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Murcko scaffold

3-((1H-Indol-3-yl)methylene)indolin-2-one scaffold

30 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
30
With full pages
2
Scaffold SMILES

O=C1Nc2ccccc2C1=Cc1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-((1H-Indol-3-yl)methylene)indolin-2-one page
Murcko scaffold O=C1Nc2ccccc2C1=Cc1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

3-[(2-Chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one chemical structure, C17H11ClN2O
3-[(2-Chloro-1H-indol-3-yl)methylidene]-1H-indol-2-one
C17H11ClN2O
3-((1H-Indol-3-yl)methylene)indolin-2-one chemical structure, C17H12N2O
3-((1H-Indol-3-yl)methylene)indolin-2-one
C17H12N2O
(Z)-3-((1H-Indol-3-yl)methylene)indolin-2-one chemical structure, C17H12N2O, CAS 22813-81-6
(Z)-3-((1H-Indol-3-yl)methylene)indolin-2-one
CAS 22813-81-6C17H12N2O
(Z)-3-((1H-Indol-3-yl)methylene)-6-chloroindolin-2-one chemical structure, C17H11ClN2O, CAS 856435-34-2
(Z)-3-((1H-Indol-3-yl)methylene)-6-chloroindolin-2-one
CAS 856435-34-2C17H11ClN2O
2-(3-((2-Oxoindolin-3-ylidene)methyl)-1H-indol-1-yl)acetic acid chemical structure, C19H14N2O3
2-(3-((2-Oxoindolin-3-ylidene)methyl)-1H-indol-1-yl)acetic acid
C19H14N2O3
tert-Butyl 3-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]indole-1-carboxylate chemical structure, C22H20N2O3, CAS 691858-16-9
tert-Butyl 3-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]indole-1-carboxylate
CAS 691858-16-9C22H20N2O3
Methyl 3-[(2-oxo-1,2-dihydro-3H-indol-3-yliden)methyl]-1H-indole-2-carboxylate chemical structure, C19H14N2O3, CAS 860611-98-9
Methyl 3-[(2-oxo-1,2-dihydro-3H-indol-3-yliden)methyl]-1H-indole-2-carboxylate
CAS 860611-98-9C19H14N2O3
[3-(2-Oxo-1,2-dihydro-indol-3-ylidenemethyl)-indol-1-yl]-acetic acid chemical structure, C19H14N2O3, CAS 676240-53-2
[3-(2-Oxo-1,2-dihydro-indol-3-ylidenemethyl)-indol-1-yl]-acetic acid
CAS 676240-53-2C19H14N2O3
2H-Indol-2-one, 1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]- chemical structure, C18H14N2O2, CAS 168464-14-0
2H-Indol-2-one, 1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-
CAS 168464-14-0C18H14N2O2
Cdk1 inhbitor chemical structure, C17H11ClN2O
Cdk1 inhbitor
C17H11ClN2O
Cdk1 inhibitor chemical structure, C17H11ClN2O, CAS 220749-41-7
Cdk1 inhibitor
CAS 220749-41-7C17H11ClN2O
Oxsi-2 chemical structure, C18H15N3O3S, CAS 1956296-96-0
Oxsi-2
CAS 1956296-96-0C18H15N3O3S
(3Z)-3-[(5-Methoxy-1H-indol-3-yl)methylidene]-1H-indol-2-one chemical structure, C18H14N2O2, CAS 168463-93-2
(3Z)-3-[(5-Methoxy-1H-indol-3-yl)methylidene]-1H-indol-2-one
CAS 168463-93-2C18H14N2O2
4-Chloro-3-[(Z)-(5-methoxy-1H-indol-3-yl)methylidene]-1H-indol-2-one chemical structure, C18H13ClN2O2, CAS 882747-37-7
4-Chloro-3-[(Z)-(5-methoxy-1H-indol-3-yl)methylidene]-1H-indol-2-one
CAS 882747-37-7C18H13ClN2O2
(Z)-N,N-Dimethyl-3-((2-oxoindolin-3-ylidene)methyl)-1H-indole-1-sulfonamide chemical structure, C19H17N3O3S, CAS 951933-39-4
(Z)-N,N-Dimethyl-3-((2-oxoindolin-3-ylidene)methyl)-1H-indole-1-sulfonamide
CAS 951933-39-4C19H17N3O3S
(Z)-3-(1H-Indol-3-ylmethylene)-5-nitro-1,3-dihydro-indol-2-one chemical structure, C17H11N3O3, CAS 1055412-54-8
(Z)-3-(1H-Indol-3-ylmethylene)-5-nitro-1,3-dihydro-indol-2-one
CAS 1055412-54-8C17H11N3O3
2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide chemical structure, C17H13N3O3S
2,3-Dihydro-3-(1H-indol-3-ylmethylene)-2-oxo-1H-indole-5-sulfonamide
C17H13N3O3S
Trigonostemon F chemical structure, C20H16N2O3, CAS 1207265-02-8
Trigonostemon F
CAS 1207265-02-8C20H16N2O3
3-[(1H-Indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide chemical structure, C17H13N3O3S, CAS 181223-16-5
3-[(1H-Indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
CAS 181223-16-5C17H13N3O3S
3-[(1-Methylindol-3-yl)methylidene]-1H-indol-2-one chemical structure, C18H14N2O, CAS 22813-84-9
3-[(1-Methylindol-3-yl)methylidene]-1H-indol-2-one
CAS 22813-84-9C18H14N2O
3-((1H-Indol-3-yl)methylene)-5-bromoindolin-2-one chemical structure, C17H11BrN2O, CAS 552332-48-6
3-((1H-Indol-3-yl)methylene)-5-bromoindolin-2-one
CAS 552332-48-6C17H11BrN2O
(3E)-3-(1H-Indol-3-ylmethylidene)-2-oxo-1H-indole-5-sulfonamide chemical structure, C17H13N3O3S
(3E)-3-(1H-Indol-3-ylmethylidene)-2-oxo-1H-indole-5-sulfonamide
C17H13N3O3S
3-[(5-Methoxy-1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-indol-2-one chemical structure, C19H16N2O2, CAS 856435-23-9
3-[(5-Methoxy-1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-indol-2-one
CAS 856435-23-9C19H16N2O2
1,3-Dihydro-3-[(1-propyl-1H-indol-3-yl)methylene]-2H-indol-2-one chemical structure, C20H18N2O, CAS 856434-72-5
1,3-Dihydro-3-[(1-propyl-1H-indol-3-yl)methylene]-2H-indol-2-one
CAS 856434-72-5C20H18N2O