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Murcko scaffold

Ring system with 4 rings and 27 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
16
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(Cc1ccccc1)C2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(Cc1ccccc1)C2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Methyl 2-{[(2-benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoate chemical structure, C24H18N2O5, CAS 832106-76-0
Methyl 2-{[(2-benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoate
CAS 832106-76-0C24H18N2O5
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-4-chlorobenzoic acid chemical structure, C23H15ClN2O5, CAS 518022-73-6
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-4-chlorobenzoic acid
CAS 518022-73-6C23H15ClN2O5
5-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzene-1,3-dicarboxylic acid chemical structure, C24H16N2O7, CAS 518022-05-4
5-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzene-1,3-dicarboxylic acid
CAS 518022-05-4C24H16N2O7
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-5-hydroxybenzoic acid chemical structure, C23H16N2O6, CAS 518022-72-5
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-5-hydroxybenzoic acid
CAS 518022-72-5C23H16N2O6
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-4,5-dimethoxybenzoic acid chemical structure, C25H20N2O7, CAS 518022-76-9
2-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-4,5-dimethoxybenzoic acid
CAS 518022-76-9C25H20N2O7
Methyl (4-{[(2-benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenyl)acetate chemical structure, C25H20N2O5, CAS 712335-10-9
Methyl (4-{[(2-benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenyl)acetate
CAS 712335-10-9C25H20N2O5
2-Benzyl-N-(3-methoxyphenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C23H18N2O4, CAS 692281-19-9
2-Benzyl-N-(3-methoxyphenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 692281-19-9C23H18N2O4
(4-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenoxy)acetic acid chemical structure, C24H18N2O6, CAS 701254-50-4
(4-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenoxy)acetic acid
CAS 701254-50-4C24H18N2O6
2-Benzyl-N-(4-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C22H16N2O4, CAS 701256-40-8
2-Benzyl-N-(4-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 701256-40-8C22H16N2O4
5-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-2-hydroxybenzoic acid chemical structure, C23H16N2O6, CAS 831246-68-5
5-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-2-hydroxybenzoic acid
CAS 831246-68-5C23H16N2O6
2-Benzyl-N-(3-ethenylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C24H18N2O3, CAS 832681-50-2
2-Benzyl-N-(3-ethenylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 832681-50-2C24H18N2O3
3-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-2-methylbenzoic acid chemical structure, C24H18N2O5, CAS 701260-92-6
3-{[(2-Benzyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}-2-methylbenzoic acid
CAS 701260-92-6C24H18N2O5
5-Bromo-2-({[1,3-dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C24H17BrN2O5, CAS 667435-27-0
5-Bromo-2-({[1,3-dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 667435-27-0C24H17BrN2O5
2-({[1,3-Dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C24H18N2O5, CAS 667435-26-9
2-({[1,3-Dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 667435-26-9C24H18N2O5
4-Chloro-2-({[1,3-dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid chemical structure, C24H17ClN2O5, CAS 667435-28-1
4-Chloro-2-({[1,3-dioxo-2-(1-phenylethyl)-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
CAS 667435-28-1C24H17ClN2O5
2-Benzyl-N-(4-methoxyphenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C23H18N2O4, CAS 842116-54-5
2-Benzyl-N-(4-methoxyphenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 842116-54-5C23H18N2O4