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Murcko scaffold

Ring system with 4 rings and 22 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
20
With full pages
4
Scaffold SMILES

O=c1[nH]c(C=Cc2c[nH]c3ccccc23)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(C=Cc2c[nH]c3ccccc23)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

3-Methyl-2-(2-(1-methyl-1H-indol-3-yl)vinyl)quinazolin-4(3H)-one chemical structure, C20H17N3O
3-Methyl-2-(2-(1-methyl-1H-indol-3-yl)vinyl)quinazolin-4(3H)-one
C20H17N3O
(E)-3-Methyl-2-(2-(1-methyl-1H-indol-3-yl)vinyl)quinazolin-4(3H)-one chemical structure, C20H17N3O, CAS 337494-52-7
(E)-3-Methyl-2-(2-(1-methyl-1H-indol-3-yl)vinyl)quinazolin-4(3H)-one
CAS 337494-52-7C20H17N3O
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-methylquinazolin-4-one chemical structure, C21H19N3O, CAS 337494-56-1
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-methylquinazolin-4-one
CAS 337494-56-1C21H19N3O
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-methylquinazolin-4-one chemical structure, C22H21N3O2, CAS 330828-61-0
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-methylquinazolin-4-one
CAS 330828-61-0C22H21N3O2
3-Methyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C20H17N3O, CAS 337494-54-9
3-Methyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 337494-54-9C20H17N3O
2-[(E)-2-(1,2-Dimethyl-1H-indol-3-yl)ethenyl]-3-ethylquinazolin-4(3H)-one chemical structure, C22H21N3O, CAS 334505-96-3
2-[(E)-2-(1,2-Dimethyl-1H-indol-3-yl)ethenyl]-3-ethylquinazolin-4(3H)-one
CAS 334505-96-3C22H21N3O
3-Ethyl-2-[(E)-2-(5-methoxy-1,2-dimethylindol-3-yl)ethenyl]quinazolin-4-one chemical structure, C23H23N3O2, CAS 330946-54-8
3-Ethyl-2-[(E)-2-(5-methoxy-1,2-dimethylindol-3-yl)ethenyl]quinazolin-4-one
CAS 330946-54-8C23H23N3O2
6-Iodo-3-methyl-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one chemical structure, C20H16IN3O, CAS 378769-46-1
6-Iodo-3-methyl-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one
CAS 378769-46-1C20H16IN3O
3-(3-Hydroxypropyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C22H21N3O2, CAS 436853-80-4
3-(3-Hydroxypropyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 436853-80-4C22H21N3O2
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-ethyl-6-iodoquinazolin-4-one chemical structure, C22H20IN3O, CAS 381691-57-2
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-ethyl-6-iodoquinazolin-4-one
CAS 381691-57-2C22H20IN3O
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-6-iodo-3-methylquinazolin-4-one chemical structure, C21H18IN3O, CAS 381706-43-0
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-6-iodo-3-methylquinazolin-4-one
CAS 381706-43-0C21H18IN3O
3-Ethyl-6-iodo-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one chemical structure, C21H18IN3O, CAS 378216-26-3
3-Ethyl-6-iodo-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one
CAS 378216-26-3C21H18IN3O
6-Iodo-3-methyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C20H16IN3O, CAS 380580-44-9
6-Iodo-3-methyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 380580-44-9C20H16IN3O
3-Ethyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C21H19N3O, CAS 1164469-19-5
3-Ethyl-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 1164469-19-5C21H19N3O
(E)-2-(2-(1H-Indol-3-yl)vinyl)-3-methylquinazolin-4(3H)-one chemical structure, C19H15N3O, CAS 337494-49-2
(E)-2-(2-(1H-Indol-3-yl)vinyl)-3-methylquinazolin-4(3H)-one
CAS 337494-49-2C19H15N3O
2-[2-(5-Methoxy-1,2-dimethyl-1H-indol-3-yl)vinyl]-4(3H)-quinazolinone chemical structure, C21H19N3O2, CAS 5705-45-3
2-[2-(5-Methoxy-1,2-dimethyl-1H-indol-3-yl)vinyl]-4(3H)-quinazolinone
CAS 5705-45-3C21H19N3O2
(2Z)-3-Ethyl-2-(2-indol-3-ylideneethylidene)-1H-quinazolin-4-one chemical structure, C20H17N3O, CAS 5806-43-9
(2Z)-3-Ethyl-2-(2-indol-3-ylideneethylidene)-1H-quinazolin-4-one
CAS 5806-43-9C20H17N3O
(E)-2-(2-(1H-Indol-3-yl)vinyl)-3-ethyl-6-iodoquinazolin-4(3H)-one chemical structure, C20H16IN3O, CAS 381693-13-6
(E)-2-(2-(1H-Indol-3-yl)vinyl)-3-ethyl-6-iodoquinazolin-4(3H)-one
CAS 381693-13-6C20H16IN3O
(E)-2-(2-(1H-Indol-3-yl)vinyl)-6-iodo-3-methylquinazolin-4(3H)-one chemical structure, C19H14IN3O, CAS 381198-21-6
(E)-2-(2-(1H-Indol-3-yl)vinyl)-6-iodo-3-methylquinazolin-4(3H)-one
CAS 381198-21-6C19H14IN3O
(E)-2-(2-(5-Methoxy-1H-indol-3-yl)vinyl)-3-methylquinazolin-4(3H)-one chemical structure, C20H17N3O2, CAS 861634-36-8
(E)-2-(2-(5-Methoxy-1H-indol-3-yl)vinyl)-3-methylquinazolin-4(3H)-one
CAS 861634-36-8C20H17N3O2