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Murcko scaffold

Ring system with 4 rings and 27 atoms

26 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
26
With full pages
10
Scaffold SMILES

O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(Cc1cccnc1)C2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(Cc1cccnc1)C2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-(2,3-Dimethylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C23H19N3O3, CAS 497062-88-1
N-(2,3-Dimethylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 497062-88-1C23H19N3O3
N-(3-Iodophenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C21H14IN3O3, CAS 497062-89-2
N-(3-Iodophenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 497062-89-2C21H14IN3O3
1,3-Dioxo-N-(4-propan-2-ylphenyl)-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C24H21N3O3, CAS 497062-91-6
1,3-Dioxo-N-(4-propan-2-ylphenyl)-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 497062-91-6C24H21N3O3
1,3-Dioxo-2-(pyridin-3-ylmethyl)-N-[2-(trifluoromethyl)phenyl]isoindole-5-carboxamide chemical structure, C22H14F3N3O3, CAS 665025-28-5
1,3-Dioxo-2-(pyridin-3-ylmethyl)-N-[2-(trifluoromethyl)phenyl]isoindole-5-carboxamide
CAS 665025-28-5C22H14F3N3O3
N-[3-(tert-Butylcarbamoyl)phenyl]-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C26H24N4O4, CAS 665025-29-6
N-[3-(tert-Butylcarbamoyl)phenyl]-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 665025-29-6C26H24N4O4
2-[[1,3-Dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carbonyl]amino]-4,5-dimethoxybenzoic acid chemical structure, C24H19N3O7, CAS 665026-00-6
2-[[1,3-Dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carbonyl]amino]-4,5-dimethoxybenzoic acid
CAS 665026-00-6C24H19N3O7
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C22H17N3O4, CAS 665026-04-0
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 665026-04-0C22H17N3O4
N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C22H16ClN3O3, CAS 666711-61-1
N-(3-Chloro-2-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 666711-61-1C22H16ClN3O3
N-(4-Hydroxy-2-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C22H17N3O4, CAS 666711-62-2
N-(4-Hydroxy-2-methylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 666711-62-2C22H17N3O4
N-(4-Fluorophenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C21H14FN3O3, CAS 666711-63-3
N-(4-Fluorophenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 666711-63-3C21H14FN3O3
N-(4-Methoxyphenyl)-1,3-dioxo-2-(3-pyridinylmethyl)-5-isoindolinecarboxamide chemical structure, C22H17N3O4, CAS 832092-09-8
N-(4-Methoxyphenyl)-1,3-dioxo-2-(3-pyridinylmethyl)-5-isoindolinecarboxamide
CAS 832092-09-8C22H17N3O4
1,3-Dioxo-2-(pyridin-3-ylmethyl)-N-(2,4,6-trimethylphenyl)isoindole-5-carboxamide chemical structure, C24H21N3O3, CAS 717834-84-9
1,3-Dioxo-2-(pyridin-3-ylmethyl)-N-(2,4,6-trimethylphenyl)isoindole-5-carboxamide
CAS 717834-84-9C24H21N3O3
[4-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetic acid chemical structure, C23H17N3O5, CAS 713492-24-1
[4-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetic acid
CAS 713492-24-1C23H17N3O5
4-Chloro-2-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C22H14ClN3O5, CAS 518023-43-3
4-Chloro-2-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 518023-43-3C22H14ClN3O5
5-Bromo-2-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C22H14BrN3O5, CAS 701252-35-9
5-Bromo-2-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 701252-35-9C22H14BrN3O5
N-(4-Hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C21H15N3O4, CAS 694522-42-4
N-(4-Hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 694522-42-4C21H15N3O4
3-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C22H15N3O5, CAS 690989-72-1
3-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 690989-72-1C22H15N3O5
N-(2,4-Dimethoxyphenyl)-1,3-dioxo-2-(3-pyridinylmethyl)-5-isoindolinecarboxamide chemical structure, C23H19N3O5, CAS 712334-00-4
N-(2,4-Dimethoxyphenyl)-1,3-dioxo-2-(3-pyridinylmethyl)-5-isoindolinecarboxamide
CAS 712334-00-4C23H19N3O5
Methyl [4-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetate chemical structure, C24H19N3O5, CAS 712338-25-5
Methyl [4-({[1,3-dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)phenyl]acetate
CAS 712338-25-5C24H19N3O5
N-(3-Hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C21H15N3O4, CAS 497062-90-5
N-(3-Hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 497062-90-5C21H15N3O4
5-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzene-1,3-dicarboxylic acid chemical structure, C23H15N3O7, CAS 701247-78-1
5-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzene-1,3-dicarboxylic acid
CAS 701247-78-1C23H15N3O7
2-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-5-methylbenzoic acid chemical structure, C23H17N3O5, CAS 667434-65-3
2-({[1,3-Dioxo-2-(pyridin-3-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)-5-methylbenzoic acid
CAS 667434-65-3C23H17N3O5
N-(5-Chloro-2-hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C21H14ClN3O4, CAS 701258-44-8
N-(5-Chloro-2-hydroxyphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 701258-44-8C21H14ClN3O4
N-(3-Acetylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide chemical structure, C23H17N3O4, CAS 666711-07-5
N-(3-Acetylphenyl)-1,3-dioxo-2-(pyridin-3-ylmethyl)isoindole-5-carboxamide
CAS 666711-07-5C23H17N3O4