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Murcko scaffold

Ring system with 4 rings and 20 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
7
With full pages
1
Scaffold SMILES

c1cc(Nc2nccn3c(-c4cn[nH]c4)cnc23)sn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cc(Nc2nccn3c(-c4cn[nH]c4)cnc23)sn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

2-(Ethyl((5-((6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol chemical structure, C20H26N8OS, CAS 1094069-99-4
2-(Ethyl((5-((6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol
CAS 1094069-99-4C20H26N8OS
3-Isothiazolemethanol, 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]- chemical structure, C20H27N7O2SSi, CAS 1094070-54-8
3-Isothiazolemethanol, 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-
CAS 1094070-54-8C20H27N7O2SSi
3-Isothiazolemethanol, 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-, 3-methanesulfonate chemical structure, C21H29N7O4S2Si, CAS 1094070-55-9
3-Isothiazolemethanol, 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-, 3-methanesulfonate
CAS 1094070-55-9C21H29N7O4S2Si
3-Methyl-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine chemical structure, C14H13N7S, CAS 936358-65-5
3-Methyl-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine
CAS 936358-65-5C14H13N7S
SCH-1473759 hydrochloride chemical structure, C20H27ClN8OS, CAS 1094067-13-6
SCH-1473759 hydrochloride
CAS 1094067-13-6C20H27ClN8OS
Methyl 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolecarboxylate chemical structure, C21H27N7O3SSi, CAS 1094070-53-7
Methyl 5-[[6-methyl-3-[1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolecarboxylate
CAS 1094070-53-7C21H27N7O3SSi
2-[Ethyl-[[5-[[6-methyl-3-[1-(2-trimethylsilylethoxymethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol chemical structure, C26H40N8O2SSi, CAS 1094071-25-6
2-[Ethyl-[[5-[[6-methyl-3-[1-(2-trimethylsilylethoxymethyl)pyrazol-4-yl]imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol
CAS 1094071-25-6C26H40N8O2SSi