Murcko scaffold
Ring system with 4 rings and 25 atoms
11 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 11
- With full pages
- 3
Scaffold SMILES
O=S(=O)(c1cccc(-c2nc(=S)c3[nH]ncc3[nH]2)c1)N1CCNCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=S(=O)(c1cccc(-c2nc(=S)c3[nH]ncc3[nH]2)c1)N1CCNCC1](/scaffold/PEUSZVNHWIZOBD-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 11 of 11 chemicals
Hydroxythiohomosildenafil
CAS 479073-82-0C23H32N6O4S2
Propoxyphenyl thiohomosildenafil
CAS 479073-88-6C24H34N6O3S2
Desmethyl thiosildenafil
CAS 479073-86-4C21H28N6O3S2
Thiohomosildenafil
CAS 479073-80-8C23H32N6O3S2
Thiosildenafil
CAS 479073-79-5C22H30N6O3S2
Propoxyphenyl thiohydroxyhomosildenafil
CAS 479073-90-0C24H34N6O4S2
Propoxyphenyl thiosildenafil
CAS 479073-87-5C23H32N6O3S2
ThiodimethylsildenafilDISCONTINUED. Please offer T344365.
CAS 1260112-90-0C23H32N6O3S2
Desmethyl thiosildenafil-d8
CAS 1215321-44-0C21H28N6O3S2
Thioaildenafil
CAS 856190-47-1C23H32N6O3S2
Propoxyphenyl thioaildenafil
CAS 856190-49-3C24H34N6O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2cn[nH]c12](/scaffold/LRNYIYFUJPBPSA-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2cn[nH]c1211 chemicals![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nn2cncc12](/scaffold/UVPSJINCEDPYSG-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nn2cncc128 chemicals![Scaffold O=c1[nH]c(-c2cncc(S(=O)(=O)N3CCNCC3)c2)nc2c[nH]nc12](/scaffold/MPNOZHXRDHYFJX-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cncc(S(=O)(=O)N3CCNCC3)c2)nc2c[nH]nc122 chemicals![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2[nH]ccc12](/scaffold/GQDXOQWFKPDDCC-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2[nH]ccc121 chemical![Scaffold O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc1](/scaffold/IMLMBHVOASBVOW-UHFFFAOYSA-N/structure.svg)
O=c1ccc(-c2ccc3cn[nH]c3c2)cn1Cc1ccccc11 chemical![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCCCC3)c2)nn2cncc12](/scaffold/LSJIYSXGEZGAJJ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCCCC3)c2)nn2cncc121 chemical![Scaffold c1cc(-c2ccc3nc[nH]c3c2)nc(NC2CCOCC2)n1](/scaffold/QQVWMQKGEOKPQH-UHFFFAOYSA-N/structure.svg)
c1cc(-c2ccc3nc[nH]c3c2)nc(NC2CCOCC2)n11 chemical![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCCCC3)c2)nc2cn[nH]c12](/scaffold/SLISYDJJZXDCEK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCCCC3)c2)nc2cn[nH]c121 chemical
O=C(c1ccccc1)N1CCOC(c2ccc3c(c2)OCO3)O11 chemical![Scaffold O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2cc[nH]c12](/scaffold/ULPWPCBOMHIUSB-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(-c2cccc(S(=O)(=O)N3CCNCC3)c2)nc2cc[nH]c121 chemical