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Murcko scaffold

Ring system with 7 rings and 44 atoms

120 chemicals on CompoundList share this ring system.

Rings: 7
Scaffold atoms: 44
Chemicals: 120
With full pages: 7

Scaffold SMILES

O=C(Nc1ncnc2c1ncn2C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ncnc2c1ncn2C1CCC(COC(c2ccccc2)(c2ccccc2)c2ccccc2)O1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 120 chemicals

Adenosine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy- chemical structure, C38H35N5O6, CAS 64325-78-6

Adenosine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-

CAS 64325-78-6C₃₈H₃₅N₅O₆

Adenosine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite) chemical structure, C47H52N7O7P, CAS 98796-53-3

Adenosine, N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, 3'-(2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite)

CAS 98796-53-3C₄₇H₅₂N₇O₇P

N6-Benzoyl-5'-O-(dimethoxytrityl)-3'-deoxyadenosine chemical structure, C38H35N5O6, CAS 84138-86-3

N6-Benzoyl-5'-O-(dimethoxytrityl)-3'-deoxyadenosine

CAS 84138-86-3C₃₈H₃₅N₅O₆

N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide chemical structure, C39H37N5O7, CAS 110764-72-2

N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

CAS 110764-72-2C₃₉H₃₇N₅O₇

N-Benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxyadenosine 3'-O-succinate chemical structure, C42H39N5O9, CAS 74405-42-8

N-Benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxyadenosine 3'-O-succinate

CAS 74405-42-8C₄₂H₃₉N₅O₉

DMT-2'-F-Bz-dA chemical structure, C38H34FN5O6, CAS 136834-21-4

CAS 136834-21-4C₃₈H₃₄FN₅O₆

Bz-rA Phosphoramidite chemical structure, C53H66N7O8PSi, CAS 104992-55-4

Bz-rA Phosphoramidite

CAS 104992-55-4C₅₃H₆₆N₇O₈PSi

N-Benzoyl-2'-deoxy-5'-O-(triphenylmethyl)-Adenosine chemical structure, C36H31N5O4, CAS 75759-62-5

N-Benzoyl-2'-deoxy-5'-O-(triphenylmethyl)-Adenosine

CAS 75759-62-5C₃₆H₃₁N₅O₄

DNA 5-FDMT A(Bz) amidite chemical structure, C57H55F17N7O7P, CAS 865758-44-7

DNA 5-FDMT A(Bz) amidite

CAS 865758-44-7C₅₇H₅₅F₁₇N₇O₇P

5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(methyl-N,N-diisopropyl)phosphoramidite chemical structure, C45H51N6O7P, CAS 84416-82-0

5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(methyl-N,N-diisopropyl)phosphoramidite

CAS 84416-82-0C₄₅H₅₁N₆O₇P

RefChem:828264 chemical structure, C47H51FN7O7P, CAS 136834-22-5

CAS 136834-22-5C₄₇H₅₁FN₇O₇P

2-OAlly A(Bz) amidite chemical structure, C50H56N7O8P, CAS 136834-09-8

2-OAlly A(Bz) amidite

CAS 136834-09-8C₅₀H₅₆N₇O₈P

N-(9-((2R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide chemical structure, C38H35N5O6, CAS 139260-81-4

N-(9-((2R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

CAS 139260-81-4C₃₈H₃₅N₅O₆

5'-DMTr-dA(Bz)-Methyl phosphonamidite chemical structure, C45H51N6O6P, CAS 114079-05-9

5'-DMTr-dA(Bz)-Methyl phosphonamidite

CAS 114079-05-9C₄₅H₅₁N₆O₆P

N-[9-[5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide chemical structure, C47H52N7O7P, CAS 152695-84-6

N-[9-[5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

CAS 152695-84-6C₄₇H₅₂N₇O₇P

(2R,3S,5S)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxy phenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite chemical structure, C47H52N7O7P

(2R,3S,5S)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxy phenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite

C₄₇H₅₂N₇O₇P

N-Benzoyl-5'-O-(bis(4-methoxyphenyl)(phenyl)methyl)-2'-O-(tert-butyl(dimethyl)silyl)adenosine chemical structure, C44H49N5O7Si, CAS 81265-93-2

N-Benzoyl-5'-O-(bis(4-methoxyphenyl)(phenyl)methyl)-2'-O-(tert-butyl(dimethyl)silyl)adenosine

CAS 81265-93-2C₄₄H₄₉N₅O₇Si

RefChem:828265 chemical structure, C48H54N7O8P, CAS 110782-31-5

CAS 110782-31-5C₄₈H₅₄N₇O₈P

Orb3237850 chemical structure, C53H66N7O8PSi, CAS 1803193-36-3

CAS 1803193-36-3C₅₃H₆₆N₇O₈PSi

5'-DMT-3'-TBDMS-Bz-rA chemical structure, C44H49N5O7Si, CAS 81256-88-4

5'-DMT-3'-TBDMS-Bz-rA

CAS 81256-88-4C₄₄H₄₉N₅O₇Si

N-(9-((2R,3R,4S,5R)-4-(tert-Butyldimethylsilyloxy)-3-hydroxy-5-(((4-meth oxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)ben zamide chemical structure, C43H47N5O6Si, CAS 69504-10-5

N-(9-((2R,3R,4S,5R)-4-(tert-Butyldimethylsilyloxy)-3-hydroxy-5-(((4-meth oxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)ben zamide

CAS 69504-10-5C₄₃H₄₇N₅O₆Si

5'-O-Trt-N6-Bz-dA chemical structure, C36H31N5O4

5'-O-Trt-N6-Bz-dA

C₃₆H₃₁N₅O₄

5'-DMT-Bz-rA chemical structure, C38H35N5O7, CAS 81246-82-4

CAS 81246-82-4C₃₈H₃₅N₅O₇

2-OTBS A(Bz) OMe-amidite chemical structure, C51H65N6O8PSi, CAS 118684-39-2

2-OTBS A(Bz) OMe-amidite

CAS 118684-39-2C₅₁H₆₅N₆O₈PSi