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Murcko scaffold

Ring system with 3 rings and 13 atoms

28 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
13
Chemicals
28
With full pages
4
Scaffold SMILES

c1ccc2c(c1)CCC1(CCC1)O2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc2c(c1)CCC1(CCC1)O2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

6,8-Dichlorospiro[chroman-2,1'-cyclobutan]-4-amine chemical structure, C12H13Cl2NO, CAS 934555-07-4
6,8-Dichlorospiro[chroman-2,1'-cyclobutan]-4-amine
CAS 934555-07-4C12H13Cl2NO
6-Chlorospiro[chroman-2,1'-cyclobutan]-4-amine chemical structure, C12H14ClNO, CAS 934586-12-6
6-Chlorospiro[chroman-2,1'-cyclobutan]-4-amine
CAS 934586-12-6C12H14ClNO
3,4-Dihydrospiro(1-benzopyran-2,1'-cyclobutane)-4-amine chemical structure, C12H15NO, CAS 934554-38-8
3,4-Dihydrospiro(1-benzopyran-2,1'-cyclobutane)-4-amine
CAS 934554-38-8C12H15NO
6,8-Difluorospiro[chroman-2,1'-cyclobutan]-4-amine chemical structure, C12H13F2NO, CAS 934554-70-8
6,8-Difluorospiro[chroman-2,1'-cyclobutan]-4-amine
CAS 934554-70-8C12H13F2NO
6-Fluorospiro[chroman-2,1'-cyclobutan]-4-amine chemical structure, C12H14FNO, CAS 934554-58-2
6-Fluorospiro[chroman-2,1'-cyclobutan]-4-amine
CAS 934554-58-2C12H14FNO
6-Bromospiro[chromane-2,1'-cyclobutan]-4-ol chemical structure, C12H13BrO2, CAS 1449201-20-0
6-Bromospiro[chromane-2,1'-cyclobutan]-4-ol
CAS 1449201-20-0C12H13BrO2
6-Bromospiro[chroman-2,1'-cyclobutan]-4-amine chemical structure, C12H14BrNO, CAS 934555-05-2
6-Bromospiro[chroman-2,1'-cyclobutan]-4-amine
CAS 934555-05-2C12H14BrNO
Spiro[chroman-2,1'-cyclobutan]-4-amine hcl chemical structure, C12H16ClNO, CAS 1174658-39-9
Spiro[chroman-2,1'-cyclobutan]-4-amine hcl
CAS 1174658-39-9C12H16ClNO
(4R)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine chemical structure, C12H14FNO, CAS 1145871-16-4
(4R)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine
CAS 1145871-16-4C12H14FNO
(4S)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine chemical structure, C12H14FNO, CAS 1145871-18-6
(4S)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine
CAS 1145871-18-6C12H14FNO
(4R)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine chemical structure, C12H15NO, CAS 934554-48-0
(4R)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine
CAS 934554-48-0C12H15NO
Spiro[chromane-2,1'-cyclobutan]-4-ol chemical structure, C12H14O2, CAS 1603219-02-8
Spiro[chromane-2,1'-cyclobutan]-4-ol
CAS 1603219-02-8C12H14O2
(4S)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine chemical structure, C12H15NO, CAS 934554-50-4
(4S)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine
CAS 934554-50-4C12H15NO
(S)-6-Fluorospiro[chromane-2,1'-cyclobutan]-4-ol chemical structure, C12H13FO2, CAS 1604261-88-2
(S)-6-Fluorospiro[chromane-2,1'-cyclobutan]-4-ol
CAS 1604261-88-2C12H13FO2
(4R)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-ol chemical structure, C12H13FO2, CAS 1604253-26-0
(4R)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-ol
CAS 1604253-26-0C12H13FO2
(4S)-Spiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-ol chemical structure, C12H14O2, CAS 1604428-25-2
(4S)-Spiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-ol
CAS 1604428-25-2C12H14O2
(4R)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-ol chemical structure, C12H14O2, CAS 1253965-45-5
(4R)-3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-ol
CAS 1253965-45-5C12H14O2
N-Methyl-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine chemical structure, C13H17NO, CAS 1594485-31-0
N-Methyl-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutan]-4-amine
CAS 1594485-31-0C13H17NO
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-6-amine chemical structure, C12H15NO, CAS 2044902-57-8
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-6-amine
CAS 2044902-57-8C12H15NO
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-5-ol chemical structure, C12H14O2, CAS 2098028-18-1
3,4-Dihydrospiro[1-benzopyran-2,1'-cyclobutane]-5-ol
CAS 2098028-18-1C12H14O2
6-Bromo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine hydrochloride chemical structure, C12H15BrClNO, CAS 2126178-83-2
6-Bromo-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine hydrochloride
CAS 2126178-83-2C12H15BrClNO
N-Spiro[3,4-dihydrochromene-2,1'-cyclobutane]-6-ylprop-2-enamide chemical structure, C15H17NO2, CAS 2188733-62-0
N-Spiro[3,4-dihydrochromene-2,1'-cyclobutane]-6-ylprop-2-enamide
CAS 2188733-62-0C15H17NO2
(4S)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine hydrochloride chemical structure, C12H15ClFNO, CAS 2219353-75-8
(4S)-6-Fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]-4-amine hydrochloride
CAS 2219353-75-8C12H15ClFNO
(4S)-4-Azido-6-fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane] chemical structure, C12H12FN3O, CAS 2225126-86-1
(4S)-4-Azido-6-fluoro-3,4-dihydrospiro[1-benzopyran-2,1'-cyclobutane]
CAS 2225126-86-1C12H12FN3O