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Murcko scaffold

Ring system with 5 rings and 28 atoms

61 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 28
Chemicals: 61
With full pages: 13

Scaffold SMILES

O=c1c(=Cc2ccc(-c3ccccc3)o2)sc2n1C(c1ccccc1)C=CN=2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(=Cc2ccc(-c3ccccc3)o2)sc2n1C(c1ccccc1)C=CN=2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

Ethyl 5-(2,4-dimethoxyphenyl)-7-methyl-2-[[5-(2-methyl-5-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H27N3O8S, CAS 5815-76-9

Ethyl 5-(2,4-dimethoxyphenyl)-7-methyl-2-[[5-(2-methyl-5-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5815-76-9C₃₀H₂₇N₃O₈S

Ethyl 7-methyl-2-[[5-(4-methyl-2-nitrophenyl)furan-2-yl]methylidene]-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H25N3O6S2, CAS 5820-02-0

Ethyl 7-methyl-2-[[5-(4-methyl-2-nitrophenyl)furan-2-yl]methylidene]-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5820-02-0C₂₉H₂₅N₃O₆S₂

Ethyl 2-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H24Cl2N2O6S, CAS 5820-10-0

Ethyl 2-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-5-(2,5-dimethoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5820-10-0C₂₉H₂₄Cl₂N₂O₆S

Ethyl 2-[[5-(2-chloro-4-nitrophenyl)furan-2-yl]methylidene]-5-[4-(dimethylamino)phenyl]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H25ClN4O6S, CAS 5824-92-0

Ethyl 2-[[5-(2-chloro-4-nitrophenyl)furan-2-yl]methylidene]-5-[4-(dimethylamino)phenyl]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5824-92-0C₂₉H₂₅ClN₄O₆S

Ethyl 5-[4-(dimethylamino)phenyl]-2-[[5-(3,4-dimethyl-5-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C31H30N4O6S, CAS 5826-11-9

Ethyl 5-[4-(dimethylamino)phenyl]-2-[[5-(3,4-dimethyl-5-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5826-11-9C₃₁H₃₀N₄O₆S

Ethyl 5-(3,4-dimethoxyphenyl)-2,3-dihydro-2-[[5-[2-(methoxycarbonyl)phenyl]-2-furanyl]methylene]-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C31H28N2O8S, CAS 340710-02-3

Ethyl 5-(3,4-dimethoxyphenyl)-2,3-dihydro-2-[[5-[2-(methoxycarbonyl)phenyl]-2-furanyl]methylene]-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 340710-02-3C₃₁H₂₈N₂O₈S

6-Ethyl 2-[[5-(3-carboxy-4-chlorophenyl)-2-furanyl]methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H25ClN2O7S, CAS 313701-99-4

6-Ethyl 2-[[5-(3-carboxy-4-chlorophenyl)-2-furanyl]methylene]-5-(4-ethoxyphenyl)-2,3-dihydro-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 313701-99-4C₃₀H₂₅ClN₂O₇S

Prop-2-enyl 2-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H22Cl2N2O4S2, CAS 6997-99-5

Prop-2-enyl 2-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 6997-99-5C₂₉H₂₂Cl₂N₂O₄S₂

2-[5-[(Z)-[6-Ethoxycarbonyl-5-(3-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid chemical structure, C29H24N2O7S, CAS 292870-96-3

2-[5-[(Z)-[6-Ethoxycarbonyl-5-(3-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid

CAS 292870-96-3C₂₉H₂₄N₂O₇S

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(3,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H19Cl3N2O4S, CAS 331979-70-5

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(3,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 331979-70-5C₂₇H₁₉Cl₃N₂O₄S

Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H23N3O7S, CAS 327055-63-0

Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 327055-63-0C₂₈H₂₃N₃O₇S

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(4-methoxy-2-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H22ClN3O7S, CAS 331979-74-9

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(4-methoxy-2-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 331979-74-9C₂₈H₂₂ClN₃O₇S

Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H23N3O7S, CAS 327032-65-5

Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 327032-65-5C₂₈H₂₃N₃O₇S

Ethyl (8Z)-4-methyl-8-[[5-(4-methyl-2-nitro-phenyl)-2-furyl]methylidene]-9-oxo-2-phenyl-7-thia-1,5-diazabicyclo[4.3.0]nona-3,5-diene-3-carboxylate chemical structure, C28H23N3O6S, CAS 5677-87-2

Ethyl (8Z)-4-methyl-8-[[5-(4-methyl-2-nitro-phenyl)-2-furyl]methylidene]-9-oxo-2-phenyl-7-thia-1,5-diazabicyclo[4.3.0]nona-3,5-diene-3-carboxylate

CAS 5677-87-2C₂₈H₂₃N₃O₆S

Ethyl (2Z)-2-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H25N3O8S, CAS 5832-89-3

Ethyl (2Z)-2-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5832-89-3C₂₉H₂₅N₃O₈S

Ethyl (2Z)-2-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H23ClN2O4S, CAS 5669-90-9

Ethyl (2Z)-2-[[5-(4-chlorophenyl)furan-2-yl]methylidene]-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5669-90-9C₂₈H₂₃ClN₂O₄S

2-Chloro-5-[5-[(Z)-[5-[4-(dimethylamino)phenyl]-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid chemical structure, C30H26ClN3O6S, CAS 352557-79-0

2-Chloro-5-[5-[(Z)-[5-[4-(dimethylamino)phenyl]-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid

CAS 352557-79-0C₃₀H₂₆ClN₃O₆S

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(2,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H19Cl3N2O4S, CAS 5672-43-5

Ethyl (2Z)-5-(2-chlorophenyl)-2-[[5-(2,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5672-43-5C₂₇H₁₉Cl₃N₂O₄S

Ethyl (2Z)-5-(2-chlorophenyl)-7-methyl-2-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H20ClN3O6S, CAS 370843-49-5

Ethyl (2Z)-5-(2-chlorophenyl)-7-methyl-2-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 370843-49-5C₂₇H₂₀ClN₃O₆S

Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-2-[[5-(4-methoxy-2-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H27N3O9S, CAS 5677-40-7

Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-2-[[5-(4-methoxy-2-nitrophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5677-40-7C₃₀H₂₇N₃O₉S

2-Chloro-5-(5-{(Z)-[6-(ethoxycarbonyl)-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene]methyl}furan-2-yl)benzoic acid chemical structure, C29H23ClN2O6S, CAS 292640-56-3

2-Chloro-5-(5-{(Z)-[6-(ethoxycarbonyl)-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene]methyl}furan-2-yl)benzoic acid

CAS 292640-56-3C₂₉H₂₃ClN₂O₆S

2-Chloro-5-[5-[(Z)-[5-(4-chlorophenyl)-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid chemical structure, C28H20Cl2N2O6S, CAS 5682-19-9

2-Chloro-5-[5-[(Z)-[5-(4-chlorophenyl)-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid

CAS 5682-19-9C₂₈H₂₀Cl₂N₂O₆S

Ethyl (2Z)-5-(4-chlorophenyl)-2-[[5-(2,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H19Cl3N2O4S, CAS 5682-32-6

Ethyl (2Z)-5-(4-chlorophenyl)-2-[[5-(2,4-dichlorophenyl)furan-2-yl]methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

CAS 5682-32-6C₂₇H₁₉Cl₃N₂O₄S

2-Chloro-5-[5-[(Z)-[5-(2-chlorophenyl)-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid chemical structure, C28H20Cl2N2O6S, CAS 331979-73-8

2-Chloro-5-[5-[(Z)-[5-(2-chlorophenyl)-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]furan-2-yl]benzoic acid

CAS 331979-73-8C₂₈H₂₀Cl₂N₂O₆S