Murcko scaffold

Ring system with 4 rings and 25 atoms

256 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 256
With full pages: 9

Scaffold SMILES

O=C(CSc1nc2c(oc3ccccc32)c(=O)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nc2c(oc3ccccc32)c(=O)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 256 chemicals

2-((3-Isopropyl-4-oxo-3,4-dihydrobenzofuro[3,2-d]pyrimidin-2-yl)thio)-N-(p-tolyl)acetamide

CAS 866873-84-9C₂₂H₂₁N₃O₃S

N-(2-Fluorophenyl)-2-((3-isopropyl-4-oxo-3,4-dihydrobenzofuro[3,2-d]pyrimidin-2-yl)thio)acetamide

CAS 866873-85-0C₂₁H₁₈FN₃O₃S

N-(4-Fluorophenyl)-2-[(3-isopropyl-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)thio]acetamide

CAS 866873-86-1C₂₁H₁₈FN₃O₃S

N-(3,4-Dimethylphenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866873-87-2C₂₃H₂₃N₃O₃S

N-(3,5-Dimethylphenyl)-2-((3-isopropyl-4-oxo-3,4-dihydrobenzofuro[3,2-d]pyrimidin-2-yl)thio)acetamide

CAS 866873-88-3C₂₃H₂₃N₃O₃S

N-(2,3-Dimethylphenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866873-89-4C₂₃H₂₃N₃O₃S

N-(2-Methoxyphenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866873-90-7C₂₂H₂₁N₃O₄S

N-(2-Chlorophenyl)-2-((3-isopropyl-4-oxo-3,4-dihydrobenzofuro[3,2-d]pyrimidin-2-yl)thio)acetamide

CAS 866873-91-8C₂₁H₁₈ClN₃O₃S

N-(3-Chlorophenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866873-92-9C₂₁H₁₈ClN₃O₃S

N-(2-Ethoxyphenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866894-59-9C₂₃H₂₃N₃O₄S

N-(4-Ethoxyphenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzofuro[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

CAS 866894-60-2C₂₃H₂₃N₃O₄S

$2-{[5-(2-Methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}-N-phenylacetamide chemical structure, C21H19N3O4S, CAS 866894-61-3$

2-{[5-(2-Methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}-N-phenylacetamide

CAS 866894-61-3C₂₁H₁₉N₃O₄S

2-[[3-(2-Methoxyethyl)-4-oxo-[1]benzofuro[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(2-methylphenyl)acetamide

CAS 866894-62-4C₂₂H₂₁N₃O₄S

$N-(4-Fluorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide chemical structure, C21H18FN3O4S, CAS 866894-64-6$

N-(4-Fluorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide

CAS 866894-64-6C₂₁H₁₈FN₃O₄S

N-(2,4-Dimethylphenyl)-2-[[3-(2-methoxyethyl)-4-oxo-[1]benzofuro[3,2-d]pyrimidin-2-yl]sulfanyl]acetamide

CAS 866894-66-8C₂₃H₂₃N₃O₄S

$N-(2,3-Dimethylphenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide chemical structure, C23H23N3O4S, CAS 866894-67-9$

N-(2,3-Dimethylphenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide

CAS 866894-67-9C₂₃H₂₃N₃O₄S

2-[[3-(2-Methoxyethyl)-4-oxo-[1]benzofuro[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(3-methoxyphenyl)acetamide

CAS 866894-70-4C₂₂H₂₁N₃O₅S

2-[[3-(2-Methoxyethyl)-4-oxo-[1]benzofuro[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(4-methoxyphenyl)acetamide

CAS 866894-71-5C₂₂H₂₁N₃O₅S

$N-(2-Chlorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide chemical structure, C21H18ClN3O4S, CAS 866894-72-6$

N-(2-Chlorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide

CAS 866894-72-6C₂₁H₁₈ClN₃O₄S

$N-(3-Chlorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide chemical structure, C21H18ClN3O4S, CAS 866894-73-7$

N-(3-Chlorophenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide

CAS 866894-73-7C₂₁H₁₈ClN₃O₄S

$N-(4-Ethoxyphenyl)-2-{[5-(2-methoxyethyl)-6-oxo-8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,10,12-pentaen-4-yl]sulfanyl}acetamide chemical structure, C23H23N3O5S, CAS 866894-74-8$