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Murcko scaffold

Ring system with 4 rings and 23 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1ccc2ccccc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1ccc2ccccc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

3-Hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C20H15NO3, CAS 6765-52-2
3-Hydroxy-3-[2-(2-naphthyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
CAS 6765-52-2C20H15NO3
5-Bromo-3-hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one chemical structure, C20H14BrNO3, CAS 215778-58-8
5-Bromo-3-hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one
CAS 215778-58-8C20H14BrNO3
1-Ethyl-3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C22H19NO3, CAS 431053-92-8
1-Ethyl-3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one
CAS 431053-92-8C22H19NO3
Ethyl {3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C24H21NO5, CAS 370854-28-7
Ethyl {3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 370854-28-7C24H21NO5
3-Hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1-propan-2-ylindol-2-one chemical structure, C23H21NO3, CAS 689756-38-5
3-Hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1-propan-2-ylindol-2-one
CAS 689756-38-5C23H21NO3
3-Hydroxy-5-methoxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one chemical structure, C21H17NO4, CAS 832093-84-2
3-Hydroxy-5-methoxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one
CAS 832093-84-2C21H17NO4
3-Hydroxy-1-(2-methylprop-2-enyl)-3-(2-naphthalen-2-yl-2-oxoethyl)indol-2-one chemical structure, C24H21NO3, CAS 832122-56-2
3-Hydroxy-1-(2-methylprop-2-enyl)-3-(2-naphthalen-2-yl-2-oxoethyl)indol-2-one
CAS 832122-56-2C24H21NO3
Methyl {3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C23H19NO5, CAS 690226-94-9
Methyl {3-hydroxy-3-[2-(naphthalen-2-yl)-2-oxoethyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 690226-94-9C23H19NO5
5-Ethyl-3-hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one chemical structure, C22H19NO3, CAS 312498-36-5
5-Ethyl-3-hydroxy-3-(2-naphthalen-2-yl-2-oxoethyl)-1H-indol-2-one
CAS 312498-36-5C22H19NO3