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Murcko scaffold

3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-one scaffold

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
20
With full pages
3
Scaffold SMILES

O=C1CC2(CCC2)Oc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-one page
Murcko scaffold O=C1CC2(CCC2)Oc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

7-Bromospiro[chromane-2,1'-cyclobutan]-4-one chemical structure, C12H11BrO2, CAS 403793-82-8
7-Bromospiro[chromane-2,1'-cyclobutan]-4-one
CAS 403793-82-8C12H11BrO2
5,7-Dihydroxyspiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H12O4, CAS 950674-57-4
5,7-Dihydroxyspiro[chroman-2,1'-cyclobutan]-4-one
CAS 950674-57-4C12H12O4
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-one chemical structure, C12H12O2, CAS 934554-40-2
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-one
CAS 934554-40-2C12H12O2
6-Bromo-7-methylspiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C13H13BrO2, CAS 934555-08-5
6-Bromo-7-methylspiro[chroman-2,1'-cyclobutan]-4-one
CAS 934555-08-5C13H13BrO2
7-Hydroxy-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one chemical structure, C12H12O3, CAS 934555-26-7
7-Hydroxy-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one
CAS 934555-26-7C12H12O3
6-Bromospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H11BrO2, CAS 934555-03-0
6-Bromospiro[chroman-2,1'-cyclobutan]-4-one
CAS 934555-03-0C12H11BrO2
6-Hydroxyspiro[[1]benzopyran-2,1'-cyclobutan]-4(3H)-one chemical structure, C12H12O3, CAS 934554-62-8
6-Hydroxyspiro[[1]benzopyran-2,1'-cyclobutan]-4(3H)-one
CAS 934554-62-8C12H12O3
6-Fluorospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H11FO2, CAS 934554-57-1
6-Fluorospiro[chroman-2,1'-cyclobutan]-4-one
CAS 934554-57-1C12H11FO2
6,8-Dichlorospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H10Cl2O2, CAS 1169847-93-1
6,8-Dichlorospiro[chroman-2,1'-cyclobutan]-4-one
CAS 1169847-93-1C12H10Cl2O2
6-Chlorospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H11ClO2, CAS 934554-96-8
6-Chlorospiro[chroman-2,1'-cyclobutan]-4-one
CAS 934554-96-8C12H11ClO2
6,8-Difluorospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H10F2O2, CAS 934554-68-4
6,8-Difluorospiro[chroman-2,1'-cyclobutan]-4-one
CAS 934554-68-4C12H10F2O2
6-Hydroxy-5,7-dimethylspiro[chromene-2,1'-cyclobutan]-4(3H)-one chemical structure, C14H16O3, CAS 891188-18-4
6-Hydroxy-5,7-dimethylspiro[chromene-2,1'-cyclobutan]-4(3H)-one
CAS 891188-18-4C14H16O3
6-Hydroxy-5,7,8-trimethyl-spiro[2H-1-benzopyran-2,1'-cyclobutan]-4(3H)-one chemical structure, C15H18O3, CAS 891188-04-8
6-Hydroxy-5,7,8-trimethyl-spiro[2H-1-benzopyran-2,1'-cyclobutan]-4(3H)-one
CAS 891188-04-8C15H18O3
7-Aminospiro[chromane-2,1'-cyclobutan]-4-one chemical structure, C12H13NO2, CAS 2167286-14-6
7-Aminospiro[chromane-2,1'-cyclobutan]-4-one
CAS 2167286-14-6C12H13NO2
5-Hydroxy-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one chemical structure, C12H12O3, CAS 2098128-55-1
5-Hydroxy-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one
CAS 2098128-55-1C12H12O3
6-Bromo-8-fluorospiro[chroman-2,1'-cyclobutan]-4-one chemical structure, C12H10BrFO2, CAS 1089706-29-5
6-Bromo-8-fluorospiro[chroman-2,1'-cyclobutan]-4-one
CAS 1089706-29-5C12H10BrFO2
5-Methoxyspiro[[1]benzopyran-2,1'-cyclobutan]-4(3H)-one chemical structure, C13H14O3, CAS 1169847-94-2
5-Methoxyspiro[[1]benzopyran-2,1'-cyclobutan]-4(3H)-one
CAS 1169847-94-2C13H14O3
8-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one chemical structure, C12H11FO2, CAS 2523299-28-5
8-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one
CAS 2523299-28-5C12H11FO2
8-Bromo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one chemical structure, C12H11BrO2, CAS 2571087-21-1
8-Bromo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-one
CAS 2571087-21-1C12H11BrO2
Methyl 4-oxo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-8-carboxylate chemical structure, C14H14O4, CAS 2517689-00-6
Methyl 4-oxo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-8-carboxylate
CAS 2517689-00-6C14H14O4