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Murcko scaffold

Ring system with 4 rings and 25 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
2
Scaffold SMILES

c1ccc(COc2ccc3c(Nc4ccccc4)ncnc3c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(COc2ccc3c(Nc4ccccc4)ncnc3c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

7-Benzyloxy-4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazoline chemical structure, C22H17ClFN3O2, CAS 791763-30-9
7-Benzyloxy-4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazoline
CAS 791763-30-9C22H17ClFN3O2
7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine chemical structure, C22H17BrFN3O2, CAS 768350-54-5
7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
CAS 768350-54-5C22H17BrFN3O2
7-Benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline chemical structure, C22H16BrF2N3O2, CAS 338992-37-3
7-Benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline
CAS 338992-37-3C22H16BrF2N3O2
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol chemical structure, C22H18FN3O2, CAS 193001-14-8
5-((7-(Benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol
CAS 193001-14-8C22H18FN3O2
7-Benzyloxy4-(4-bromo-2-fluoroanilino)-6-methoxyquinazoline hydrochloride chemical structure, C22H18BrClFN3O2, CAS 196603-95-9
7-Benzyloxy4-(4-bromo-2-fluoroanilino)-6-methoxyquinazoline hydrochloride
CAS 196603-95-9C22H18BrClFN3O2
7-Benzyloxy-4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazoline hydrochloride chemical structure, C22H18Cl2FN3O2, CAS 193001-61-5
7-Benzyloxy-4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazoline hydrochloride
CAS 193001-61-5C22H18Cl2FN3O2
ZM 323881 hydrochloride chemical structure, C22H19ClFN3O2, CAS 193000-39-4
ZM 323881 hydrochloride
CAS 193000-39-4C22H19ClFN3O2
5-Quinazolinol,4-[(2-chloro-5-methoxyphenyl)amino]-7-(phenylmethoxy)- chemical structure, C22H18ClN3O3, CAS 379228-29-2
5-Quinazolinol,4-[(2-chloro-5-methoxyphenyl)amino]-7-(phenylmethoxy)-
CAS 379228-29-2C22H18ClN3O3
N-(3-Bromophenyl)-6-methoxy-7-(phenylmethoxy)-4-quinazolinamine chemical structure, C22H18BrN3O2, CAS 1622326-76-4
N-(3-Bromophenyl)-6-methoxy-7-(phenylmethoxy)-4-quinazolinamine
CAS 1622326-76-4C22H18BrN3O2