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Murcko scaffold

6-Phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one scaffold

23 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
23
With full pages
5
Scaffold SMILES

O=c1[nH]c(=S)[nH]nc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-Phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one page
Murcko scaffold O=c1[nH]c(=S)[nH]nc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

2,4-Di(hydroxymethyl)-3-thioxo-6-(2-trifluoroacetylaminophenyl)-1,2,4-triazine-5(2H,4H)one chemical structure, C13H11F3N4O4S, CAS 134793-43-4
2,4-Di(hydroxymethyl)-3-thioxo-6-(2-trifluoroacetylaminophenyl)-1,2,4-triazine-5(2H,4H)one
CAS 134793-43-4C13H11F3N4O4S
6-(2-Aminophenyl)-3-sulfanylidene-3,4-dihydro-1,2,4-triazin-5(2H)-one chemical structure, C9H8N4OS, CAS 27161-64-4
6-(2-Aminophenyl)-3-sulfanylidene-3,4-dihydro-1,2,4-triazin-5(2H)-one
CAS 27161-64-4C9H8N4OS
6-(2-Amino-5-bromophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one chemical structure, C9H7BrN4OS, CAS 129951-97-9
6-(2-Amino-5-bromophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
CAS 129951-97-9C9H7BrN4OS
6-Phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one chemical structure, C9H7N3OS, CAS 447-00-7
6-Phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one
CAS 447-00-7C9H7N3OS
Acetamide, 2,2,2-trifluoro-N-(2-(2,3,4,5-tetrahydro-5-oxo-3-thioxo-1,2,4-triazin-6-yl)phenyl)- chemical structure, C11H7F3N4O2S, CAS 134793-40-1
Acetamide, 2,2,2-trifluoro-N-(2-(2,3,4,5-tetrahydro-5-oxo-3-thioxo-1,2,4-triazin-6-yl)phenyl)-
CAS 134793-40-1C11H7F3N4O2S
Acetamide, N-(2-(2,4-bis((ethenylamino)thioxomethyl)-2,3,4,5-tetrahydro-5-oxo-3-thioxo-1,2,4-triazin-6-yl)phenyl)-2,2,2-trifluoro- chemical structure, C17H13F3N6O2S3, CAS 134793-47-8
Acetamide, N-(2-(2,4-bis((ethenylamino)thioxomethyl)-2,3,4,5-tetrahydro-5-oxo-3-thioxo-1,2,4-triazin-6-yl)phenyl)-2,2,2-trifluoro-
CAS 134793-47-8C17H13F3N6O2S3
4-Amino-3-mercapto-6-phenyl-1,2,4-triazin-5(4H)-one chemical structure, C9H8N4OS, CAS 22278-82-6
4-Amino-3-mercapto-6-phenyl-1,2,4-triazin-5(4H)-one
CAS 22278-82-6C9H8N4OS
2-(5-Oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzoic acid chemical structure, C10H7N3O3S, CAS 91511-34-1
2-(5-Oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzoic acid
CAS 91511-34-1C10H7N3O3S
6-(4-Methylphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one chemical structure, C10H9N3OS, CAS 27623-05-8
6-(4-Methylphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
CAS 27623-05-8C10H9N3OS
6-(4-Methoxyphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one chemical structure, C10H9N3O2S, CAS 27623-06-9
6-(4-Methoxyphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
CAS 27623-06-9C10H9N3O2S
6-(3,4-Difluorophenyl)-3-sulfanyl-4,5-dihydro-1,2,4-triazin-5-one chemical structure, C9H5F2N3OS, CAS 874754-22-0
6-(3,4-Difluorophenyl)-3-sulfanyl-4,5-dihydro-1,2,4-triazin-5-one
CAS 874754-22-0C9H5F2N3OS
1,2,4-Triazin-5(2H)-one, 3,4-dihydro-4-nitroso-6-phenyl-3-thioxo- chemical structure, C9H6N4O2S, CAS 106119-76-0
1,2,4-Triazin-5(2H)-one, 3,4-dihydro-4-nitroso-6-phenyl-3-thioxo-
CAS 106119-76-0C9H6N4O2S
1,2,4-Triazin-5(4H)-one, 6-(4-fluorophenyl)-2,3- chemical structure, C10H8FN3OS, CAS 85683-39-2
1,2,4-Triazin-5(4H)-one, 6-(4-fluorophenyl)-2,3-
CAS 85683-39-2C10H8FN3OS
2-(5-Oxo-3-sulfanylidene-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzamide chemical structure, C10H8N4O2S, CAS 91511-36-3
2-(5-Oxo-3-sulfanylidene-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)benzamide
CAS 91511-36-3C10H8N4O2S
4-Amino-6-(3,4-dimethoxyphenyl)-3-sulfanyl-1,2,4-triazin-5(4H)-one chemical structure, C11H12N4O3S, CAS 889940-35-6
4-Amino-6-(3,4-dimethoxyphenyl)-3-sulfanyl-1,2,4-triazin-5(4H)-one
CAS 889940-35-6C11H12N4O3S
4-Amino-3-mercapto-6-(4-methylphenyl)-1,2,4-triazin-5(4H)-one chemical structure, C10H10N4OS, CAS 22445-85-8
4-Amino-3-mercapto-6-(4-methylphenyl)-1,2,4-triazin-5(4H)-one
CAS 22445-85-8C10H10N4OS
6-(2-Amino-5-chlorophenyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one chemical structure, C9H7ClN4OS, CAS 1392142-76-5
6-(2-Amino-5-chlorophenyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one
CAS 1392142-76-5C9H7ClN4OS
1,2,4-Triazin-5(4H)-one, 6-(3-ethoxyphenyl)-2,3- chemical structure, C12H13N3O2S, CAS 141627-88-5
1,2,4-Triazin-5(4H)-one, 6-(3-ethoxyphenyl)-2,3-
CAS 141627-88-5C12H13N3O2S
4-Amino-6-(3,5-dichlorophenyl)-3-sulfanylidene-2H-1,2,4-triazin-5-one chemical structure, C9H6Cl2N4OS, CAS 141605-19-8
4-Amino-6-(3,5-dichlorophenyl)-3-sulfanylidene-2H-1,2,4-triazin-5-one
CAS 141605-19-8C9H6Cl2N4OS
1,2,4-Triazin-5(4H)-one, 6-[3-chloro-4-(trifluor chemical structure, C11H7ClF3N3O2S, CAS 141627-90-9
1,2,4-Triazin-5(4H)-one, 6-[3-chloro-4-(trifluor
CAS 141627-90-9C11H7ClF3N3O2S
6-(4-Hydroxyphenyl)-3-mercapto-1,2,4-triazin-5(4H)-one chemical structure, C9H7N3O2S, CAS 874515-24-9
6-(4-Hydroxyphenyl)-3-mercapto-1,2,4-triazin-5(4H)-one
CAS 874515-24-9C9H7N3O2S
6-(2,4-Dichlorophenyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one chemical structure, C9H5Cl2N3OS, CAS 101861-64-7
6-(2,4-Dichlorophenyl)-3,4-dihydro-3-thioxo-1,2,4-triazin-5(2H)-one
CAS 101861-64-7C9H5Cl2N3OS
tert-Butyl N-[2-(5-oxo-3-sulfanyl-4,5-dihydro-1,2,4-triazin-6-yl)phenyl]carbamate chemical structure, C14H16N4O3S, CAS 2413878-91-6
tert-Butyl N-[2-(5-oxo-3-sulfanyl-4,5-dihydro-1,2,4-triazin-6-yl)phenyl]carbamate
CAS 2413878-91-6C14H16N4O3S