoxy-5-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
CAS 224787-06-8C24H34N6O4S
Vardenafil citrate chemical structure, C29H40N6O11S, CAS 1193386-64-9
Vardenafil citrate
CAS 1193386-64-9C29H40N6O11S
Vardenafil impurity 49 chemical structure, C24H34N6O5S, CAS 1339092-18-0
Vardenafil impurity 49
CAS 1339092-18-0C24H34N6O5S
Vardenafil EP impurity A chemical structure, C21H28N6O4S, CAS 2169247-39-4
Vardenafil EP impurity A
CAS 2169247-39-4C21H28N6O4S
N-Desethyl vardenafil-d8 chemical structure, C21H28N6O4S, CAS 1184985-26-9
N-Desethyl vardenafil-d8
CAS 1184985-26-9C21H28N6O4S
Vardenafil-d5 chemical structure, C23H32N6O4S, CAS 1189685-70-8
Vardenafil-d5
CAS 1189685-70-8C23H32N6O4S
Hydroxy vardenafil-d8 chemical structure, C23H32N6O5S, CAS 1329612-34-1
Hydroxy vardenafil-d8
CAS 1329612-34-1C23H32N6O5S
(2-(5-((4-Ethylpiperazin-1-yl)sulfonyl)-2-hydroxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one) chemical structure, C21H28N6O4S, CAS 2411340-39-9
(2-(5-((4-Ethylpiperazin-1-yl)sulfonyl)-2-hydroxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one)
CAS 2411340-39-9C21H28N6O4S
Vardenafil impurity 2 chemical structure, C23H30N6O6S, CAS 1417529-69-1
Vardenafil impurity 2
CAS 1417529-69-1C23H30N6O6S
Sildenafil impurity 72 chemical structure, C24H34N6O4S, CAS 2840532-32-1
Sildenafil impurity 72
CAS 2840532-32-1C24H34N6O4S
Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-, hydrochloride, hydrate (1:2:3) chemical structure, C23H40Cl2N6O7S, CAS 946493-30-7
Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-, hydrochloride, hydrate (1:2:3)
CAS 946493-30-7C23H40Cl2N6O7S
Vardenafil impurity 65 chemical structure, C26H36N6O5S, CAS 224788-55-0
Vardenafil impurity 65
CAS 224788-55-0C26H36N6O5S